公开(公告)号：US20060197954A1

公开(公告)日：2006-09-07

申请号：US11367302

申请日：2006-03-06

申请人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Koji Kuruma ,  Hisashi Ohtsuka ,  Tatsuo Fujikura ,  Shu Sato

发明人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Koji Kuruma ,  Hisashi Ohtsuka ,  Tatsuo Fujikura ,  Shu Sato

IPC分类号： G01N21/55

CPC分类号： G01N21/05 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058

摘要： A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio)chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.

公开(公告)号：US07625748B2

公开(公告)日：2009-12-01

申请号：US11475064

申请日：2006-06-27

申请人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Tatsuo Fujikura ,  Koji Kuruma

发明人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Tatsuo Fujikura ,  Koji Kuruma

IPC分类号： C12M3/00 ,  C12M1/34

CPC分类号： G01N21/553 ,  G01N21/05

摘要： A flow cell device is incorporated in the sensor unit for surface plasmon resonance (SPR) assay. A box shaped flow cell body has a lower surface, and is disposed in contact of the lower surface with a sensing surface for detecting reaction of sample. Two flow channels are formed in the flow cell body, for flow of the sample. Each of the flow channels include a fluid passageway, formed in the lower surface, for flow of the sample in contact with the sensing surface. Two end cavities are formed in an upper surface of the flow cell body and open therein, to extend from ends of the fluid passageway. The flow channels are arranged adjacent to one another, disposed to extend in a direction of the flow. Fluid passageways of the flow channels are overlapped partially on one another in a flow cell longitudinal direction of the flow cell body.

摘要翻译： 在用于表面等离子体共振（SPR）测定的传感器单元中并入流通池装置。 盒状流通池主体具有下表面，并且设置成与下表面接触，用于检测样品的反应。 在流动池体中形成两个流动通道用于样品的流动。 每个流动通道包括形成在下表面中的流体通道，用于与感测表面接触的样品的流动。 两个端腔形成在流动池主体的上表面并在其中打开，以从流体通道的端部延伸。 流动通道彼此相邻设置，设置成沿流动方向延伸。 流动通道的流体通道在流动池主体的流动池纵向上部分地彼此重叠。

公开(公告)号：US20070004030A1

公开(公告)日：2007-01-04

申请号：US11475064

申请日：2006-06-27

申请人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Tatsuo Fujikura ,  Koji Kuruma

发明人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Tatsuo Fujikura ,  Koji Kuruma

IPC分类号： C12M1/34

CPC分类号： G01N21/553 ,  G01N21/05

摘要： A flow cell device is incorporated in the sensor unit for surface plasmon resonance (SPR) assay. A box shaped flow cell body has a lower surface, and is disposed in contact of the lower surface with a sensing surface for detecting reaction of sample. Two flow channels are formed in the flow cell body, for flow of the sample. Each of the flow channels include a fluid passageway, formed in the lower surface, for flow of the sample in contact with the sensing surface. Two end cavities are formed in an upper surface of the flow cell body and open therein, to extend from ends of the fluid passageway. The flow channels are arranged adjacent to one another, disposed to extend in a direction of the flow. Fluid passageways of the flow channels are overlapped partially on one another in a flow cell longitudinal direction of the flow cell body.

摘要翻译： 在用于表面等离子体共振（SPR）测定的传感器单元中并入流通池装置。 盒状流通池主体具有下表面，并且设置成与下表面接触，用于检测样品的反应。 在流动池体中形成两个流动通道用于样品的流动。 每个流动通道包括形成在下表面中的流体通道，用于与感测表面接触的样品的流动。 两个端腔形成在流动池主体的上表面并在其中打开，以从流体通道的端部延伸。 流动通道彼此相邻设置，设置成沿流动方向延伸。 流动通道的流体通道在流动池主体的流动池纵向上部分地彼此重叠。

公开(公告)号：US07515270B2

公开(公告)日：2009-04-07

申请号：US11367302

申请日：2006-03-06

申请人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Koji Kuruma ,  Hisashi Ohtsuka ,  Tatsuo Fujikura ,  Shu Sato

发明人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Koji Kuruma ,  Hisashi Ohtsuka ,  Tatsuo Fujikura ,  Shu Sato

IPC分类号： G01N21/55

CPC分类号： G01N21/05 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058

摘要： A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio)chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.

摘要翻译： 表面等离子体共振（SPR）测定系统的传感器单元包括透明电介质。 薄膜具有第一表面和感测表面。 第一表面与电介质连接以构成界面。 感测表面回到第一个表面，用于检测（生物）化学反应。 流动池块具有用于将样品流动到感测表面的流动通道。 在界面处检查照明光的衰减全反射，分析配体和分析物之间的相互作用作为样品。 流动通道包括与感测表面相对设置的第一内表面，以沿着该方式延伸以使样品在两者之间流动。 第一内表面具有相对于感测表面限定的高度，并且在200-500微米的范围内。

公开(公告)号：US07715012B2

公开(公告)日：2010-05-11

申请号：US12394298

申请日：2009-02-27

申请人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Koji Kuruma ,  Hisashi Ohtsuka ,  Tatsuo Fujikura ,  Shu Sato

发明人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Koji Kuruma ,  Hisashi Ohtsuka ,  Tatsuo Fujikura ,  Shu Sato

IPC分类号： G01N21/55

CPC分类号： G01N21/05 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058

摘要： A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio) chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.

摘要翻译： 表面等离子体共振（SPR）测定系统的传感器单元包括透明电介质。 薄膜具有第一表面和感测表面。 第一表面与电介质连接以构成界面。 感测表面回到第一个表面，用于检测（生物）化学反应。 流动池块具有用于将样品流动到感测表面的流动通道。 在界面处检查照明光的衰减全反射，分析配体和分析物之间的相互作用作为样品。 流动通道包括与感测表面相对设置的第一内表面，以沿着该方式延伸以使样品在两者之间流动。 第一内表面具有相对于感测表面限定的高度，并且在200-500微米的范围内。

公开(公告)号：US20090195784A1

公开(公告)日：2009-08-06

申请号：US12394298

申请日：2009-02-27

申请人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Koji Kuruma ,  Hisashi Ohtsuka ,  Tatsuo Fujikura ,  Shu Sato

发明人： Nobuhiko Ogura ,  Hitoshi Shimizu ,  Koji Kuruma ,  Hisashi Ohtsuka ,  Tatsuo Fujikura ,  Shu Sato

IPC分类号： G01N21/55 ,  G01N21/05

CPC分类号： G01N21/05 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058

摘要： A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio) chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.

摘要翻译： 表面等离子体共振（SPR）测定系统的传感器单元包括透明电介质。 薄膜具有第一表面和感测表面。 第一表面与电介质连接以构成界面。 感测表面回到第一个表面，用于检测（生物）化学反应。 流动池块具有用于将样品流动到感测表面的流动通道。 在界面处检查照明光的衰减全反射，分析配体和分析物之间的相互作用作为样品。 流动通道包括与感测表面相对设置的第一内表面，以沿着该方式延伸以使样品在两者之间流动。 第一内表面具有相对于感测表面限定的高度，并且在200-500微米的范围内。

公开(公告)号：USD530235S1

公开(公告)日：2006-10-17

申请号：US29237425

申请日：2005-09-01

申请人： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

设计人： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

公开(公告)号：USD529829S1

公开(公告)日：2006-10-10

申请号：US29237422

申请日：2005-09-01

申请人： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

设计人： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

公开(公告)号：USD530638S1

公开(公告)日：2006-10-24

申请号：US29237426

申请日：2005-09-01

申请人： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

设计人： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

公开(公告)号：USD533473S1

公开(公告)日：2006-12-12

申请号：US29237424

申请日：2005-09-01

申请人： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki

设计人： Hitoshi Shimizu ,  Katsuaki Muraishi ,  Tatsuo Fujikura ,  Hirohiko Tsuzuki ,  Kouji Kuruma ,  Masayasu Konishi ,  Yoshiyuki Kunuki