公开(公告)号：US12247011B2

公开(公告)日：2025-03-11

申请号：US16635374

申请日：2018-07-31

Applicant: NodThera Limited

Inventor： Mark G. Bock ,  David Harrison ,  Alan Paul Watt ,  Roderick Alan Porter ,  Nicolas Felix Pierre Boutard ,  Charles-Henry Robert Yves Fabritius ,  Grzegorz Witold Topolnicki ,  Oleksandr Levenets

IPC: C07D231/12 ,  A61P37/06 ,  C07C45/68 ,  C07C201/14 ,  C07C209/36 ,  C07C263/10 ,  C07C271/28 ,  C07C271/30 ,  C07D213/55 ,  C07D231/14 ,  C07D233/60 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D241/24 ,  C07D249/08 ,  C07D307/79 ,  C07D309/12 ,  C07D409/12 ,  C07D493/04

Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.