公开(公告)号：US20240043410A1

公开(公告)日：2024-02-08

申请号：US18043883

申请日：2021-09-03

申请人： NodThera Limited

发明人： Mark G. BOCK ,  David HARRISON ,  Jane E. SCANLON

IPC分类号： C07D405/12

CPC分类号： C07D405/12 ,  C07B2200/07 ,  C07B2200/05

摘要： The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US12054461B2

公开(公告)日：2024-08-06

申请号：US17618184

申请日：2020-06-11

申请人： NodThera Limited

发明人： Mark G. Bock ,  David Harrison ,  Jane E. Scanlon

IPC分类号： C07D231/40 ,  C07D231/38

CPC分类号： C07D231/40 ,  C07D231/38

摘要： The present disclosure relates to compounds of Formula (I)




and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US12012397B2

公开(公告)日：2024-06-18

申请号：US17967599

申请日：2022-10-17

申请人： NodThera Limited

发明人： David Harrison ,  Alan Paul Watt ,  Mark G. Bock

IPC分类号： C07D403/12 ,  C07D231/38 ,  C07D237/20 ,  C07D239/42 ,  C07D249/04 ,  C07D249/14 ,  C07D261/14 ,  C07D277/52 ,  C07D285/135 ,  C07D307/66 ,  C07D401/12 ,  C07D405/12 ,  C07D471/08

CPC分类号： C07D403/12 ,  C07D231/38 ,  C07D237/20 ,  C07D239/42 ,  C07D249/04 ,  C07D249/14 ,  C07D261/14 ,  C07D277/52 ,  C07D285/135 ,  C07D307/66 ,  C07D401/12 ,  C07D405/12 ,  C07D471/08 ,  C07B2200/05

摘要： The present disclosure relates to compounds of Formula (I):




and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US20220267300A1

公开(公告)日：2022-08-25

申请号：US17618173

申请日：2020-06-11

申请人： NodThera Limited

发明人： Mark G. BOCK ,  David HARRISON ,  Jane E. SCANLON

IPC分类号： C07D401/12 ,  C07D405/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12

摘要： The present disclosure relates to compounds of Formula (I) or (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US11345669B2

公开(公告)日：2022-05-31

申请号：US16493816

申请日：2018-03-12

申请人： NodThera Limited

发明人： David Harrison ,  Alan Paul Watt ,  Nicolas Boutard ,  Charles-Henry Fabritius ,  Michal Galezowski ,  Piotr Kowalczyk ,  Oleksandr Levenets ,  Jakub Woyciechowski

IPC分类号： C07D241/12 ,  C07C275/28 ,  C07D207/12 ,  C07D213/56 ,  C07D231/12 ,  C07D231/38 ,  C07D233/64 ,  C07D237/24 ,  C07D239/26 ,  C07D261/08 ,  C07D271/06 ,  C07D333/24

摘要： The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US20220098159A1

公开(公告)日：2022-03-31

申请号：US17425461

申请日：2020-01-24

申请人： Nodthera Limited

发明人： Mark G. BOCK ,  David HARRISON

IPC分类号： C07D239/26 ,  C07D231/12 ,  C07D249/08 ,  C07D401/12

摘要： The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US20230145050A1

公开(公告)日：2023-05-11

申请号：US17967599

申请日：2022-10-17

申请人： NodThera Limited

发明人： David HARRISON ,  Alan Paul WATT ,  Mark G. BOCK

IPC分类号： C07D403/12 ,  C07D231/38 ,  C07D237/20 ,  C07D239/42 ,  C07D249/04 ,  C07D249/14 ,  C07D261/14 ,  C07D277/52 ,  C07D285/135 ,  C07D307/66 ,  C07D401/12 ,  C07D405/12 ,  C07D471/08

CPC分类号： C07D403/12 ,  C07D231/38 ,  C07D237/20 ,  C07D239/42 ,  C07D249/04 ,  C07D249/14 ,  C07D261/14 ,  C07D277/52 ,  C07D285/135 ,  C07D307/66 ,  C07D401/12 ,  C07D405/12 ,  C07D471/08 ,  C07B2200/05

摘要： The present disclosure relates to compounds of Formula (I):




and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US20230083495A1

公开(公告)日：2023-03-16

申请号：US17618188

申请日：2020-06-11

申请人： NodThera Limited

发明人： Mark G. BOCK ,  David HARRISON ,  Jane E. SCANLON

IPC分类号： C07D409/14 ,  C07D405/14 ,  C07D417/14

摘要： The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US11518757B2

公开(公告)日：2022-12-06

申请号：US16955284

申请日：2018-12-18

申请人： NodThera Limited

发明人： David Harrison ,  Alan Paul Watt ,  Mark G. Bock

IPC分类号： C07D403/12 ,  C07D231/38 ,  C07D237/20 ,  C07D239/42 ,  C07D249/04 ,  C07D249/14 ,  C07D261/14 ,  C07D277/52 ,  C07D285/135 ,  C07D307/66 ,  C07D401/12 ,  C07D405/12 ,  C07D471/08

摘要： The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

公开(公告)号：US20220227715A1

公开(公告)日：2022-07-21

申请号：US17618184

申请日：2020-06-11

申请人： NodThera Limited

发明人： Mark G. BOCK ,  David HARRISON ,  Jane E. SCANLON

IPC分类号： C07D231/40 ,  C07D231/38

摘要： The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.