公开(公告)号：US20230092143A1

公开(公告)日：2023-03-23

申请号：US17814815

申请日：2022-07-25

申请人： MOEHS IBERICA, S.L.

发明人： Abdeslam AKHATOU ,  Alicia DOBARRO RODRÍGUEZ

IPC分类号： C07D401/12 ,  C07C201/14 ,  C07D239/34 ,  C07D239/36

摘要： A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

公开(公告)号：US11168037B2

公开(公告)日：2021-11-09

申请号：US16757326

申请日：2018-10-17

申请人： UNIVERSITA' DEGLI STUDI DI CAGLIARI ,  UNIVERSITA' DEGLI STUDI DI SASSARI

发明人： Lidia Vera Giovanna De Luca ,  Silvia Gaspa ,  Antonio Valentoni ,  Gabriele Mulas ,  Andrea Porcheddu

IPC分类号： C07B39/00 ,  C07C17/06 ,  C07C253/30 ,  C07C201/14 ,  C07D213/26 ,  C07D215/12 ,  C07D217/14 ,  C07C45/41

摘要： A process that allows halogenation at the alpha-H position of alkylarenes, optionally further substituted on the aromatic or heteroaromatic ring, is described.

公开(公告)号：US20200347087A1

公开(公告)日：2020-11-05

申请号：US16724654

申请日：2019-12-23

申请人： President and Fellows of Harvard College

发明人： Andrew G. Myers ,  Ziyang Zhang

IPC分类号： C07H15/12 ,  C07H17/02 ,  C07H11/02 ,  C07H15/18 ,  C07C201/12 ,  C07C201/14 ,  C07H1/00

摘要： The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

公开(公告)号：US10195599B2

公开(公告)日：2019-02-05

申请号：US15911018

申请日：2018-03-02

申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

发明人： Ankush Venkatrao Biradar ,  Shubhangi Bhalchandra Umbarkar ,  Mohan Keraba Dongare

IPC分类号： C07D301/12 ,  C07C205/09 ,  C07C205/00 ,  B01J31/02 ,  B01J21/18 ,  B01J35/00 ,  B01J35/08 ,  B01J37/02 ,  B01J31/08 ,  B01J31/10 ,  B01J37/08 ,  C07C201/14 ,  C01B32/05

摘要： Disclosed herein is a simple process for functionalization/grafting of carbon microspheres obtained from bagasse with various active functional groups onto it and use of the same as catalyst for various organic reactions, having very high selectivity and conversion rate.

公开(公告)号：US20160167031A1

公开(公告)日：2016-06-16

申请号：US14901456

申请日：2014-06-25

申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

发明人： Ankush Venkatrao BIRADAR ,  Shubhangi Bhalchandra UMBARKAR ,  Mohan Keraba DONGARE

IPC分类号： B01J31/02 ,  C07D301/12 ,  C07C201/14 ,  B01J37/08

CPC分类号： B01J31/0237 ,  B01J21/18 ,  B01J31/0205 ,  B01J31/0225 ,  B01J31/08 ,  B01J31/10 ,  B01J35/002 ,  B01J35/08 ,  B01J37/0209 ,  B01J37/084 ,  B01J2231/342 ,  B01J2231/4205 ,  B01J2231/72 ,  C01B32/05 ,  C07C201/14 ,  C07D301/12

摘要： Disclosed herein is a simple process for functionalization/grafting of carbon microspheres obtained from bagasse with various active functional groups onto it and use of the same as catalyst for various organic reactions, having very high selectivity and conversion rate.

摘要翻译： 本文公开了一种简单的方法，用于将从具有各种活性官能团的蔗渣获得的碳微球官能化/接枝到其上，并将其用作各种有机反应的催化剂，具有非常高的选择性和转化率。

公开(公告)号：US4533776A

公开(公告)日：1985-08-06

申请号：US575649

申请日：1984-02-01

申请人： Bernd Baasner ,  Hermann Hagemann ,  Erich Klauke

发明人： Bernd Baasner ,  Hermann Hagemann ,  Erich Klauke

IPC分类号： C07C67/00 ,  C07C201/00 ,  C07C201/14 ,  C07C205/08 ,  C07C205/10 ,  C07C79/12

CPC分类号： C07C205/08 ,  C07C201/14 ,  C07C205/10 ,  C07C2101/14

摘要： In the preparation of an .alpha.-fluorinated nitroalkane of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and individually represent hydrogen, fluorine, chlorine, bromine, alkyl, halogenoalkyl or cycloalkyl, orR.sup.1 and R.sup.3 have the meaning indicated andR.sup.2 and R.sup.4 together represent an alkylene group having 3-6 carbon atoms,by conjugated nitrofluorination of the corresponding olefin of the formula ##STR2## the improvement which comprises employing about 1.1 mols of hydrogen fluoride and 1 to 2 mols of nitric acid per mol of olefin and carrying out the reaction in the presence of an agent which binds water, e.g. chlorosulphonic acid, fluorosulphonic acid, sulphur trioxide, sulphur dioxide, thionyl chloride, thionyl fluoride, sulfuryl chloride or sulfuryl fluoride. The end products, some of which are known, are useful as intermediates in synthesizing herbicides.

摘要翻译： 在制备其中R 1，R 2，R 3和R 4相同或不同并且各自表示氢，氟，氯，溴，烷基，卤代烷基或环烷基的式（Ia）的α-氟化硝基烷烃或R1和R3具有 所表示的含义，R2和R4一起表示具有3-6个碳原子的亚烷基，通过共轭硝基氟化相应的式“烯烃”烯烃，其改进包括使用约1.1摩尔氟化氢和1至2摩尔硝酸 酸/每摩尔烯烃，并在结合水的试剂存在下进行反应，例如 氯磺酸，氟磺酸，三氧化硫，二氧化硫，亚硫酰氯，亚硫酰氟，磺酰氯或硫酰氟。 其中一些已知的最终产物可用作合成除草剂的中间体。

公开(公告)号：US11891375B2

公开(公告)日：2024-02-06

申请号：US17814815

申请日：2022-07-25

申请人： MOEHS IBERICA, S.L.

发明人： Abdeslam Akhatou ,  Alicia Dobarro Rodríguez

IPC分类号： C07D401/12 ,  C07C201/14 ,  C07D239/34 ,  C07D239/36

CPC分类号： C07D401/12 ,  C07C201/14 ,  C07D239/34 ,  C07D239/36 ,  C07B2200/13

摘要： A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

公开(公告)号：US09573881B2

公开(公告)日：2017-02-21

申请号：US14652913

申请日：2013-12-20

申请人： Nippon Soda Co., Ltd.

发明人： Hiroki Inoue ,  Yuzuru Sakata ,  Shinichi Kobayashi ,  Yoshikazu Ito ,  Takashi Kitayama

IPC分类号： C07C209/74 ,  C07C17/00 ,  C07C201/14 ,  C07C209/32 ,  C07C205/12 ,  C07C211/52 ,  C07C17/12

CPC分类号： C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

摘要： The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

摘要翻译： 本发明提供由式（I）表示的卤代苯胺（其中，X 1和X 2各自独立地表示氯原子，溴原子或碘原子），卤代苯胺的制造方法等。

公开(公告)号：US5565586A

公开(公告)日：1996-10-15

申请号：US396777

申请日：1995-03-01

申请人： Kimio Hamamura ,  Chiaki Seki ,  Masayuki Konishi

发明人： Kimio Hamamura ,  Chiaki Seki ,  Masayuki Konishi

IPC分类号： A61K31/12 ,  A61K31/122 ,  A61P3/08 ,  B01J27/25 ,  C07B61/00 ,  C07C201/12 ,  C07C201/14 ,  C07C205/37 ,  C07C50/02

CPC分类号： C07C205/37

摘要： A process for the industrial preparation of the quinone derivative represented by the following general formula: ##STR1## which is an intermediate for chroman derivatives useful as a blood sugar lowering agent, and novel intermediates, encompasses the following:(1) Oxidation of the corresponding hydroquinone derivative, and(2) Hydrolysis of the corresponding acyl hydroquinone derivative with a Claisen alkali, followed by the oxidation of resulting hydrolyzate.

摘要翻译： 一种用于工业制备由以下通式表示的醌衍生物的方法：作为用作降糖剂的苯并二氢吡喃衍生物的中间体的“IMAGE”和新的中间体包括以下：（1）氧化相应的 氢醌衍生物，和（2）用Claisen碱水解相应的酰基氢醌衍生物，然后氧化得到的水解产物。

公开(公告)号：US4518812A

公开(公告)日：1985-05-21

申请号：US575636

申请日：1984-01-31

申请人： Bernd Baasner ,  Hermann Hagemann ,  Erich Klauke

发明人： Bernd Baasner ,  Hermann Hagemann ,  Erich Klauke

IPC分类号： C07C67/00 ,  C07C201/00 ,  C07C201/14 ,  C07C205/08 ,  C07C76/02 ,  C07C79/02

CPC分类号： C07C201/14 ,  C07C205/08

摘要： In the conjugated nitrofluorination of an olefin by reacting an olefin of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each independently is hydrogen, fluorine, chlorine, bromine, alkyl, halogenoalkyl or cycloalkyl, orR.sup.2 and R.sup.4 together are an alkylene radical of 3 to 6 carbon atoms,with hydrogen fluoride and nitric acid to produce an .alpha.-fluorinated nitroalkane of the formula ##STR2## the improvement which comprises effecting the reaction in a vessel protected against corrosion employing about 1 to 1.1 mols of hydrogen fluoride and about 1 to 2 mols of nitric acid per mol of olefin. The process uses much less HF than heretofore and the products are useful intermediates in making herbicides. Some of the products are new.

摘要翻译： 在烯烃的共轭硝基氟化中，通过使式（IMAGE）的烯烃反应，其中R 1，R 2，R 3和R 4各自独立地是氢，氟，氯，溴，烷基，卤代烷基或环烷基，或者R 2和R 4一起是 具有3至6个碳原子的亚烷基，与氟化氢和硝酸反应以产生下式的α-氟化的硝基烷烃：其中包括在使用约1至1.1摩尔氟化氢的保护反应的容器中进行反应 和约1至2摩尔硝酸/摩尔烯烃。 该方法使用比迄今为止少得多的HF，并且该产品是制备除草剂的有用中间体。 一些产品是新的。