公开(公告)号：US20230372574A1

公开(公告)日：2023-11-23

申请号：US18200932

申请日：2023-05-23

申请人： Northwestern University

发明人： Thomas J. Meade ,  Vinayak P. Dravid

IPC分类号： A61L15/54 ,  A61L15/18

CPC分类号： A61L15/54 ,  A61L15/18 ,  A61L2400/12 ,  A61L2420/02

摘要： Provided herein are surgical materials detectable by multiple imaging modalities, including magnetic resonance imaging (MRI) and computerized tomography (CT). In some embodiments, provided herein are surgical materials comprising bismuth nanoparticles and/or iron oxide nanoparticles.

公开(公告)号：US20220135529A1

公开(公告)日：2022-05-05

申请号：US17575235

申请日：2022-01-13

申请人： The Johns Hopkins University ,  Northwestern University

发明人： Sangeeta Ray ,  Martin G. Pomper ,  Thomas J. Meade ,  Ronnie C. Mease ,  Ying Chen ,  Xing Yang ,  Matthew Rotz

IPC分类号： C07D257/02 ,  A61K49/10 ,  A61K51/04 ,  C07D403/14 ,  A61K49/12 ,  A61K51/06 ,  A61K49/00

摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

公开(公告)号：US20210030896A1

公开(公告)日：2021-02-04

申请号：US16943820

申请日：2020-07-30

申请人： Northwestern University

发明人： Thomas J. Meade ,  Sarah G. Kamper ,  Michael A. Caldwell ,  Laura M. Lilley ,  Hao Li ,  Ana Rita Batista ,  Toloo Taghian ,  Heather L. Gray-Edwards ,  Miguel Sena-Esteves ,  Douglas R. Martin

IPC分类号： A61K49/08

摘要： Provided herein are MRI contrast agents that are conditionally activated by an enzyme from a reporter gene coupled to a gene of interest. In some embodiments, provided herein is a platform where a substrate (blocking access of water to a Gd(III) ion) is removed by an enzyme that can be changed to accommodate a number of gene therapy targets.

公开(公告)号：US10683272B2

公开(公告)日：2020-06-16

申请号：US15309009

申请日：2015-05-06

申请人： THE JOHNS HOPKINS UNIVERSITY ,  NORTHWESTERN UNIVERSITY

发明人： Sangeeta Ray ,  Martin G. Pomper ,  Thomas J. Meade ,  Ronnie C. Mease ,  Ying Chen ,  Xing Yang ,  Matthew Rotz

IPC分类号： A61K51/00 ,  A61M36/14 ,  C07D257/02 ,  A61K49/10 ,  A61K51/04 ,  C07D403/14 ,  A61K49/12 ,  A61K51/06 ,  A61K49/00

摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

公开(公告)号：US20190321492A1

公开(公告)日：2019-10-24

申请号：US16504021

申请日：2019-07-05

申请人： Northwestern University

发明人： Thomas J. Meade ,  Matthew W. Rotz ,  Robert J. Holbrook

IPC分类号： A61K49/08 ,  A61K49/18

摘要： Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.

公开(公告)号：US20170074859A1

公开(公告)日：2017-03-16

申请号：US15251681

申请日：2016-08-30

申请人： Northwestern University

发明人： Mark C. Hersam ,  Thomas J. Meade ,  Hsiang-Hua Hung

IPC分类号： G01N33/50 ,  G01N33/84 ,  A61K47/48

CPC分类号： A61K49/105 ,  A61K47/547 ,  A61K47/6923 ,  A61K49/108 ,  B82Y5/00 ,  Y10S977/906

摘要： Unmodified graphene oxide conjugated with hydrophilic small molecules for cellular delivery.

摘要翻译： 与亲水小分子结合的未改性石墨烯氧化物用于细胞递送。

公开(公告)号：US10786582B2

公开(公告)日：2020-09-29

申请号：US16504021

申请日：2019-07-05

申请人： Northwestern University

发明人： Thomas J. Meade ,  Matthew W. Rotz ,  Robert J. Holbrook

IPC分类号： A61K49/08 ,  A61K49/18

摘要： Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.

公开(公告)号：US20160375154A1

公开(公告)日：2016-12-29

申请号：US15192377

申请日：2016-06-24

申请人： Northwestern University

发明人： Thomas J. Meade ,  Matthew W. Rotz ,  Robert J. Holbrook

IPC分类号： A61K49/08 ,  A61K49/18

CPC分类号： A61K49/085 ,  A61K49/1878

摘要： Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.

摘要翻译： 本文提供了组合物Gd（III） - 二硫杂环戊烷金纳米颗粒共轭物及其使用方法。 特别地，组合物和方法可用于例如胰腺组织的体内成像（例如磁共振成像（MRI））。

公开(公告)号：US20200290982A1

公开(公告)日：2020-09-17

申请号：US16887754

申请日：2020-05-29

申请人： The Johns Hopkins University ,  Northwestern University

发明人： Sangeeta Ray ,  Martin G. Pomper ,  Thomas J. Meade ,  Ronnie C. Mease ,  Ying Chen ,  Xing Yang ,  Matthew Rotz

IPC分类号： C07D257/02 ,  A61K49/10 ,  A61K51/04 ,  C07D403/14 ,  A61K49/12 ,  A61K51/06 ,  A61K49/00

摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

公开(公告)号：US10994016B2

公开(公告)日：2021-05-04

申请号：US15251681

申请日：2016-08-30

申请人： Northwestern University

发明人： Mark C. Hersam ,  Thomas J. Meade ,  Hsiang-Hua Hung

IPC分类号： A61K47/30 ,  A61K49/08 ,  A61K49/12 ,  A61K47/54 ,  A61K47/69 ,  A61K49/10 ,  B82Y5/00

摘要： A method of bioactive molecule delivery includes providing a first aqueous medium comprising native graphene oxide and a second aqueous medium comprising a bioactive molecular component that includes Gd(III)-labeled molecules; mixing said first and second media to form a mixture thereof; co-incubating the mixture for a first period of time for coupling said molecular component on a surface of said native graphene oxide, to provide a co-incubation product; and contacting a cellular medium with said co-incubation product for a second period of time for cellular delivery of said bioactive molecular component.