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    Immunosuppressive agents and their use in therapy
    2.
    发明授权
    Immunosuppressive agents and their use in therapy 有权

    公开(公告)号：US11246907B2

    公开(公告)日：2022-02-15

    申请号：US16683188

    申请日：2019-11-13

    Applicant: Norwegian University of Science and Technology

    Inventor： Marit Otterlei

    IPC: A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K47/64 ,  A61K38/17 ,  A61K45/06

    Abstract: The present invention provides an agent, or composition containing an agent, for use in treating or preventing hypercytokinemia in a subject resulting from cytokine release from non-proliferating immune cells in blood, wherein the agent comprises:
    (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein:
    X1 is a basic amino acid;
    X2 is an aromatic amino acid;
    X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P);
    X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and
    X5 is a basic amino acid or Proline (P); or
    (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i).
    In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as kinase inhibitors.

    IMMUNOSUPPRESSIVE AGENTS AND THEIR USE IN THERAPY
    3.
    发明申请
    IMMUNOSUPPRESSIVE AGENTS AND THEIR USE IN THERAPY 审中-公开

    公开(公告)号：US20200323953A1

    公开(公告)日：2020-10-15

    申请号：US16683188

    申请日：2019-11-13

    Applicant: Norwegian University of Science and Technology

    Inventor： Marit Otterlei

    IPC: A61K38/17 ,  A61K38/08 ,  A61K47/64 ,  A61K45/06

    Abstract: The present invention provides an agent, or composition containing an agent, for use in treating or preventing hypercytokinemia in a subject resulting from cytokine release from non-proliferating immune cells in blood, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as kinase inhibitors.

    ANTIMICROBIAL AGENTS AND THEIR USE IN THERAPY
    4.
    发明申请
    ANTIMICROBIAL AGENTS AND THEIR USE IN THERAPY 审中-公开

    公开(公告)号：US20200095286A1

    公开(公告)日：2020-03-26

    申请号：US16592462

    申请日：2019-10-03

    Applicant: Norwegian University of Science and Technology

    Inventor： Marit Otterlei ,  Siri Bachke

    IPC: C07K14/00 ,  A61K38/17 ,  A01N25/08 ,  A61K31/165 ,  A61K31/35 ,  A61K31/397 ,  A61K31/43 ,  A61K31/496 ,  A61K31/7036 ,  A61K31/7048 ,  A61K38/14 ,  A61K38/16 ,  A61K41/00 ,  A61K45/06 ,  A61L2/10 ,  A61L2/16

    Abstract: The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as antibiotics.

    Anti-bacterial agents and their use in therapy
    5.
    发明授权
    Anti-bacterial agents and their use in therapy 有权

    公开(公告)号：US10570180B2

    公开(公告)日：2020-02-25

    申请号：US15570837

    申请日：2016-05-06

    Applicant: Norwegian University of Science and Technology (NTNU)

    Inventor： Marit Otterlei ,  Siri Bachke

    IPC: A01N37/18 ,  A61K38/00 ,  A61P31/04 ,  A61K38/08 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K14/00 ,  A61K38/17 ,  C07K14/47 ,  A61K47/50 ,  A61L9/20 ,  A61L27/22 ,  C12N5/078

    Abstract: The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5X6 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an aromatic amino acid or a hydrophobic amino acid that has an R group comprising at least three carbon atoms; X4 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X5 is any amino acid other than an acidic amino acid or an aromatic amino acid; and X6 is any amino acid other than an acidic amino acid or an aromatic amino acid, preferably a basic amino acid or Proline (P), wherein when X3 is not an aromatic amino acid, X5 is not lysine (K) and X6 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and composition of the invention may be used as single agents. In other aspects of the invention the agents and composition may be used in conjunction with one or more addition active agents, such as antibiotics, or in combination with UV radiation.

    Immunosuppressive agents and their use in therapy
    7.
    发明授权
    Immunosuppressive agents and their use in therapy 有权

    公开(公告)号：US10517923B2

    公开(公告)日：2019-12-31

    申请号：US15034917

    申请日：2014-11-06

    Applicant: NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)

    Inventor： Marit Otterlei

    IPC: A61K38/05 ,  A61K47/64 ,  A61K38/17 ,  A61K38/08 ,  A61K45/06

    Abstract: The present invention provides an agent, or composition containing an agent, for use in treating or preventing hypercytokinemia in a subject resulting from cytokine release from non-proliferating immune cells in blood, wherein the agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as kinase inhibitors.

    IMMUNOSUPPRESSIVE AGENTS AND THEIR USE IN THERAPY
    9.
    发明申请
    IMMUNOSUPPRESSIVE AGENTS AND THEIR USE IN THERAPY 审中-公开
    免疫抑制剂及其治疗用途

    公开(公告)号：US20160279193A1

    公开(公告)日：2016-09-29

    申请号：US15034917

    申请日：2014-11-06

    Applicant: NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)

    Inventor： Marit Otterlei

    IPC: A61K38/17 ,  A61K45/06

    Abstract: The present invention provides an agent, or composition containing an agent, for use in treating or preventing hypercytokinemia in a subject resulting from cytokine release from non-proliferating immune cells in blood, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as kinase inhibitors.

    Abstract translation: 在某些方面，本发明的试剂和组合物可以用作单一试剂。 在本发明的其它方面，本发明的药剂和组合物可以与一种或多种另外的活性剂如激酶抑制剂结合使用。

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