公开(公告)号：US10093663B2

公开(公告)日：2018-10-09

申请号：US15626981

申请日：2017-06-19

Applicant: Novartis AG

Inventor： Christopher Michael Adams ,  Michael Paul Capparelli ,  Takeru Ehara ,  Rajeshri Ganesh Karki ,  Nello Mainolfi ,  Chun Zhang

IPC: C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/404 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/55

Abstract: The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20180009795A1

公开(公告)日：2018-01-11

申请号：US15626981

申请日：2017-06-19

Applicant: Novartis AG

Inventor： Christopher Michael Adams ,  Michael Paul Capparelli ,  Takeru Ehara ,  Rajeshri Ganesh Karki ,  Nello Mainolfi ,  Chun Zhang

IPC: C07D413/06 ,  C07D413/14 ,  C07D403/06 ,  C07D401/14 ,  A61K31/55 ,  A61K31/404 ,  A61K31/5377 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/438 ,  C07D417/14 ,  C07D401/06

CPC classification number: C07D413/06 ,  A61K31/404 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/55 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US12129246B1

公开(公告)日：2024-10-29

申请号：US18589841

申请日：2024-02-28

Applicant: Novartis AG

Inventor： Daniela Angst ,  Philippe Bolduc ,  Matthew William Carson ,  Atwood Kim Cheung ,  Véronique Darsigny ,  Xiang Gao ,  Viktor Hornak ,  Keith Jendza ,  Rajesh Karki ,  Ajay Kumar Lal ,  Gang Liu ,  Justin Yik Ching Mao ,  Jeffrey M. McKenna ,  Erik Meredith ,  Muneto Mogi ,  Vivek Rauniyar ,  Liansheng Su ,  Ritesh Tichkule ,  Shuangxi Wang ,  Chun Zhang ,  Liang Zhao ,  Rui Zheng

IPC: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

Abstract: The disclosure relates to a compound of Formula (I):




or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.