公开(公告)号：US20130281473A1

公开(公告)日：2013-10-24

申请号：US13778910

申请日：2013-02-27

Applicant: Novartis AG

Inventor： Joerg BERGHAUSEN ,  Nicole BUSCHMANN ,  Pascal FURET ,  Francois GESSIER ,  Joanna HERGOVICH LISZTWAN ,  Philipp HOLZER ,  Edgar JACOBY ,  Joerg KALLEN ,  Keiichi MASUYA ,  Carole PISSOT SOLDERMANN ,  Haixia REN ,  Stefan STUTZ

IPC: C07D239/82

CPC classification number: C07D239/82 ,  C07D217/24 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

Abstract translation: 本发明涉及式（I）的取代的含氮双环杂环，其中Z是CH 2或N-R 4，X，R 1，R 2，R 4，R 6，R 7和n如说明书中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。

公开(公告)号：US20180251432A1

公开(公告)日：2018-09-06

申请号：US15974190

申请日：2018-05-08

Applicant: Novartis AG

Inventor： Daniela ANGST ,  Francois GESSIER ,  Anna VULPETTI

IPC: C07D239/47 ,  A61K31/505 ,  A61P35/02 ,  A61P29/00 ,  A61K31/506 ,  C07D401/12 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention describes new amino pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel amino pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.