公开(公告)号：US09814739B2

公开(公告)日：2017-11-14

申请号：US15378576

申请日：2016-12-14

Applicant: Novartis AG

Inventor： Sampath-Kumar Anandan ,  Virender Singh Aulakh ,  Martijn Fenaux ,  Xiaodong Lin ,  Liang Mao ,  Oliver Saunders ,  Zachary Kevin Sweeney ,  Fumiaki Yokokawa ,  Weidong Zhong

IPC: C07H19/10 ,  A61K31/7072 ,  C07H19/06 ,  A61K45/06 ,  A61K47/22

CPC classification number: A61K31/7072 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/22 ,  C07H19/06 ,  C07H19/067 ,  C07H19/10

Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.

公开(公告)号：US20170112868A1

公开(公告)日：2017-04-27

申请号：US15378576

申请日：2016-12-14

Applicant: Novartis AG

Inventor： Sampath-Kumar Anandan ,  Virender Singh Aulakh ,  Martijn Fenaux ,  Xiaodong Lin ,  Liang Mao ,  Oliver Saunders ,  Zachary Kevin Sweeney ,  Fumiaki Yokokawa ,  Weidong Zhong

IPC: A61K31/7072 ,  A61K45/06 ,  A61K47/22 ,  C07H19/06

CPC classification number: A61K31/7072 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/22 ,  C07H19/06 ,  C07H19/067 ,  C07H19/10

Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.