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公开(公告)号：US10369138B2
公开(公告)日：2019-08-06
申请号：US14861797
申请日：2015-09-22
Applicant: Novartis AG
Inventor： Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu
IPC: A61K31/427 , C07D417/14 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/496 , A61K31/4545 , C07D487/04 , A61K45/06
Abstract: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
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公开(公告)号：US10597396B2
公开(公告)日：2020-03-24
申请号：US16323668
申请日：2017-09-28
Applicant: Novartis AG
Inventor： Anthony Casarez , Markus Furegati , Guido Koch , Xiaodong Lin , Flavio Ossola , Folkert Reck , Robert Lowell Simmons , Qingming Zhu
IPC: C07D471/18 , A61K31/5025 , A61P31/04 , A61K31/551 , A61K45/06 , A61K31/407 , A61K31/427 , A61K31/431 , A61K31/439 , A61K31/496 , A61K31/546 , A61K31/535 , A61K31/4545
Abstract: This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.
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Patent Agency Ranking
公开(公告)号：US10065957B2
公开(公告)日：2018-09-04
申请号：US15718571
申请日：2017-09-28
Applicant: Novartis AG
Inventor： Anthony Casarez , Markus Furegati , Guido Koch , Xiaodong Lin , Flavio Ossola , Folkert Reck , Robert Lowell Simmons , Qingming Zhu
IPC: C07D471/18 , A61K31/439 , A61K31/5025 , A61K31/407 , A61K31/427 , A61K31/431 , A61K31/496 , A61K31/546 , A61K31/535 , A61P31/04
Abstract: This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.
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公开(公告)号：US20170112868A1
公开(公告)日：2017-04-27
申请号：US15378576
申请日：2016-12-14
Applicant: Novartis AG
Inventor： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC: A61K31/7072 , A61K45/06 , A61K47/22 , C07H19/06
CPC classification number: A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
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公开(公告)号：US09814739B2
公开(公告)日：2017-11-14
申请号：US15378576
申请日：2016-12-14
Applicant: Novartis AG
Inventor： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC: C07H19/10 , A61K31/7072 , C07H19/06 , A61K45/06 , A61K47/22
CPC classification number: A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
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公开(公告)号：US08778951B2
公开(公告)日：2014-07-15
申请号：US13773052
申请日：2013-02-21
Applicant: Novartis AG
Inventor： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC: A61K31/50 , A61K31/501 , A61K31/497 , C07D241/20
CPC classification number: A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。 还提供了治疗由CDK9介导的疾病或病症的方法。
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公开(公告)号：US20130172354A1
公开(公告)日：2013-07-04
申请号：US13773052
申请日：2013-02-21
Applicant: Novartis AG
Inventor： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC: C07D401/04 , C07D409/14 , C07D413/14 , C07D401/14 , C07D405/14
CPC classification number: A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。 还提供了治疗由CDK9介导的疾病或病症的方法。
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