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公开(公告)号:US09988416B2
公开(公告)日:2018-06-05
申请号:US15465485
申请日:2017-03-21
Applicant: NOVARTIS AG
Inventor: Martijn Fenaux , Oliver Saunders , Fumiaki Yokokawa , Weidong Zhong
IPC: C07H19/14 , A61K31/7064 , C07H19/04 , C07D487/04
CPC classification number: C07H19/14 , A61K31/7064 , C07D487/04 , C07H19/04
Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions for treatment of viral infections, especially HRV.
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公开(公告)号:US09814739B2
公开(公告)日:2017-11-14
申请号:US15378576
申请日:2016-12-14
Applicant: Novartis AG
Inventor: Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC: C07H19/10 , A61K31/7072 , C07H19/06 , A61K45/06 , A61K47/22
CPC classification number: A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
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公开(公告)号:US10428105B2
公开(公告)日:2019-10-01
申请号:US15974469
申请日:2018-05-08
Applicant: NOVARTIS AG
Inventor: Martijn Fenaux , Oliver Saunders , Fumiaki Yokokawa , Weidong Zhong
IPC: C07H19/14 , A61K31/7064 , C07D487/04 , C07H19/04
Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions for treatment of viral infections, especially HRV.
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公开(公告)号:US20170112868A1
公开(公告)日:2017-04-27
申请号:US15378576
申请日:2016-12-14
Applicant: Novartis AG
Inventor: Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC: A61K31/7072 , A61K45/06 , A61K47/22 , C07H19/06
CPC classification number: A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
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