公开(公告)号：US20230302155A1

公开(公告)日：2023-09-28

申请号：US18022058

申请日：2021-08-20

Applicant: Novartis AG

Inventor： Sandeep Tharian Koshy ,  Glenn Dranoff ,  Maria Anna Sofia Broggi ,  Chris Bridgeman ,  Stephen Michael Canham ,  Yoel Melles ,  Regis Cebe ,  Brian Walter Granda ,  Louise Mary Treanor ,  Shyamali Jayashankar ,  Jennifer Yang ,  Amy Rayo ,  Andrew Patrick Price ,  Darko Skegro ,  Justine Guyot ,  Tushar Dattu Apsunde ,  Cameron Chuck-munn Lee ,  Michael Bardroff ,  Sandra Miller

IPC: A61K47/69 ,  A61K9/06 ,  A61K38/18 ,  C12N15/86 ,  A61K38/20 ,  A61K38/17 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61K31/4745

CPC classification number: A61K47/6927 ,  A61K9/06 ,  A61K38/1858 ,  C12N15/86 ,  A61K38/2086 ,  A61K38/2046 ,  A61K47/6901 ,  A61K38/1774 ,  C07K14/70517 ,  C07K14/70578 ,  A61K38/177 ,  C07K14/70521 ,  C07K14/7051 ,  C07K16/2806 ,  C07K16/2818 ,  C07K16/2809 ,  A61K39/3955 ,  A61K39/4631 ,  A61K31/4745 ,  C12N2740/15043 ,  C12N2740/15071 ,  A61K2039/505 ,  C07K2319/33 ,  C07K2319/03 ,  A61K2239/21 ,  C07K2319/02 ,  A61K2239/22 ,  C07K2317/31 ,  A61K2239/29 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/522 ,  A61K2039/545 ,  A61K2239/38 ,  A61K2239/13 ,  C07K2317/75

Abstract: Aspects of this disclosure relate generally to the use of biomaterials for the in vivo generation of CAR expressing cells. In some embodiments, the biomaterials comprise one or more of a cell recruitment composition, a viral vector, and/or a cell activation agent.

公开(公告)号：US20220152150A1

公开(公告)日：2022-05-19

申请号：US17433812

申请日：2020-02-24

Applicant: Novartis AG

Inventor： Sandeep Tharian Koshy ,  Stephen M. Canham

IPC: A61K38/17 ,  A61K47/69 ,  A61K47/59 ,  A61K48/00 ,  A61K47/64 ,  A61K31/4745 ,  C12N5/0783 ,  C12N15/86

Abstract: The present invention relates generally to the use of compositions including mesoporous silica particles that may be surface modified, for the delivery of viral vectors. In some embodiments, the viral vectors are used to transduce T cells to express a chimeric antigen receptor (CAR), to treat a subject having a disease, e.g., a disease associated with expression of a tumor antigen.

公开(公告)号：US20250000973A1

公开(公告)日：2025-01-02

申请号：US18684417

申请日：2022-08-19

Applicant: Novartis AG

Inventor： Michael Bardroff ,  Regis Cebe ,  Brian Walter Granda ,  Shyamali Jayashankar ,  Sandeep Tharian Koshy ,  Sandra Miller ,  Andrew Patrick Price ,  Amy Rayo ,  Darko Skegro ,  Louise Mary Treanor ,  Jennifer Yang

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783

Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.