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    Electroporation-induced electrosensitization
    1.
    发明授权
    Electroporation-induced electrosensitization 有权

    公开(公告)号：US10982206B2

    公开(公告)日：2021-04-20

    申请号：US15972856

    申请日：2018-05-07

    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

    Inventor： Olga Pakhomova ,  Andrei G. Pakhomov

    IPC: C12N13/00 ,  A61N1/32

    Abstract: Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.

    ELECTROPORATION-INDUCED ELECTROSENSITIZATION
    2.
    发明申请
    ELECTROPORATION-INDUCED ELECTROSENSITIZATION 有权

    公开(公告)号：US20210214712A1

    公开(公告)日：2021-07-15

    申请号：US17215773

    申请日：2021-03-29

    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

    Inventor： Olga Pakhomova ,  Andrei G. Pakhomov

    IPC: C12N13/00 ,  A61N1/32

    Abstract: Systems and methods of enhancing membrane permeabilization in a cell are provided. An example method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the systems and methods, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.

    Electroporation-induced electrosensitization
    7.
    发明授权
    Electroporation-induced electrosensitization 有权

    公开(公告)号：US11820976B2

    公开(公告)日：2023-11-21

    申请号：US17215773

    申请日：2021-03-29

    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

    Inventor： Olga Pakhomova ,  Andrei G. Pakhomov

    IPC: A61N1/32 ,  C12N13/00

    CPC classification number: C12N13/00 ,  A61N1/327

    Abstract: Systems and methods of enhancing membrane permeabilization in a cell are provided. An example method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the systems and methods, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.

    Low-energy defibrillation with nanosecond pulsed electric fields
    8.
    发明授权
    Low-energy defibrillation with nanosecond pulsed electric fields 有权

    公开(公告)号：US10603503B2

    公开(公告)日：2020-03-31

    申请号：US15554808

    申请日：2016-03-02

    Applicant: Old Dominion University Research Foundation

    Inventor： Andrei G. Pakhomov ,  Christian W. Zemlin

    IPC: A61N1/39 ,  A61N1/32

    Abstract: Methods for terminating fibrillation in a fibrillating heart employing nanosecond pulsed electric fields (nsPEFs) are disclosed. nsPEF defibrillation demonstrates its effectiveness as a new defibrillation modality, achieving reliable defibrillation with energies that are an order of magnitude lower than those needed for conventional defibrillation (millisecond shocks with mono- and bi-phasic waveforms). Tests did not reveal any negative effect of nsPEF defibrillation on cardiac tissue, in particular, cardiac tissue treated with nsPEFs does not exhibit a baseline shift in the optical transmembrane potential signal (distinctive feature that indicates electroporation), or changes in action potential duration or shape. The mechanism of nsPEF defibrillation is likely different from conventional defibrillation since it does not rely on membrane charging but on the basis of displacement currents that flow within nanoseconds after the shock is applied. nsPEFs provide the technology for the next generation of defibrillators that help emergency medical services to treat patients effectively.

    METHODS AND DEVICES FOR USING SUB-MICROSECOND ELECTRIC PULSES TO TRIGGER APOPTOSIS
    9.
    发明申请
    METHODS AND DEVICES FOR USING SUB-MICROSECOND ELECTRIC PULSES TO TRIGGER APOPTOSIS 审中-公开

    公开(公告)号：US20180110557A1

    公开(公告)日：2018-04-26

    申请号：US15789727

    申请日：2017-10-20

    Applicant: Old Dominion University Research Foundation

    Inventor： Claudia Muratori ,  Andrei G. Pakhomov ,  Olga N. Pakhomova

    IPC: A61B18/12

    Abstract: The methods disclosed herein are directed towards improving ablation efficiency associated with applying nanosecond electric pulses (nsEP) to tissue. In particular, applying nsEP to tissue can open pores in the cellular membranes of the tissue. These pores can be kept open longer by cooling the tissue. The combined application of nsEP and the cooling of tissue may have synergistic effects on triggering apoptosis of cells in the tissue. This allows for numerous practical benefits associated with nsEP-based tissue ablation to be realized. For instance, nsEP of lower pulse strength or lower numbers of pulses to be used, which can be provided by smaller pulse generators operating on less power.

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