公开(公告)号：US20240382467A1

公开(公告)日：2024-11-21

申请号：US18286976

申请日：2022-04-14

Applicant: University of Virginia Patent Foundation ,  Old Dominion University ,  OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： John S. Lazo ,  Elizabeth R. Sharlow ,  John D. Catravas ,  Ruben ML Colunga Biancatelli ,  Pavel A. Solopov

IPC: A61K31/4365 ,  A61P31/14 ,  A61P39/00

Abstract: Provided are methods for treating and/or preventing diseases, disorders, and/or conditions associated with viral infections in subjects, which in some embodiments can include administering to the subject an effective amount of a PTP4A3 inhibitor. In some embodiments, the disease, disorder, and/or condition is characterized by lung damage, ALI, ARDS, or any combination thereof. Also provided are methods for reducing or inhibiting virus-induced alveolar inflammation and/or damage, methods for reducing or inhibiting induction of inflammatory cytokines and/or chemokines in subjects, methods for reducing or inhibiting pulmonary diseases, disorders, and/or conditions associated with viral infections, or pulmonary damage resulting therefrom, methods for preventing and/or treating chemical damage to lungs, uses of PTP4A3 inhibitors in the presently disclosed methods.

公开(公告)号：US20230191114A1

公开(公告)日：2023-06-22

申请号：US17996104

申请日：2021-02-12

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Claudia MURATORI ,  Erin B. PURCELL ,  Asia POUDEL ,  Adenrele M. OLUDIRAN

IPC: A61N1/04 ,  A61N1/32 ,  A61N1/36

CPC classification number: A61N1/0476 ,  A61N1/328 ,  A61N1/36034 ,  A61B2018/00732

Abstract: Methods and apparatuses are described herein for inactivation of bacterial biofilms using sub-microsecond pulsed electric field application to an affected surface or region. In some examples, a bacterial biofilm may be inactivated while planktonic bacteria in the vicinity of the biofilm are not inactivated. These methods and systems provide an electrical-based therapeutic modality for which bacteria in biofilms may have difficulty developing resistance, unlike antibiotic therapies.

公开(公告)号：US11672594B2

公开(公告)日：2023-06-13

申请号：US17006406

申请日：2020-08-28

Applicant: Old Dominion University Research Foundation

Inventor： Christian W. Zemlin

IPC: A61B18/14 ,  A61B18/00

CPC classification number: A61B18/1492 ,  A61B18/1477 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/00613

Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.

公开(公告)号：US10982206B2

公开(公告)日：2021-04-20

申请号：US15972856

申请日：2018-05-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Olga Pakhomova ,  Andrei G. Pakhomov

IPC: C12N13/00 ,  A61N1/32

Abstract: Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.

公开(公告)号：US20200147371A1

公开(公告)日：2020-05-14

申请号：US16669419

申请日：2019-10-30

Applicant: Old Dominion University Research Foundation

Inventor： Andrei G. PAKHOMOV ,  Shu XIAO ,  Olga N. PAKHOMOVA ,  Maura CASCIOLA

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/08

Abstract: Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.

公开(公告)号：US20180110978A1

公开(公告)日：2018-04-26

申请号：US15559324

申请日：2016-03-18

Applicant: Old Dominion University Research Foundation

Inventor： Stephen J. BEEBE ,  John D. CATRAVAS

IPC: A61N1/36 ,  A61K31/395 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61N1/36002 ,  A61K31/395 ,  A61K45/06 ,  A61N1/0412 ,  A61N1/327 ,  A61N1/36014 ,  A61P35/00

Abstract: Methods for treating tumors employing HSp90 inhibitors in combination with nanosecond pulsed electric fields (nsPEFs) are disclosed. The methods are directed to induce regulated cell death (RCD) in tumor cells and tissues. Further, Hsp90 inhibitors in combination with nsPEF are used at low non-toxic concentrations, thereby reducing the side-effects associated with these drugs. Additionally, nsPEFs are employed at lower electric fields and/or with fewer number of pulses than when nsPEFs are employed alone. Further, the mechanisms by which nsPEFs and Hsp90 inhibitors act upon cancer cells are different, thereby combining these treatments results in a synergistic effect.

公开(公告)号：US20180050215A1

公开(公告)日：2018-02-22

申请号：US15554808

申请日：2016-03-02

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Andrei G. PAKHOMOV ,  Christian W. ZEMLIN

IPC: A61N1/39

CPC classification number: A61N1/3906 ,  A61N1/327

Abstract: Methods for terminating fibrillation in a fibrillating heart employing nanosecond pulsed electric fields (nsPEFs) are disclosed. nsPEF defibrillation demonstrates its effectiveness as a new defibrillation modality, achieving reliable defibrillation with energies that are an order of magnitude lower than those needed for conventional defibrillation (millisecond shocks with mono- and bi-phasic waveforms). Tests did not reveal any negative effect of nsPEF defibrillation on cardiac tissue, in particular, cardiac tissue treated with nsPEFs does not exhibit a baseline shift in the optical transmembrane potential signal (distinctive feature that indicates electroporation), or changes in action potential duration or shape. The mechanism of nsPEF defibrillation is likely different from conventional defibrillation since it does not rely on membrane charging but on the basis of displacement currents that flow within nanoseconds after the shock is applied. nsPEFs provide the technology for the next generation of defibrillators that help emergency medical services to treat patients effectively.

公开(公告)号：US20140364797A1

公开(公告)日：2014-12-11

申请号：US14366909

申请日：2012-12-20

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. Schoenbach ,  Richard Heller ,  James Camp ,  Stephen P. Beebe ,  Shu Xiao ,  Amy Donate

IPC: A61B18/12 ,  A61N5/02 ,  A61N5/06 ,  A61N1/32 ,  A61N5/00

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.

Abstract translation: 用于治疗包含靶组织和其他组织的生物组织的系统和方法。 所述方法包括将目标组织的温度升高到生物组织的生理温度以上至处理温度，并且使用预定义的施加在at之间的短电压脉冲序列产生延伸穿过目标组织的至少一部分的电场 至少两个电极。 在该方法中，在生成期间维持处理温度。 此外，预定义的序列被选择为使得所产生的电场的量值足以在目标组织的部分中诱导电动势，而不会使目标组织的部分的温度基本上升高到处理温度以上。

公开(公告)号：US20140360862A1

公开(公告)日：2014-12-11

申请号：US14362181

申请日：2012-12-03

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Muhammad Arif Malik ,  Karl H. Schoenbach

IPC: B01J12/00 ,  G21F9/02 ,  H05B6/46 ,  B01J19/08 ,  C07C37/00

CPC classification number: B01J12/002 ,  B01J8/0242 ,  B01J19/088 ,  B01J2219/0809 ,  B01J2219/0811 ,  B01J2219/0828 ,  B01J2219/083 ,  B01J2219/0841 ,  B01J2219/0849 ,  B01J2219/0871 ,  B01J2219/0875 ,  B01J2219/0883 ,  B01J2219/0888 ,  B01J2219/0892 ,  B01J2219/0894 ,  C01B3/342 ,  C01B4/00 ,  C01B15/01 ,  C01B2203/0861 ,  C07C37/00 ,  G21F9/02 ,  H05B6/46 ,  Y02E60/36

Abstract: Gas treatment systems and methods are provided. A system includes at least one device defining a space and having a gas inlet and a gas outlet. The device also includes an electrode assembly, where the electrode assembly includes a dielectric plate, at least one first electrode, at least one second electrode, and a conductive layer. The electrodes are elongate electrodes disposed on a first major surface of the dielectric plate and arranged substantially in parallel. Further, the conductive layer extends over a second major surface of the dielectric plate, is electrically coupled to the one of the electrodes, and is electrically isolated from the other electrode. The system includes a circuit configured for generating a pulsed electric field between the electrodes.

Abstract translation: 提供了气体处理系统和方法。 一种系统包括至少一个限定空间并具有气体入口和气体出口的装置。 该装置还包括电极组件，其中电极组件包括电介质板，至少一个第一电极，至少一个第二电极和导电层。 电极是设置在电介质板的第一主表面上并且基本上平行布置的细长电极。 此外，导电层在电介质板的第二主表面上延伸，电耦合到电极之一，并且与另一个电极电隔离。 该系统包括被配置为在电极之间产生脉冲电场的电路。

公开(公告)号：US20140331993A1

公开(公告)日：2014-11-13

申请号：US14270839

申请日：2014-05-06

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION ,  TYTON BIOSCIENCES

Inventor： Sandeep KUMAR ,  Jose Luis Garcia MOSCOSO ,  Iulian BOBE ,  Peter MAJERANOWSKI

IPC: C13K1/02 ,  C07D401/04

CPC classification number: C13K1/04 ,  A24B7/00 ,  A24B15/24 ,  A24B15/243 ,  C07D401/04 ,  C08H8/00 ,  C11B1/10 ,  C13K1/02

Abstract: Processes for recovering sugars and nicotine from a tobacco biomass include feeding a biomass of tobacco plants and subcritical water to a reactor, hydrolyzing the biomass of tobacco plants with the subcritical water at a temperature between about 150° C. and 305° C. and recovering a liquid product and a solid product from the reactor, wherein the liquid product contains water-soluble sugars and nicotine.

Abstract translation: 从烟草生物质回收糖和尼古丁的方法包括将烟草植物和亚临界水的生物质进料到反应器中，在约150℃至305℃的温度下用亚临界水水解烟草植物的生物量并回收 液体产物和来自反应器的固体产物，其中液体产物含有水溶性糖和尼古丁。