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    DNA encoding a CCK-8S G-protein coupled receptor, and vectors, transformants, cell kits, and methods employing such DNA
    1.
    发明授权
    DNA encoding a CCK-8S G-protein coupled receptor, and vectors, transformants, cell kits, and methods employing such DNA 有权
    编码CCK-8S G蛋白偶联受体的DNA和载体，转化体，细胞试剂盒和使用这种DNA的方法

    公开(公告)号：US07977069B2

    公开(公告)日：2011-07-12

    申请号：US12409847

    申请日：2009-03-24

    申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

    发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

    IPC分类号： C12N15/12 ,  C07K14/00

    CPC分类号： G01N33/74 ,  G01N2333/726

    摘要： DNA encoding a cholecystokinin octapeptide sulfated form (CCK-8S) G-protein coupled receptor, a complementary strand thereof, a vector containing the DNA, a transformant containing the vector, a pharmaceutical composition, and a reagent kit are provided. Such DNA and constructs are useful in identifying a compound that inhibits or promotes a function of the protein and/or expression of a DNA encoding the protein. Such DNA and constructs are also useful for identifying an anti-depressant drug or a compound that has an anti-depressant action.

    摘要翻译： 提供编码缩胆囊素八肽硫酸盐形式的DNA（CCK-8S）G蛋白偶联受体，其互补链，含有载体的载体，含有载体的转化体，药物组合物和试剂盒。 这样的DNA和构建体可用于鉴定抑制或促进蛋白质的功能和/或表达编码该蛋白质的DNA的化合物。 这样的DNA和构建体也可用于鉴定抗抑郁药或具有抗抑郁作用的化合物。

    Method For Identification of Compound Having Anti-Anxiety Effect
    2.
    发明申请
    Method For Identification of Compound Having Anti-Anxiety Effect 审中-公开
    用于鉴定具有抗焦虑作用的化合物的方法

    公开(公告)号：US20100029702A1

    公开(公告)日：2010-02-04

    申请号：US12447979

    申请日：2007-11-01

    申请人： Daisuke Okajima ,  Hiroshi Yokota ,  Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi

    发明人： Daisuke Okajima ,  Hiroshi Yokota ,  Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi

    IPC分类号： C12Q1/68 ,  A61K31/438 ,  A61P25/22

    CPC分类号： C12Q1/6883 ,  A01K2267/0356 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N2800/301

    摘要： There are provided a method for identifying a compound having an anti-anxiety effect, an inhibitor of a function of a protein having a function as a G-protein coupled receptor, characterized by finding the protein and a gene encoding the protein and using at least one of a DNA represented by the nucleotide sequence of this gene or a complementary strand thereof, a homologue of the DNA, a protein encoded by the DNA, and a cell expressing the protein encoded by the DNA, an agent and a method for improving an anxiety condition, a method and an agent for prophylactic and/or therapeutic treatment of an anxiety disorder, and a measurement method for diagnosis and a diagnostic method of an anxiety disorder.

    摘要翻译： 提供了鉴定具有抗焦虑作用的化合物的方法，具有作为G蛋白偶联受体的功能的蛋白质的功能抑制剂，其特征在于找到蛋白质和编码该蛋白质的基因，并至少使用 由该基因的核苷酸序列或其互补链所代表的DNA，DNA的同系物，由DNA编码的蛋白质和表达由DNA编码的蛋白质的细胞之一，药剂和改善其的方法 焦虑症，焦虑症的预防和/或治疗方法和药剂，以及焦虑障碍的诊断和诊断方法的测定方法。

    Gene Encoding G-Protein Coupled Receptor And Gene Product Thereof
    3.
    发明申请
    Gene Encoding G-Protein Coupled Receptor And Gene Product Thereof 审中-公开
    基因编码G蛋白偶联受体及其基因产物

    公开(公告)号：US20110223175A1

    公开(公告)日：2011-09-15

    申请号：US13113157

    申请日：2011-05-23

    申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

    发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P25/28 ,  A61P25/24

    CPC分类号： G01N33/74 ,  G01N2333/726

    摘要： The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful mean for preventing and/or treating diseases related to the gene and the protein, provides a DNA comprising base sequence described in SEQ ID NO: 1 or complementary strand thereof, complementary strand of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent for improving and a method for improving depression state, a pharmaceutical composition, and a reagent kit.

    摘要翻译： 本发明的目的是找出编码具有与G蛋白偶联受体（GPCR）和蛋白质相同功能的蛋白质的基因，并提供一种鉴定调节功能的化合物和/ 或蛋白质的表达，并且为预防和/或治疗与该基因和蛋白质相关的疾病提供有用的平均值，提供包含SEQ ID NO：1或其互补链中所述的碱基序列的DNA，DNA的互补链 ，由DNA编码的蛋白质，含有该载体的载体，含有该载体的转化子，针对该蛋白质的抗体，使用上述成员鉴定调节蛋白质的功能和/或表达的化合物的方法，改善剂 以及改善抑郁状态的方法，药物组合物和试剂盒。

    Gene encoding G-protein coupled receptor and gene product thereof
    4.
    发明申请
    Gene encoding G-protein coupled receptor and gene product thereof 有权
    基因编码G蛋白偶联受体及其基因产物

    公开(公告)号：US20060234305A1

    公开(公告)日：2006-10-19

    申请号：US11436904

    申请日：2006-05-18

    申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

    发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

    IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： G01N33/74 ,  G01N2333/726

    摘要： The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful mean for preventing and/or treating diseases related to the gene and the protein, provides a DNA comprising base sequence described in SEQ ID NO: 1 or complementary strand thereof, complementary strand of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent for improving and a method for improving depression state, a pharmaceutical composition, and a reagent kit.

    摘要翻译： 本发明的目的是找出编码具有与G蛋白偶联受体（GPCR）和蛋白质相同功能的蛋白质的基因，并提供一种鉴定调节功能的化合物和/ 或蛋白质的表达，并且为预防和/或治疗与该基因和蛋白质相关的疾病提供有用的平均值，提供包含SEQ ID NO：1或其互补链中所述的碱基序列的DNA，DNA的互补链 ，由DNA编码的蛋白质，含有该载体的载体，含有该载体的转化子，针对该蛋白质的抗体，使用上述成员鉴定调节蛋白质的功能和/或表达的化合物的方法，改善剂 以及改善抑郁状态的方法，药物组合物和试剂盒。

    Gene Encoding G-Protein Coupled Receptor and Gene Product Thereof
    5.
    发明申请
    Gene Encoding G-Protein Coupled Receptor and Gene Product Thereof 有权
    基因编码G蛋白偶联受体及其基因产物

    公开(公告)号：US20090203073A1

    公开(公告)日：2009-08-13

    申请号：US12409847

    申请日：2009-03-24

    申请人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

    发明人： Osamu Ohara ,  Takahiro Nagase ,  Michio Ohishi ,  Daisuke Okajima ,  Hiroshi Yokota

    IPC分类号： C12P21/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06

    CPC分类号： G01N33/74 ,  G01N2333/726

    摘要： The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful mean for preventing and/or treating diseases related to the gene and the protein, provides a DNA comprising base sequence described in SEQ ID NO: 1 or complementary strand thereof, complementary strand of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent for improving and a method for improving depression state, a pharmaceutical composition, and a reagent kit.

    摘要翻译： 本发明的目的是找出编码具有与G蛋白偶联受体（GPCR）和蛋白质相同功能的蛋白质的基因，并提供一种鉴定调节功能的化合物和/ 或蛋白质的表达，并且为预防和/或治疗与该基因和蛋白质相关的疾病提供有用的平均值，提供包含SEQ ID NO：1或其互补链中所述的碱基序列的DNA，DNA的互补链 ，由DNA编码的蛋白质，含有该载体的载体，含有该载体的转化子，针对该蛋白质的抗体，使用上述成员鉴定调节蛋白质的功能和/或表达的化合物的方法，改善剂 以及改善抑郁状态的方法，药物组合物和试剂盒。