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    METHOD FOR REDUCING IMAGE ARTIFACTS PRODUCED BY A CMOS CAMERA
    1.
    发明申请
    METHOD FOR REDUCING IMAGE ARTIFACTS PRODUCED BY A CMOS CAMERA 有权
    降低由CMOS相机产生的图像制品的方法

    公开(公告)号：US20130129212A1

    公开(公告)日：2013-05-23

    申请号：US13813197

    申请日：2011-07-19

    申请人： Pavel A. Fomitchov ,  Witold Bula ,  Carlos Zarate ,  Yang Zhang

    发明人： Pavel A. Fomitchov ,  Witold Bula ,  Carlos Zarate ,  Yang Zhang

    IPC分类号： G06T5/00

    CPC分类号： G06T5/00 ,  G06T5/005 ,  H04N1/409 ,  H04N5/357

    摘要： The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.

    摘要翻译： 本发明涉及一种用于减少用作线共焦荧光成像仪的光学检测器的CMOS相机的图像伪影的系统和方法。 用于减少单色图像中的图像伪像的方法包括减去RGB信道偏移不匹配; 并校正每行的随机行偏移量。 优选地，该方法还包括校正随机列偏移和增益。 可选地，该方法还包括限制缺陷像素和/或减去暗电流。 当单色图像是荧光图像时，该方法还包括压缩CMOS相机噪声的步骤。 还提供了一种用于减少来自CMOS照相机的单色图像中的图像伪影的系统，以及用于基于CMOS照相机的线共聚焦荧光显微镜的图像伪像减少系统。

    Method for reducing image artifacts produced by a CMOS camera
    2.
    发明授权
    Method for reducing image artifacts produced by a CMOS camera 有权
    降低CMOS相机产生的图像伪影的方法

    公开(公告)号：US09373158B2

    公开(公告)日：2016-06-21

    申请号：US13813197

    申请日：2011-07-19

    申请人： Pavel A. Fomitchov ,  Witold Bula ,  Carlos Zarate ,  Yang Zhang

    发明人： Pavel A. Fomitchov ,  Witold Bula ,  Carlos Zarate ,  Yang Zhang

    IPC分类号： G06K9/00 ,  G06T5/00 ,  H04N1/409 ,  H04N5/357

    CPC分类号： G06T5/00 ,  G06T5/005 ,  H04N1/409 ,  H04N5/357

    摘要： The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.

    摘要翻译： 本发明涉及一种用于减少用作线共焦荧光成像仪的光学检测器的CMOS相机的图像伪影的系统和方法。 用于减少单色图像中的图像伪像的方法包括减去RGB信道偏移不匹配; 并校正每行的随机行偏移量。 优选地，该方法还包括校正随机列偏移和增益。 可选地，该方法还包括限制缺陷像素和/或减去暗电流。 当单色图像是荧光图像时，该方法还包括压缩CMOS相机噪声的步骤。 还提供了一种用于减少来自CMOS照相机的单色图像中的图像伪影的系统，以及用于基于CMOS照相机的线共聚焦荧光显微镜的图像伪像减少系统。

    MICROSCOPY SYSTEM AND METHOD FOR BIOLOGICAL IMAGING
    5.
    发明申请
    MICROSCOPY SYSTEM AND METHOD FOR BIOLOGICAL IMAGING 审中-公开
    用于生物成像的微观系统和方法

    公开(公告)号：US20140140595A1

    公开(公告)日：2014-05-22

    申请号：US14129640

    申请日：2012-06-27

    申请人： Pavel A. Fomitchov ,  Witold Bula

    发明人： Pavel A. Fomitchov ,  Witold Bula

    IPC分类号： G02B21/36 ,  G06T7/00

    CPC分类号： G02B21/365 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/16 ,  G06T7/0012

    摘要： Microscopy system for biological imaging, comprising an image quality monitoring system for monitoring image quality of an image of a biological sample comprising a biological object selection means arranged to let a user of the system to select one or more Biological Reference Objects (BRO) in the image of the biological sample, and an image quality evaluation means arranged to compare the signal level of image pixels of the one or more BROs with an image background signal level to calculate one or more image quality parameters for the image of the biological sample. The system is arranged to present the image quality parameters to the user as an indication of the image quality specific for the BRO(s).

    摘要翻译： 用于生物成像的显微镜系统，包括用于监测生物样品的图像的图像质量的图像质量监测系统，所述图像质量监测系统包括生物物体选择装置，所述生物物体选择装置被布置为使得所述系统的用户选择所述生物样本中的一个或多个生物参考对象 图像质量评估装置，其被布置为将一个或多个BRO的图像像素的信号电平与图像背景信号电平进行比较，以计算生物样本的图像的一个或多个图像质量参数。 系统被布置为向用户呈现图像质量参数作为对BRO特有的图像质量的指示。

    IMAGE QUALITY OPTIMIZATION OF BIOLOGICAL IMAGING
    6.
    发明申请
    IMAGE QUALITY OPTIMIZATION OF BIOLOGICAL IMAGING 审中-公开
    图像质量优化生物成像

    公开(公告)号：US20140152800A1

    公开(公告)日：2014-06-05

    申请号：US14129699

    申请日：2012-06-27

    申请人： Pavel A. Fomitchov ,  Witold Bula

    发明人： Pavel A. Fomitchov ,  Witold Bula

    IPC分类号： G01N21/64 ,  G02B21/36

    CPC分类号： G01N21/6458 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/16 ,  G02B21/365

    摘要： Microscopy system for biological imaging, comprising an image quality optimizer for optimizing image quality of an image of a biological sample, allowing a user to select an optimization mode from a list of functionally defined optimization modes, and wherein the system is arranged to automatically set one or more image acquisition parameters to achieve optimal imaging for the selected optimization mode based on at least one image quality parameter derived from one or more Biological Reference Objects (BRO) in the image of the biological sample selected by the user or automatically by the system.

    摘要翻译： 用于生物成像的显微镜系统，包括用于优化生物样品的图像的图像质量的图像质量优化器，允许用户从功能定义的优化模式列表中选择优化模式，并且其中所述系统被布置成自动设置一个 或更多的图像采集参数，以基于从用户选择的或由系统自动选择的生物样品的图像中的一个或多个生物参考对象（BRO）导出的至少一个图像质量参数来实现所选优化模式的最佳成像。

    Method and apparatus for fluorescent confocal microscopy
    7.
    发明授权
    Method and apparatus for fluorescent confocal microscopy 有权
    荧光共焦显微镜的方法和装置

    公开(公告)号：US07335898B2

    公开(公告)日：2008-02-26

    申请号：US11184444

    申请日：2005-07-19

    申请人： Paul Donders ,  Carlos Zarate ,  Pavel A. Fomitchov

    发明人： Paul Donders ,  Carlos Zarate ,  Pavel A. Fomitchov

    IPC分类号： G01N21/64

    CPC分类号： G02B21/0076 ,  G02B21/0036 ,  G02B21/0064 ,  G02B21/0084

    摘要： A new and improved confocal fluorescence microscope is presented. The new microscope has significant advantages relative to existing implementations of microscope confocal imagers. In common with previous confocal imagers the instant invention has the advantages relative to conventional wide-field and confocal fluorescence imagers, however it addresses the drawbacks of confocal technology in terms of cost and complexity, and provides significant savings in both due to the simplicity of the components and the elimination of the need of, in particular, spatial filters such as pinholes or slits.

    摘要翻译： 提出了一种新的改进的共焦荧光显微镜。 新显微镜相对于现有的显微镜共焦成像仪的实现具有显着的优势。 与以前的共焦成像仪相同，本发明相对于传统的宽场和共聚焦荧光成像器具有优点，但是它在成本和复杂性方面解决了共聚焦技术的缺点，并且由于简化了 组件和消除特别是诸如针孔或狭缝的空间滤波器的需要。

    System and method for adjusting the spherical aberration of objective lenses
    8.
    发明授权
    System and method for adjusting the spherical aberration of objective lenses 有权
    用于调整物镜球面像差的系统和方法

    公开(公告)号：US08053711B2

    公开(公告)日：2011-11-08

    申请号：US12523066

    申请日：2008-01-28

    申请人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

    发明人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

    IPC分类号： G02B7/04

    CPC分类号： G02B27/0068

    摘要： A spherical aberration adjustment system is disclosed, which includes a plurality of objective lenses, where at least one of the plurality of objective lenses has a spherical aberration collar. The plurality of objective lenses are mounted onto an objective holder, where the objective holder is configured to place the at least one of the plurality of objective lenses in an imaging position. A driving mechanism is coupled by a mechanical link to the at least one of the plurality of objective lenses, where the mechanical link is configured to transmit motion from the driving mechanism to the spherical aberration collar. A control system is configured to manipulate the driving mechanism to move the spherical aberration collar of the at least one of the plurality of objective lenses in the imaging position to a specific spherical aberration adjustment setting.

    摘要翻译： 公开了一种球面像差调整系统，其包括多个物镜，其中多个物镜中的至少一个具有球面像差轴环。 多个物镜安装在物镜支架上，其中物镜支架构造成将多个物镜中的至少一个放置在成像位置。 驱动机构通过机械连杆耦合到多个物镜中的至少一个物镜，其中机械连杆构造成将运动从驱动机构传递到球面像差轴环。 控制系统被配置为操纵驱动机构以将成像位置中的多个物镜中的至少一个的球面像差轴环移动到特定的球面像差调整设置。

    SYSTEM AND METHOD FOR ADJUSTING THE SPHERICAL ABERRATION OF OBJECTIVE LENSES
    9.
    发明申请
    SYSTEM AND METHOD FOR ADJUSTING THE SPHERICAL ABERRATION OF OBJECTIVE LENSES 有权
    用于调整目标镜片的球面抛光的系统和方法

    公开(公告)号：US20100033812A1

    公开(公告)日：2010-02-11

    申请号：US12523066

    申请日：2008-01-28

    申请人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

    发明人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

    IPC分类号： G02B7/09 ,  G02B7/14 ,  G02B21/02

    CPC分类号： G02B27/0068

    摘要： A spherical aberration adjustment system is disclosed, which includes a plurality of objective lenses, where at least one of the plurality of objective lenses has a spherical aberration collar. The plurality of objective lenses are mounted onto an objective holder, where the objective holder is configured to place the at least one of the plurality of objective lenses in an imaging position. A driving mechanism is coupled by a mechanical link to the at least one of the plurality of objective lenses, where the mechanical link is configured to transmit motion from the driving mechanism to the spherical aberration collar. A control system is configured to manipulate the driving mechanism to move the spherical aberration collar of the at least one of the plurality of objective lenses in the imaging position to a specific spherical aberration adjustment setting.

    摘要翻译： 公开了一种球面像差调整系统，其包括多个物镜，其中多个物镜中的至少一个具有球面像差轴环。 多个物镜安装在物镜支架上，其中物镜支架构造成将多个物镜中的至少一个放置在成像位置。 驱动机构通过机械连杆耦合到多个物镜中的至少一个物镜，其中机械连杆构造成将运动从驱动机构传递到球面像差轴环。 控制系统被配置为操纵驱动机构以将成像位置中的多个物镜中的至少一个的球面像差轴环移动到特定的球面像差调整设置。

    IMAGING SYSTEM FOR FLUORESCENCE GUIDED SURGERY BASED ON FIXED MAGNIFICATION LENS AND DIGITAL ZOOM
    10.
    发明申请
    IMAGING SYSTEM FOR FLUORESCENCE GUIDED SURGERY BASED ON FIXED MAGNIFICATION LENS AND DIGITAL ZOOM 审中-公开
    基于固定放大镜和数字变焦的荧光指导手术成像系统

    公开(公告)号：US20110261179A1

    公开(公告)日：2011-10-27

    申请号：US12765204

    申请日：2010-04-22

    申请人： Pavel A. Fomitchov

    发明人： Pavel A. Fomitchov

    IPC分类号： H04N7/18

    CPC分类号： H04N7/18 ,  A61B90/30 ,  A61B2090/304 ,  A61B2090/3616 ,  A61B2090/3618

    摘要： The invention relates to an imaging system for use in operating rooms and other applications. According to one example, the imaging system may include a visible light source configured to illuminate a surgical field with visible light and an excitation source configured to generate excitation light to excite a fluorescent substance in an organism within the surgical field. The imaging system may also include an imaging lens system including a first sensor configured to receive visible light reflected from the surgical field via a first spectral channel and a second sensor configured to receive a fluorescent emission emitted from the fluorescent substance in the organism via a second spectral channel. The imaging system may further include a plurality of fixed magnification lenses configured to optically couple image signals to the first sensor and the second sensor, and a control unit configured to receive and digitally process the image signals to generate a plurality of image frames in order to rescale the plurality of image frames for display to a surgeon.

    摘要翻译： 本发明涉及一种用于手术室和其他应用的成像系统。 根据一个示例，成像系统可以包括被配置为用可见光照射外科视野的可见光源和被配置为产生激发光以激发外科视野内的生物体中的荧光物质的激发源。 成像系统还可以包括成像透镜系统，该成像透镜系统包括被配置为经由第一光谱通道接收从外科视野反射的可见光的第一传感器，以及经配置以经由第二传感器接收从生物体中的荧光物质发射的荧光发射的第二传感器 频谱通道。 成像系统还可以包括多个固定放大透镜，其被配置为将图像信号光耦合到第一传感器和第二传感器，以及控制单元，被配置为接收和数字处理图像信号以产生多个图像帧，以便 重新调整多个图像帧以便显示给外科医生。