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    System and method for adjusting the spherical aberration of objective lenses
    1.
    发明授权
    System and method for adjusting the spherical aberration of objective lenses 有权
    用于调整物镜球面像差的系统和方法

    公开(公告)号：US08053711B2

    公开(公告)日：2011-11-08

    申请号：US12523066

    申请日：2008-01-28

    申请人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

    发明人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

    IPC分类号： G02B7/04

    CPC分类号： G02B27/0068

    摘要： A spherical aberration adjustment system is disclosed, which includes a plurality of objective lenses, where at least one of the plurality of objective lenses has a spherical aberration collar. The plurality of objective lenses are mounted onto an objective holder, where the objective holder is configured to place the at least one of the plurality of objective lenses in an imaging position. A driving mechanism is coupled by a mechanical link to the at least one of the plurality of objective lenses, where the mechanical link is configured to transmit motion from the driving mechanism to the spherical aberration collar. A control system is configured to manipulate the driving mechanism to move the spherical aberration collar of the at least one of the plurality of objective lenses in the imaging position to a specific spherical aberration adjustment setting.

    摘要翻译： 公开了一种球面像差调整系统，其包括多个物镜，其中多个物镜中的至少一个具有球面像差轴环。 多个物镜安装在物镜支架上，其中物镜支架构造成将多个物镜中的至少一个放置在成像位置。 驱动机构通过机械连杆耦合到多个物镜中的至少一个物镜，其中机械连杆构造成将运动从驱动机构传递到球面像差轴环。 控制系统被配置为操纵驱动机构以将成像位置中的多个物镜中的至少一个的球面像差轴环移动到特定的球面像差调整设置。

    SYSTEM AND METHOD FOR ADJUSTING THE SPHERICAL ABERRATION OF OBJECTIVE LENSES
    2.
    发明申请
    SYSTEM AND METHOD FOR ADJUSTING THE SPHERICAL ABERRATION OF OBJECTIVE LENSES 有权
    用于调整目标镜片的球面抛光的系统和方法

    公开(公告)号：US20100033812A1

    公开(公告)日：2010-02-11

    申请号：US12523066

    申请日：2008-01-28

    申请人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

    发明人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

    IPC分类号： G02B7/09 ,  G02B7/14 ,  G02B21/02

    CPC分类号： G02B27/0068

    摘要： A spherical aberration adjustment system is disclosed, which includes a plurality of objective lenses, where at least one of the plurality of objective lenses has a spherical aberration collar. The plurality of objective lenses are mounted onto an objective holder, where the objective holder is configured to place the at least one of the plurality of objective lenses in an imaging position. A driving mechanism is coupled by a mechanical link to the at least one of the plurality of objective lenses, where the mechanical link is configured to transmit motion from the driving mechanism to the spherical aberration collar. A control system is configured to manipulate the driving mechanism to move the spherical aberration collar of the at least one of the plurality of objective lenses in the imaging position to a specific spherical aberration adjustment setting.

    摘要翻译： 公开了一种球面像差调整系统，其包括多个物镜，其中多个物镜中的至少一个具有球面像差轴环。 多个物镜安装在物镜支架上，其中物镜支架构造成将多个物镜中的至少一个放置在成像位置。 驱动机构通过机械连杆耦合到多个物镜中的至少一个物镜，其中机械连杆构造成将运动从驱动机构传递到球面像差轴环。 控制系统被配置为操纵驱动机构以将成像位置中的多个物镜中的至少一个的球面像差轴环移动到特定的球面像差调整设置。

    TIME RESOLVED FLUORESCENT IMAGING SYSTEM
    4.
    发明申请
    TIME RESOLVED FLUORESCENT IMAGING SYSTEM 失效
    时间分辨率荧光成像系统

    公开(公告)号：US20100090127A1

    公开(公告)日：2010-04-15

    申请号：US12517653

    申请日：2008-01-23

    申请人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

    发明人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

    IPC分类号： G01J1/58

    CPC分类号： G01N21/6458 ,  G01N21/6408 ,  G01N2021/6439 ,  G01N2021/6441

    摘要： This invention provides a system and method that allows for time-resolved fluorescent imaging of fluorescent samples. The user is able to receive temporally filtered pictures of the sample with a reduced amount of the scattered excitation light and the short lived background fluorescence. The system allows for adjustment of fluorescent gating time and delay time.

    摘要翻译： 本发明提供允许荧光样品的时间分辨荧光成像的系统和方法。 用户能够以减少量的散射激发光和短寿命背景荧光来接收样本的时间滤波图像。 该系统允许调节荧光门控时间和延迟时间。

    System and method for multimode imaging
    5.
    发明授权
    System and method for multimode imaging 失效
    多模成像系统和方法

    公开(公告)号：US07567346B2

    公开(公告)日：2009-07-28

    申请号：US11363938

    申请日：2006-03-01

    申请人： Pavel A. Fomitchov ,  Eugene Barash ,  Ahmad Yetka ,  Joseph Masino, III

    发明人： Pavel A. Fomitchov ,  Eugene Barash ,  Ahmad Yetka ,  Joseph Masino, III

    IPC分类号： G01N21/25

    CPC分类号： G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

    摘要： A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved elative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

    摘要翻译： 公开了一种用于至少一个样品的多模成像的系统和方法。 该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。 使用选自步骤样品移动和连续样品移动的样品移动技术将至少一个样品移动到光学系统。 该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; （3）使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和（4）用检测器选择性地读取像素。

    Time resolved fluorescent imaging system
    6.
    发明授权
    Time resolved fluorescent imaging system 失效
    时间分辨荧光成像系统

    公开(公告)号：US08063386B2

    公开(公告)日：2011-11-22

    申请号：US12517653

    申请日：2008-01-23

    申请人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

    发明人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6458 ,  G01N21/6408 ,  G01N2021/6439 ,  G01N2021/6441

    摘要： A system and method that allows for time-resolved fluorescent imaging of fluorescent samples. The user is able to receive temporally filtered pictures of the sample with a reduced amount of the scattered excitation light and the short lived background fluorescence. The system allows for adjustment of fluorescent gating time and delay time.

    摘要翻译： 允许荧光样品的时间分辨荧光成像的系统和方法。 用户能够以减少量的散射激发光和短寿命背景荧光来接收样本的时间滤波图像。 该系统允许调节荧光门控时间和延迟时间。

    MICROSCOPY SYSTEM AND METHOD FOR BIOLOGICAL IMAGING
    9.
    发明申请
    MICROSCOPY SYSTEM AND METHOD FOR BIOLOGICAL IMAGING 审中-公开
    用于生物成像的微观系统和方法

    公开(公告)号：US20140140595A1

    公开(公告)日：2014-05-22

    申请号：US14129640

    申请日：2012-06-27

    申请人： Pavel A. Fomitchov ,  Witold Bula

    发明人： Pavel A. Fomitchov ,  Witold Bula

    IPC分类号： G02B21/36 ,  G06T7/00

    CPC分类号： G02B21/365 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/16 ,  G06T7/0012

    摘要： Microscopy system for biological imaging, comprising an image quality monitoring system for monitoring image quality of an image of a biological sample comprising a biological object selection means arranged to let a user of the system to select one or more Biological Reference Objects (BRO) in the image of the biological sample, and an image quality evaluation means arranged to compare the signal level of image pixels of the one or more BROs with an image background signal level to calculate one or more image quality parameters for the image of the biological sample. The system is arranged to present the image quality parameters to the user as an indication of the image quality specific for the BRO(s).

    摘要翻译： 用于生物成像的显微镜系统，包括用于监测生物样品的图像的图像质量的图像质量监测系统，所述图像质量监测系统包括生物物体选择装置，所述生物物体选择装置被布置为使得所述系统的用户选择所述生物样本中的一个或多个生物参考对象 图像质量评估装置，其被布置为将一个或多个BRO的图像像素的信号电平与图像背景信号电平进行比较，以计算生物样本的图像的一个或多个图像质量参数。 系统被布置为向用户呈现图像质量参数作为对BRO特有的图像质量的指示。

    Method for reducing image artifacts produced by a CMOS camera
    10.
    发明授权
    Method for reducing image artifacts produced by a CMOS camera 有权
    降低CMOS相机产生的图像伪影的方法

    公开(公告)号：US09373158B2

    公开(公告)日：2016-06-21

    申请号：US13813197

    申请日：2011-07-19

    申请人： Pavel A. Fomitchov ,  Witold Bula ,  Carlos Zarate ,  Yang Zhang

    发明人： Pavel A. Fomitchov ,  Witold Bula ,  Carlos Zarate ,  Yang Zhang

    IPC分类号： G06K9/00 ,  G06T5/00 ,  H04N1/409 ,  H04N5/357

    CPC分类号： G06T5/00 ,  G06T5/005 ,  H04N1/409 ,  H04N5/357

    摘要： The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.

    摘要翻译： 本发明涉及一种用于减少用作线共焦荧光成像仪的光学检测器的CMOS相机的图像伪影的系统和方法。 用于减少单色图像中的图像伪像的方法包括减去RGB信道偏移不匹配; 并校正每行的随机行偏移量。 优选地，该方法还包括校正随机列偏移和增益。 可选地，该方法还包括限制缺陷像素和/或减去暗电流。 当单色图像是荧光图像时，该方法还包括压缩CMOS相机噪声的步骤。 还提供了一种用于减少来自CMOS照相机的单色图像中的图像伪影的系统，以及用于基于CMOS照相机的线共聚焦荧光显微镜的图像伪像减少系统。