公开(公告)号：US11649499B2

公开(公告)日：2023-05-16

申请号：US18058376

申请日：2022-11-23

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  G16B20/10 ,  G16B20/20 ,  G16B35/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B35/10 ,  G16B99/00 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US11456058B2

公开(公告)日：2022-09-27

申请号：US17746669

申请日：2022-05-17

Applicant: Personalis, Inc.

Inventor： Jason Harris ,  Mark R. Pratt ,  John West ,  Richard Chen ,  Ming Li

IPC: G16B30/10 ,  G06N3/12 ,  G16B30/00 ,  G16B20/00 ,  G16B20/20 ,  G16H50/00 ,  C12Q1/68

Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

公开(公告)号：US11365446B2

公开(公告)日：2022-06-21

申请号：US17507578

申请日：2021-10-21

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  G16B20/10 ,  G16B20/20 ,  G16B35/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US11155867B2

公开(公告)日：2021-10-26

申请号：US17080474

申请日：2020-10-26

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  G16B20/20 ,  G16B35/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B35/00 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  G16B20/10 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US10450611B2

公开(公告)日：2019-10-22

申请号：US15793845

申请日：2017-10-25

Applicant: Personalis, Inc.

Inventor： John West ,  Christian Haudenschild ,  Richard Chen

IPC: C12Q1/68 ,  C12Q1/6883 ,  G16B30/00 ,  G06N3/12 ,  C12Q1/6853 ,  C12Q1/6869 ,  G16B99/00 ,  G16B20/00

Abstract: The present disclosure provides methods and systems for personalized genetic testing of a subject. In some embodiments, a sequencing assay is performed on a biological sample from the subject, which then leads to genetic information related to the subject. Next, nucleic acid molecules are array-synthesized or selected based on the genetic information derived from data of the sequencing assay. At least some of the nucleic acid molecules may then be used in an assay which may provide additional information on one or more biological samples from the subject or a biological relative of the subject.

公开(公告)号：US20160362743A1

公开(公告)日：2016-12-15

申请号：US15222875

申请日：2016-07-28

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/68 ,  G06F19/22 ,  G06F19/18

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6869 ,  C40B50/02 ,  G06F19/10 ,  G06F19/18 ,  G06F19/22

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US20160019341A1

公开(公告)日：2016-01-21

申请号：US14871020

申请日：2015-09-30

Applicant: Personalis, Inc.

Inventor： Jason Harris ,  Mark R. Pratt ,  John West ,  Richard Chen ,  Ming Li

IPC: G06F19/22

CPC classification number: G06F19/22 ,  C12Q1/68 ,  G06F19/18 ,  G06N3/126

Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

公开(公告)号：US12258628B2

公开(公告)日：2025-03-25

申请号：US18593406

申请日：2024-03-01

Applicant: Personalis, Inc.

Inventor： John West ,  Christian Haudenschild ,  Richard Chen

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B20/00 ,  G16B30/00 ,  G16B35/00 ,  G16B99/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US20240392368A1

公开(公告)日：2024-11-28

申请号：US18626998

申请日：2024-04-04

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B35/00 ,  G16B35/10 ,  G16B99/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US20230227906A1

公开(公告)日：2023-07-20

申请号：US18179582

申请日：2023-03-07

Applicant: Personalis, Inc.

Inventor： John West ,  Christian Haudenschild ,  Richard Chen

IPC: C12Q1/6874 ,  G16B99/00 ,  G16B20/00 ,  G16B30/00 ,  C12Q1/6806

CPC classification number: C12Q1/6874 ,  G16B99/00 ,  G16B20/00 ,  G16B30/00 ,  C12Q1/6806 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.