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1.发明申请Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers 有权针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性公开(公告)号：US20050175615A1
公开(公告)日：2005-08-11
申请号：US10902276
申请日：2004-07-30
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： A61K39/0005 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018
摘要： The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein, each peptide being combined with several molecules of fatty acid containing a carbon chain of between C12 and C24 so as to allow, under suitable administration conditions, the induction of anti-P-170 antibodies. The invention relates to said composition for defining means for treating multidrug resistances.
摘要翻译： 本发明涉及免疫原性组合物，其首先包括载体，其次，作为抗原结构，包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物，各自 肽与几个含有C12和C24之间的碳链的脂肪酸分子组合，以便在合适的施用条件下允许诱导抗P-170抗体。 本发明涉及用于定义用于治疗多药耐药性的装置的所述组合物。
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2.发明申请公开(公告)号：US20050244419A1
公开(公告)日：2005-11-03
申请号：US11038501
申请日：2005-01-21
IPC分类号： A61K39/00
CPC分类号： A61K39/0005 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018
摘要： The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein, each peptide being combined with several molecules of fatty acid containing a carbon chain of between C12 and C24 so as to allow, under suitable administration conditions, the induction of anti-P-170 antibodies. The invention relates to said composition for defining means for treating multidrug resistances.
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3.发明申请Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers 审中-公开针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性公开(公告)号：US20050255561A1
公开(公告)日：2005-11-17
申请号：US11059633
申请日：2005-02-16
IPC分类号： A61K39/00 , C07H21/04 , C07K14/705 , C12P21/06
CPC分类号： A61K39/0005 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018
摘要： The invention relates to conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein. The peptide may be covalently attached to spacers which may be polyethyleneglycol (PEG), polyglycine, polylysine or any polymer chain suitable for human use and is coupled at its free end to a phospholipids, e.g., phosphatidylethanolamine or any other chemically suitable phospholipid.
摘要翻译： 本发明涉及包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物。 肽可以共价连接到可以是聚乙二醇（PEG），聚甘氨酸，聚赖氨酸或适于人类使用的任何聚合物链的间隔物上，并且其自由端与磷脂例如磷脂酰乙醇胺或任何其它化学上合适的磷脂偶联。
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4.发明申请Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers 审中-公开针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性公开(公告)号：US20060233758A1
公开(公告)日：2006-10-19
申请号：US11274885
申请日：2005-11-16
CPC分类号： A61K39/0011 , A61K9/127 , A61K39/00 , A61K39/0005 , A61K47/646 , A61K48/00 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018 , C07K16/30 , C12N5/06 , G01N33/574
摘要： The invention relates to conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein. The peptide may be covalently attached to spacers which may be polyethyleneglycol (PEG), polyglycine, polylysine or any polymer chain suitable for human use and is coupled at its free end to a phospholipids, e.g., phosphatidylethanolamine or any other chemically suitable phospholipid.
摘要翻译： 本发明涉及包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物。 肽可以共价连接到可以是聚乙二醇（PEG），聚甘氨酸，聚赖氨酸或适于人类使用的任何聚合物链的间隔物上，并且其自由端与磷脂例如磷脂酰乙醇胺或任何其它化学上合适的磷脂偶联。
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5.发明授权Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers 有权针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性公开(公告)号：US08409580B2
公开(公告)日：2013-04-02
申请号：US12870893
申请日：2010-08-30
CPC分类号： A61K39/0005 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018
摘要： The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein, each peptide being combined with several molecules of fatty acid containing a carbon chain of between C12 and C24 so as to allow, under suitable administration conditions, the induction of anti-P-170 antibodies.The invention relates to said composition for defining means for treating multidrug resistances.
摘要翻译： 本发明涉及免疫原性组合物，其首先包括载体，其次，作为抗原结构，包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物，各自 肽与几个含有C12和C24之间的碳链的脂肪酸分子组合，以便在合适的施用条件下允许诱导抗P-170抗体。 本发明涉及用于定义用于治疗多药耐药性的装置的所述组合物。
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6.发明授权Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers 有权针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性公开(公告)号：US07807171B2
公开(公告)日：2010-10-05
申请号：US10902276
申请日：2004-07-30
IPC分类号： A61K38/00
CPC分类号： A61K39/0005 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018
摘要： The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein, each peptide being combined with several molecules of fatty acid containing a carbon chain of between C12 and C24 so as to allow, under suitable administration conditions, the induction of anti-P-170 antibodies.The invention relates to said composition for defining means for treating multidrug resistances.
摘要翻译： 本发明涉及免疫原性组合物，其首先包括载体，其次，作为抗原结构，包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物，各自 肽与几个含有C12和C24之间的碳链的脂肪酸分子组合，以便在合适的施用条件下允许诱导抗P-170抗体。 本发明涉及用于定义用于治疗多药耐药性的装置的所述组合物。
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公开(公告)号：US20100297132A1
公开(公告)日：2010-11-25
申请号：US12589570
申请日：2009-10-23
申请人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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公开(公告)号：US07772375B2
公开(公告)日：2010-08-10
申请号：US11637213
申请日：2006-12-11
申请人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： C07K16/18 , C12N5/12 , A61K39/395 , A61K31/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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公开(公告)号：US20070166311A1
公开(公告)日：2007-07-19
申请号：US11637213
申请日：2006-12-11
申请人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供新的方法和组合物，其包含具有特异性识别和结合来自β-淀粉样蛋白范围的特异性表位的能力的高度特异性和高效抗体。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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10.发明申请公开(公告)号：US20120003161A1
公开(公告)日：2012-01-05
申请号：US13212612
申请日：2011-08-18
IPC分类号： A61K31/6615 , A61K8/55 , A61P35/00 , A61K9/12
CPC分类号： A61K31/6615 , A61K9/0019
摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate to enhance PO2 in hypoxic tumors.
摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸肌酸在缺氧性肿瘤中增强PO2的用途。
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