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1.发明申请Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers 有权针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性公开(公告)号：US20050175615A1
公开(公告)日：2005-08-11
申请号：US10902276
申请日：2004-07-30
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： A61K39/0005 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018
摘要： The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein, each peptide being combined with several molecules of fatty acid containing a carbon chain of between C12 and C24 so as to allow, under suitable administration conditions, the induction of anti-P-170 antibodies. The invention relates to said composition for defining means for treating multidrug resistances.
摘要翻译： 本发明涉及免疫原性组合物，其首先包括载体，其次，作为抗原结构，包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物，各自 肽与几个含有C12和C24之间的碳链的脂肪酸分子组合，以便在合适的施用条件下允许诱导抗P-170抗体。 本发明涉及用于定义用于治疗多药耐药性的装置的所述组合物。
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2.发明申请公开(公告)号：US20050244419A1
公开(公告)日：2005-11-03
申请号：US11038501
申请日：2005-01-21
IPC分类号： A61K39/00
CPC分类号： A61K39/0005 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018
摘要： The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein, each peptide being combined with several molecules of fatty acid containing a carbon chain of between C12 and C24 so as to allow, under suitable administration conditions, the induction of anti-P-170 antibodies. The invention relates to said composition for defining means for treating multidrug resistances.
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3.发明申请Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers 审中-公开针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性公开(公告)号：US20050255561A1
公开(公告)日：2005-11-17
申请号：US11059633
申请日：2005-02-16
IPC分类号： A61K39/00 , C07H21/04 , C07K14/705 , C12P21/06
CPC分类号： A61K39/0005 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018
摘要： The invention relates to conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein. The peptide may be covalently attached to spacers which may be polyethyleneglycol (PEG), polyglycine, polylysine or any polymer chain suitable for human use and is coupled at its free end to a phospholipids, e.g., phosphatidylethanolamine or any other chemically suitable phospholipid.
摘要翻译： 本发明涉及包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物。 肽可以共价连接到可以是聚乙二醇（PEG），聚甘氨酸，聚赖氨酸或适于人类使用的任何聚合物链的间隔物上，并且其自由端与磷脂例如磷脂酰乙醇胺或任何其它化学上合适的磷脂偶联。
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4.发明申请Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers 审中-公开针对P-糖蛋白170的治疗性疫苗用于抑制癌症治疗中的多药耐药性公开(公告)号：US20060233758A1
公开(公告)日：2006-10-19
申请号：US11274885
申请日：2005-11-16
CPC分类号： A61K39/0011 , A61K9/127 , A61K39/00 , A61K39/0005 , A61K47/646 , A61K48/00 , A61K2039/55505 , A61K2039/55555 , A61K2039/6018 , C07K16/30 , C12N5/06 , G01N33/574
摘要： The invention relates to conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein. The peptide may be covalently attached to spacers which may be polyethyleneglycol (PEG), polyglycine, polylysine or any polymer chain suitable for human use and is coupled at its free end to a phospholipids, e.g., phosphatidylethanolamine or any other chemically suitable phospholipid.
摘要翻译： 本发明涉及包含衍生自P-170蛋白的细胞外环的至少一种肽的全部或部分氨基酸序列的缀合物。 肽可以共价连接到可以是聚乙二醇（PEG），聚甘氨酸，聚赖氨酸或适于人类使用的任何聚合物链的间隔物上，并且其自由端与磷脂例如磷脂酰乙醇胺或任何其它化学上合适的磷脂偶联。
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公开(公告)号：US08926983B2
公开(公告)日：2015-01-06
申请号：US10590073
申请日：2005-02-22
IPC分类号： A61K39/00 , C07K14/47 , C07K16/18 , A61K39/385 , A61K9/127
CPC分类号： C07K16/18 , A61K9/127 , A61K39/0007 , A61K39/385 , A61K2039/505 , A61K2039/55555 , A61K2039/6093 , C07K14/4711 , C07K2317/10 , C07K2317/34 , C07K2317/70
摘要： The present invention comprises novel compositions and methods for eliciting high immune responses, of great specifity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P170 glycoprotein. The novel compositions of the invention comprise supramolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.
摘要翻译： 本发明包括引发高免疫应答的新型组合物和方法，具有产生构象敏感性抗体的极大特异性。 这些抗体识别多种抗原上的特异性表位，包括但不限于淀粉样蛋白，朊病毒蛋白，P170糖蛋白。 本发明的新型组合物包含通常包含肽序列的超分子抗原构建体，其共价连接于聚乙二醇化赖氨酸，导致修饰和增强的肽呈递。 本发明的独特的修饰方法适用于各种肽，并且最终可用于治疗剂型和疾病和病症如阿尔茨海默病的疫苗。
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公开(公告)号：US07772375B2
公开(公告)日：2010-08-10
申请号：US11637213
申请日：2006-12-11
申请人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： C07K16/18 , C12N5/12 , A61K39/395 , A61K31/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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公开(公告)号：US20070166311A1
公开(公告)日：2007-07-19
申请号：US11637213
申请日：2006-12-11
申请人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供新的方法和组合物，其包含具有特异性识别和结合来自β-淀粉样蛋白范围的特异性表位的能力的高度特异性和高效抗体。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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公开(公告)号：US20100297132A1
公开(公告)日：2010-11-25
申请号：US12589570
申请日：2009-10-23
申请人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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公开(公告)号：US08663650B2
公开(公告)日：2014-03-04
申请号：US10958211
申请日：2004-10-04
IPC分类号： A61K39/00
CPC分类号： C07K16/18 , A61K9/127 , A61K39/0007 , A61K39/385 , A61K2039/505 , A61K2039/55555 , A61K2039/6093 , C07K14/4711 , C07K2317/10 , C07K2317/34 , C07K2317/70
摘要： The present invention comprises novel compositions and methods for eliciting high immune responses, of great specifity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P170 glycoprotein. The novel compositions of the invention comprise supramolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.
摘要翻译： 本发明包括引发高免疫应答的新型组合物和方法，具有产生构象敏感性抗体的极大特异性。 这些抗体识别多种抗原上的特异性表位，包括但不限于淀粉样蛋白，朊病毒蛋白，P170糖蛋白。 本发明的新型组合物包含通常包含肽序列的超分子抗原构建体，其共价连接于聚乙二醇化赖氨酸，导致修饰和增强的肽呈递。 本发明的独特的修饰方法适用于各种肽，并且最终可用于治疗剂型和疾病和病症如阿尔茨海默病的疫苗。
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10.发明授权Apparatus and method for routing a dedicated number through alternate telephone carriers 有权通过备用电话载体路由专用号码的装置和方法公开(公告)号：US06292552B1
公开(公告)日：2001-09-18
申请号：US09592731
申请日：2000-06-13
申请人： William Plunkett , Laura Culli , M. Lourdes Coranado , David Hickman , Bruce A. Nance , John Simino , Mark Tamasi
发明人： William Plunkett , Laura Culli , M. Lourdes Coranado , David Hickman , Bruce A. Nance , John Simino , Mark Tamasi
IPC分类号： H04M342
CPC分类号： H04M3/42289 , H04M3/2218 , H04M3/36 , H04M15/06 , H04M15/41 , H04M15/58 , H04M15/90 , H04M2207/12 , H04M2215/016 , H04M2215/0164 , H04M2215/0188 , H04M2242/04 , H04Q3/0029 , H04Q3/66 , H04Q2213/1305 , H04Q2213/13103 , H04Q2213/13141 , H04Q2213/1325 , H04Q2213/13345 , H04Q2213/1337 , H04Q2213/13377 , H04Q2213/13383
摘要： An apparatus and method are provided for routing a call to a dedicated number through an AIN-based network. A predetermined sequence of preferred or ranked carriers is assigned to an end office from which a call originates. Input of the dedicated number at an end office number triggers the system to assign a primary carrier to connect the call based on a user selection, the local PIC, or the first carrier indicated by the predetermined sequence. An alternate and secondary carrier may also be assigned based on the predetermined sequence. The call is routed sequentially to the primary, alternate, and secondary carriers until a connection is made with the corresponding interexchange carrier until all routes are exhausted. The features of the invention are particular useful for routing calls to the Government Emergency Telecommunications Service (GETS).
摘要翻译： 提供了一种通过基于AIN的网络将呼叫路由到专用号码的装置和方法。 优选或分级的载体的预定序列被分配给来自呼叫的终端局。 在终端办公室号码处输入专用号码可触发系统根据用户选择，本地PIC或由预定序列指示的第一载波分配主载波连接呼叫。 也可以基于预定的顺序来分配备用和辅助载体。 呼叫顺序地路由到主载波，备用载波和辅载波，直到与相应的交换载波进行连接，直到所有路由耗尽为止。 本发明的特征对于将呼叫路由到政府应急通信服务（GETS）是特别有用的。
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