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公开(公告)号：US11577249B2
公开(公告)日：2023-02-14
申请号：US17236283
申请日：2021-04-21
Applicant: Plexium, Inc.
Inventor： Kandaswamy Vijayan , Andrew Boyd MacConnell , Joseph Franklin Rokicki
IPC: C40B30/06 , B01L3/00 , C12N15/10 , C12Q1/6869 , C40B50/04 , C40B50/14 , C12Q1/6876 , C40B50/16 , C40B30/04
Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
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公开(公告)号：US11998919B2
公开(公告)日：2024-06-04
申请号：US17699001
申请日：2022-03-18
Applicant: Plexium, Inc.
Inventor： Yi Zhang , Jesse Lu , Alex Price , Pengyu Yang , Kandaswamy Vijayan
CPC classification number: B01L3/5085 , C12M23/12 , B01L2200/0668 , B01L2200/12 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/0893 , B01L2300/165
Abstract: Disclosed is an assay device comprising a high density of wells aligned thereon.
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公开(公告)号：US20210394178A1
公开(公告)日：2021-12-23
申请号：US17236283
申请日：2021-04-21
Applicant: Plexium, Inc.
Inventor： Kandaswamy Vijayan , Andrew Boyd MacConnell , Joseph Franklin Rokicki
IPC: B01L3/00 , C12N15/10 , C12Q1/6869 , C40B50/04 , C40B50/14 , C12Q1/6876 , C40B30/06 , C40B50/16 , C40B30/04
Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
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公开(公告)号：US11084037B2
公开(公告)日：2021-08-10
申请号：US16140494
申请日：2018-09-24
Applicant: Plexium, Inc.
Inventor： Kandaswamy Vijayan , Andrew Boyd MacConnell , Joseph Franklin Rokicki
IPC: C40B50/16 , B01L3/00 , C12N15/10 , C12Q1/6869 , C40B50/04 , C40B50/14 , C12Q1/6876 , C40B30/06 , C40B30/04
Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
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公开(公告)号：US11027272B1
公开(公告)日：2021-06-08
申请号：US16774871
申请日：2020-01-28
Applicant: Plexium, Inc.
Inventor： Kandaswamy Vijayan , Kapil Mahakalkar , Yi Zhang
IPC: B01L3/00
Abstract: Disclosed are transfer dispensers for assay devices. These dispensers provide for transfer of a single assay component into a single well in the assay device. This ensures that the assay conducted in each well contains only a single component.
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Patent Agency Ranking
公开(公告)号：US10981170B2
公开(公告)日：2021-04-20
申请号：US16870809
申请日：2020-05-08
Applicant: Plexium, Inc.
Inventor： Kandaswamy Vijayan , Andrew Boyd MacConnell , Joseph Franklin Rokicki , Michael Van Nguyen
IPC: B01L3/00 , C12N15/10 , C12Q1/6869 , C40B50/04 , C40B50/14 , C12Q1/6876 , C40B30/06 , C40B50/16 , C40B30/04
Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
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公开(公告)号：US20190358629A1
公开(公告)日：2019-11-28
申请号：US16534886
申请日：2019-08-07
Applicant: Plexium, Inc.
Inventor： Kandaswamy Vijayan , Andrew Boyd MacConnell , Joseph Franklin Rokicki
IPC: B01L3/00 , C12N15/10 , C12Q1/6876 , C40B50/14 , C40B50/04 , C40B30/04 , C12Q1/6869 , C40B50/16 , C40B30/06
Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
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公开(公告)号：US12030057B2
公开(公告)日：2024-07-09
申请号：US18151343
申请日：2023-01-06
Applicant: Plexium, Inc.
Inventor： Kandaswamy Vijayan , Andrew Boyd MacConnell , Joseph Franklin Rokicki
IPC: C40B30/06 , B01L3/00 , C12N15/10 , C12Q1/6869 , C12Q1/6876 , C40B30/04 , C40B50/04 , C40B50/14 , C40B50/16
CPC classification number: B01L3/50853 , C12N15/1034 , C12N15/1065 , C12N15/1068 , C12N15/1075 , C12Q1/6869 , C12Q1/6876 , C40B30/04 , C40B30/06 , C40B50/04 , C40B50/14 , C40B50/16 , B01L2300/0829 , C12Q2600/16 , C12N15/1065 , C12Q2563/179
Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
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公开(公告)号：US20230234065A1
公开(公告)日：2023-07-27
申请号：US18151343
申请日：2023-01-06
Applicant: Plexium, Inc.
Inventor： Kandaswamy Vijayan , Andrew Boyd MacConnell , Joseph Franklin Rokicki
IPC: B01L3/00 , C12N15/10 , C12Q1/6869 , C40B50/04 , C40B50/14 , C12Q1/6876 , C40B30/06 , C40B50/16 , C40B30/04
CPC classification number: B01L3/50853 , C12N15/1065 , C12Q1/6869 , C40B50/04 , C40B50/14 , C12Q1/6876 , C40B30/06 , C40B50/16 , C12N15/1034 , C12N15/1068 , C12N15/1075 , C40B30/04 , C12Q2600/16 , B01L2300/0829
Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
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公开(公告)号：US20220203357A1
公开(公告)日：2022-06-30
申请号：US17699001
申请日：2022-03-18
Applicant: Plexium, Inc.
Inventor： Yi Zhang , Jesse Lu , Alex Price , Pengyu Yang , Kandaswamy Vijayan
Abstract: Disclosed is an assay device comprising a high density of wells aligned thereon.
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