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公开(公告)号：US20200340743A1
公开(公告)日：2020-10-29
申请号：US16859835
申请日：2020-04-27
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: A non-invasive method to monitor and control of lyophilization of a frozen product solution to remove solvents is disclosed which includes installing one or more wireless pressure sensors configured to fit into a lyophilization vial tray disposed in a lyophilization chamber having a plurality of product vials, wherein the wireless pressure are distributed among the product vials being lyophilized thereby providing spatial pressure variations, collecting the spatial pressure information from said wireless pressure sensors, calculating sublimation rate of the solution, and adjusting pressure and/or temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
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公开(公告)号：US20240175522A1
公开(公告)日：2024-05-30
申请号：US18389880
申请日：2023-12-20
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Anthony George Cofer , Stephen Douglas Heister
CPC classification number: F16K99/0017 , B64G1/10 , B64G1/401 , B64G1/50 , F16K99/0036 , F16K2099/0092 , F16K2099/0094
Abstract: A microfabricated valve with no moving parts. In one embodiment, the valve includes a reservoir of a liquid that is in fluid communication with an outlet channel having a throat that is less than 100 microns wide. Preferably, the channel is an elongated slit. The configuration of channel is adapted and configured such that surface tension of the liquid prevents flow out of the channel. A heater increases the temperature of the meniscus of the fluid, until a portion of the fluid is ejected from the channel. The ejection of the fluid creates both a thrusting effect and a cooling effect.
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公开(公告)号：US20230408195A1
公开(公告)日：2023-12-21
申请号：US18036067
申请日：2021-11-09
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: An environmental sensor system for monitoring nucleation in a lyophilization chamber is disclosed which includes a sensor unit, including a temperature sensor, a pressure sensor, and a reader circuit in electronic communication with the sensor unit; wherein the sensor unit is adapted to sealingly fit around a vial placed in a lyophilization chamber and further adapted to be energized by the reader circuit and provide signals associated with temperature and pressure within the vial in a non-invasive manner in which the sensors are configured to be positioned in a headspace within the vial but not in contact with product within the vial.
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公开(公告)号：US20220057018A1
公开(公告)日：2022-02-24
申请号：US17306811
申请日：2021-05-03
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Anthony George Cofer , Stephen Douglas Heister
Abstract: A microfabricated valve with no moving parts. In one embodiment, the valve includes a reservoir of a liquid that is in fluid communication with an outlet channel having a throat that is less than 100 microns wide. Preferably, the channel is an elongated slit. The configuration of channel is adapted and configured such that surface tension of the liquid prevents flow out of the channel. A heater increases the temperature of the meniscus of the fluid, until a portion of the fluid is ejected from the channel. The ejection of the fluid creates both a thrusting effect and a cooling effect.
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公开(公告)号：US20160363553A1
公开(公告)日：2016-12-15
申请号：US15183259
申请日：2016-06-15
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Andrew Strongrich
IPC: G01N27/22
CPC classification number: G01L9/00 , G01L21/26 , G01N27/226
Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.
Abstract translation: 公开了基于Knudsen热力操作的微机电（MEMS）气体传感器。 所述传感器包括基底，固定地联接到所述基底的至少一个固定组件和位于所述基底上方的至少一个可移动组件，所述至少一个可移动组件被偏置以基本上沿着主轴线移动并且与所述至少一个固定 部件。
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Patent Agency Ranking
公开(公告)号：US20220397346A1
公开(公告)日：2022-12-15
申请号：US17832372
申请日：2022-06-03
Applicant: Purdue Research Foundation , Genentech, Inc.
Inventor： Andrew Strongrich , Alina Alexeenko , Fredric John Lim , Lokesh Kumar
IPC: F26B5/06
Abstract: A lyophilization method for lyophilizing products inside one or more vials within a lyophilization chamber is disclosed which includes humidifying a charge gas to a predetermined relative humidity, cooling shelves in the lyophilization chamber to a predetermined temperature, pressurizing the chamber with the humidified charge gas to a pressurization threshold to thereby achieving a target relative humidity level within the lyophilization chamber, and suddenly releasing pressure within the lyophilization chamber until a depressurization threshold is reached in a short time interval up to about 4 seconds, during the depressurization, product inside one or more vials nucleate.
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公开(公告)号：US20220074662A1
公开(公告)日：2022-03-10
申请号：US17526080
申请日：2021-11-15
Applicant: Purdue Research Foundation
Inventor： Mukerrem Cakmak , Alina Alexeenko
Abstract: Roll-to-roll freeze-drying (lyophilization) system and process for facilitating freeze-drying processes and enabling the collection of data by which a freeze-drying process can be monitored and evaluated. Such a system includes a roll-to-roll freeze-drying apparatus adapted to continuously freeze and dry a liquid to form a freeze-dried and encapsulate freeze-dried sheet portions of the freeze-dried sheet to create premeasured pouches containing the freeze-dried sheet portions. The system further includes a metrology section that monitors any of the freeze-dried sheet and the freeze-dried sheet portions during the freezing and drying of the liquid to generate data for controlling the freezing and drying of the liquid.
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公开(公告)号：US11175092B2
公开(公告)日：2021-11-16
申请号：US16338532
申请日：2017-10-10
Applicant: Purdue Research Foundation
Inventor： Mukerrem Cakmak , Alina Alexeenko
Abstract: Roll-to-roll freeze-drying (lyophilization) system and process for facilitating freeze-drying processes and enabling the collection of data by which a freeze-drying process can be monitored and evaluated. Such a system includes a roll-to-roll freeze-drying apparatus adapted to continuously freeze and dry a liquid to form a freeze-dried and encapsulate freeze-dried sheet portions of the freeze-dried sheet to create premeasured pouches containing the freeze-dried sheet portions. The system further includes a metrology section that monitors any of the freeze-dried sheet and the freeze-dried sheet portions during the freezing and drying of the liquid to generate data for controlling the freezing and drying of the liquid.
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公开(公告)号：US20170159847A1
公开(公告)日：2017-06-08
申请号：US15370633
申请日：2016-12-06
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Anthony George Cofer , Stephen Douglas Heister
CPC classification number: F16K99/0017 , B64G1/10 , B64G1/401 , B64G1/50 , F16K99/0036 , F16K2099/0092 , F16K2099/0094
Abstract: A microfabricated valve with no moving parts. In one embodiment, the valve includes a reservoir of a liquid that is in fluid communication with an outlet channel having a throat that is less than 100 microns wide. Preferably, the channel is an elongated slit. The configuration of channel is adapted and configured such that surface tension of the liquid prevents flow out of the channel. A heater increases the temperature of the meniscus of the fluid, until a portion of the fluid is ejected from the channel. The ejection of the fluid creates both a thrusting effect and a cooling effect.
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公开(公告)号：US11867319B2
公开(公告)日：2024-01-09
申请号：US17306811
申请日：2021-05-03
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Anthony George Cofer , Stephen Douglas Heister
CPC classification number: F16K99/0017 , B64G1/10 , B64G1/401 , B64G1/50 , F16K99/0036 , F16K2099/0092 , F16K2099/0094
Abstract: A microfabricated valve with no moving parts. In one embodiment, the valve includes a reservoir of a liquid that is in fluid communication with an outlet channel having a throat that is less than 100 microns wide. Preferably, the channel is an elongated slit. The configuration of channel is adapted and configured such that surface tension of the liquid prevents flow out of the channel. A heater increases the temperature of the meniscus of the fluid, until a portion of the fluid is ejected from the channel. The ejection of the fluid creates both a thrusting effect and a cooling effect.
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