摘要:
A microfluidic device includes a three-dimensional slat structure having a plurality of interstices configured to generate a high power, high flow rate of fluids by electroosmotic flow. The microfluidic device includes a housing for holding and moving fluids through the slat structure, and a plurality of electrodes that generate an electric field within the plurality of interstices.
摘要:
An embodiment of the invention relates to a fluidic system (200) in which a first channel (210) and a second channel (230) are separated by a fluidic stop (220), for example a region with a hydrophobic coating and/or a structure (220) with non-capillary internal dimensions. Moreover, it comprises a flexible element (240) that is deformable to enable a flow of a medium across the fluidic stop.
摘要:
A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is then opened, and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface. Applications for microfluidic free interfaces in accordance with embodiments of the present invention include, but are not limited to, protein crystallization studies, protein solubility studies, determination of properties of fluidics systems, and a variety of biological assays such as diffusive immunoassays, substrate turnover assays, and competitive binding assays.
摘要:
In various embodiments, a pump is provided that includes a microfluidic channel and a plurality of electrodes for electrostatically translating a target fluid along the channel from an inlet to an outlet. In other embodiments, a valve includes a microfluidic channel, a reservoir in fluidic communication with the channel, and an electrode for electrostatically drawing a fluid from the reservoir into the channel so as to block the flow of other fluids through the channel.
摘要:
An embodiment of the invention relates to a fluidic system (200) in which a first channel (210) and a second channel (230) are separated by a fluidic stop (220), for example a region with a hydrophobic coating and/or a structure (220) with non-capillary internal dimensions. Moreover, it comprises a flexible element (240) that is deformable to enable a flow of a medium across the fluidic stop.
摘要:
The invention provides a new microfluidic device and method for performing operations on droplets. The invention extends to microfluidic systems comprising one or more of the microfluidic devices.
摘要:
A series of microactuators for manipulating small quantities of liquids, and methods of using these for manipulating liquids, are disclosed. The microactuators are based on the phenomenon of electrowetting and contain no moving parts. The force acting on the liquid is a potential-dependent gradient of adhesion energy between the liquid and a solid insulating surface.
摘要:
A valve 25 includes: a passage 33 having a first passage 31 which communicates an atmosphere-communicating passage 24 and outside of a cartridge body 10, and a second passage 32 which branches from the first passage; an electrode 35 provided on a wall surface forming the second passage 32; an electrode 37 provided on a wall surface of a bottom wall 11d forming the first passage 31; a driver IC 44 which applies a predetermined voltage selectively to one of these two kinds of electrodes 35, 37; an insulating film 36 provided on a surface of the electrode 35; and an insulating film 38 provided on a surface of the electrode 37. Accordingly, there is provided a valve which is capable of opening and closing a passage communicating two spaces separated from each other, which has no movable part, and which has a simple construction.
摘要:
A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.
摘要:
A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves.