公开(公告)号：US20240166593A1

公开(公告)日：2024-05-23

申请号：US18263795

申请日：2022-02-02

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Srinivas RAMISHETTI ,  Dan PEER

IPC: C07C239/22 ,  A61K9/127 ,  C07C229/12 ,  C07C229/16 ,  C07C233/36 ,  C07D295/15 ,  C12N15/88

CPC classification number: C07C239/22 ,  A61K9/1272 ,  C07C229/12 ,  C07C229/16 ,  C07C233/36 ,  C07D295/15 ,  C12N15/88

Abstract: The present invention provides lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

公开(公告)号：US20240246898A1

公开(公告)日：2024-07-25

申请号：US18489240

申请日：2023-10-18

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan PEER ,  Srinivas RAMISHETTI

IPC: C07C211/22 ,  A61K47/18 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07C59/01 ,  C07C215/08 ,  C07C219/04 ,  C07C229/02 ,  C07C229/10 ,  C07C229/12 ,  C07C233/00 ,  C07C243/00 ,  C07C243/10 ,  C07C243/14 ,  C07C243/16 ,  C07C243/26 ,  C07C243/28 ,  C07C279/04 ,  C07C333/10 ,  C07D233/64 ,  C07D295/13 ,  C07D295/15 ,  C12N15/113

CPC classification number: C07C211/22 ,  A61K47/18 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07C59/01 ,  C07C215/08 ,  C07C219/04 ,  C07C229/02 ,  C07C229/10 ,  C07C229/12 ,  C07C233/00 ,  C07C243/00 ,  C07C243/10 ,  C07C243/14 ,  C07C243/16 ,  C07C243/26 ,  C07C243/28 ,  C07C279/04 ,  C07C333/10 ,  C07D233/64 ,  C07D295/13 ,  C07D295/15 ,  C12N15/113 ,  C12N2310/14

Abstract: The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

公开(公告)号：US20210108228A1

公开(公告)日：2021-04-15

申请号：US17128736

申请日：2020-12-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan PEER ,  Shiri WEINSTEIN ,  Itai Antoine TOKER ,  Srinivas RAMISHETTI

IPC: C12N15/88 ,  A61K39/395 ,  C07K16/28 ,  A61K47/68 ,  A61K31/7105 ,  A61K31/713 ,  A61K31/105 ,  A61K47/69 ,  A61P35/02 ,  A61K9/00 ,  A61K9/51 ,  A61K48/00

Abstract: Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.

公开(公告)号：US20190292130A1

公开(公告)日：2019-09-26

申请号：US16347995

申请日：2017-11-07

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan PEER ,  Srinivas RAMISHETTI

IPC: C07C211/22 ,  C07C243/16 ,  C07C243/00 ,  C07D295/15 ,  C07C229/12 ,  C07C243/28 ,  C07C215/08 ,  A61K47/18 ,  C12N15/113

Abstract: The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.