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    4-hydroxyphenylalkylamine derivative
    3.
    发明授权
    4-hydroxyphenylalkylamine derivative 有权
    4-羟基苯基烷基胺衍生物

    公开(公告)号：US08624064B2

    公开(公告)日：2014-01-07

    申请号：US12808855

    申请日：2008-12-16

    申请人： Takeaki Saiki ,  Keiji Wakita ,  Yasushi Sugiura ,  Yoshinori Taniguchi

    发明人： Takeaki Saiki ,  Keiji Wakita ,  Yasushi Sugiura ,  Yoshinori Taniguchi

    IPC分类号： C07C211/09 ,  C07C211/17 ,  C07C211/18 ,  C07C211/22 ,  C07C211/50 ,  C07C211/53

    CPC分类号： C08F2/40 ,  C07B63/04 ,  C07D295/08 ,  C07D295/096 ,  C07F7/1804 ,  C09K15/24

    摘要： The present invention relates to a compound represented by the following general formula (I): wherein R1 and R2 independently represent a monovalent hydrocarbon group; R3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; X represents a divalent hydrocarbon group; and R4, R5 and R6 independently represent a monovalent organic group or a group represented by the following general formula (II): in which R7 and R8 independently represent a monovalent hydrocarbon group; and R9 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, with the proviso that R5 and R6 may combine together to form a divalent hydrocarbon group. The aforementioned compounds are useful as a polymerization inhibitor and the like.

    摘要翻译： 本发明涉及由以下通式（I）表示的化合物：其中R1和R2独立地表示一价烃基; R3表示氢原子或碳原子数1〜4的烷基。 X表示二价烃基; 并且R 4，R 5和R 6独立地表示一价有机基团或由以下通式（II）表示的基团：其中R 7和R 8独立地表示一价烃基; 并且R 9表示氢原子或具有1至4个碳原子的烷基，条件是R 5和R 6可以结合在一起形成二价烃基。 上述化合物可用作阻聚剂等。

    NOVEL SYNTHESIS OF SUBSTITUTED 4-AMINO-PYRIMIDINES
    4.
    发明申请
    NOVEL SYNTHESIS OF SUBSTITUTED 4-AMINO-PYRIMIDINES 有权
    取代的4-氨基吡啶的新合成

    公开(公告)号：US20110178300A1

    公开(公告)日：2011-07-21

    申请号：US13055579

    申请日：2009-07-22

    申请人： Reinhard Karge ,  Ulla Letinois ,  Gerhard Shiefer

    发明人： Reinhard Karge ,  Ulla Letinois ,  Gerhard Shiefer

    IPC分类号： C07D239/42 ,  C07C211/22

    CPC分类号： C07C255/30 ,  C07C271/20 ,  Y02P20/55

    摘要： The present invention is directed to a process for the manufacture of compounds of formula IV wherein R1 is an amino protecting group, and R2 is hydrogen or C1-10 alkyl, comprising a) reacting a compound of formula Ia, wherein M+ is a cation, preferably selected from the group consisting of Li+, Na+, K+, ms, ½ Mg2+ and ½ Zn2+, (formula 1a) with an ammonium salt NH4X−, wherein X− is an anion, preferably selected from the group consisting of chloride, bromide, sulfate and acetate, in a solvent to a compound of formula II b) reacting a compound of formula II with a nitrile R2—CN in the presence of a base to a compound of formula IV. The present invention is further directed to compounds of formula II and their use for the manufacture of vitamin B1.

    摘要翻译： 本发明涉及制备式IV化合物的方法，其中R 1是氨基保护基，R 2是氢或C 1-10烷基，其包括a）使式Ia化合物（其中M +是阳离子） 优选选自Li +，Na +，K +，ms，½Mg2 +和½Zn2 +，（式1a）与铵盐NH4X-，其中X是阴离子，优选选自氯化物，溴化物， 硫酸盐和乙酸盐，在溶剂中与式Ⅱ化合物反应b）使式Ⅱ化合物与腈R2-CN在碱的存在下反应于式Ⅳ化合物。 本发明还涉及式II化合物及其制备维生素B1的用途。

    NEW TYPE OF PHASE SEPARATION OF MICELLAR COLLOID SOLUTIONS
    5.
    发明申请
    NEW TYPE OF PHASE SEPARATION OF MICELLAR COLLOID SOLUTIONS 审中-公开
    微胶囊溶液的新型相分离方法

    公开(公告)号：US20080084000A1

    公开(公告)日：2008-04-10

    申请号：US11870937

    申请日：2007-10-11

    申请人： TIBOR FORSTER

    发明人： TIBOR FORSTER

    IPC分类号： B01J13/20 ,  C07C211/13 ,  C07C211/22 ,  C07H21/00 ,  C07K14/00

    CPC分类号： A61K9/1075 ,  B01J13/00 ,  B01J13/02

    摘要： The invention provides colloid systems, preferably capsules, dispersions and emulsions, assembled by micelles containing new-type anionic surfactant and small molecular cationic complexing agent. Furthermore, the invention provides a method for phase separation, preferably for coacervation, of polymolecular colloid systems composed of aqueous anionic surfactants and the associates of them be the use of non colloidal sized complexing agents (polymolecular complex coacervation), and the use of this method for separating biologically active substances and for producing capsules, dispersions and emulsions containing such substances. Additionally, the invention provides reagent kits for performing the method of the invention. The colloid systems and methods of the invention can be very widely used for isolating, stabilizing or removing different substances, such as proteins, lipids, stains or dyes, radioactive substances, for isolating nucleic acids and for encapsulating or emulgeating different substances, such as proteins, active ingredients, stains or dyes, etc.

    摘要翻译： 本发明提供胶体体系，优选胶囊，分散体和乳液，由含有新型阴离子表面活性剂和小分子阳离子络合剂的胶束组装。 此外，本发明提供了一种用于相分离，优选用于凝聚由含水阴离子表面活性剂组成的多分子胶体体系的方法，并且它们的缔合体是使用非胶体大小的络合剂（多分子复合物凝聚），并且使用该方法 用于分离生物活性物质和用于生产含有这些物质的胶囊，分散体和乳液。 另外，本发明提供了用于执行本发明方法的试剂盒。 本发明的胶体体系和方法可以被广泛地用于分离，稳定或除去不同物质，如蛋白质，脂质，污渍或染料，放射性物质，用于分离核酸，以及包封或浸润不同物质如蛋白质 ，活性成分，污渍或染料等

    Process for the manufacture of a bitumen-aggregate mix suitable for road pavement
    6.
    发明授权
    Process for the manufacture of a bitumen-aggregate mix suitable for road pavement 有权
    制造沥青混合料的方法，适用于道路路面

    公开(公告)号：US07226501B2

    公开(公告)日：2007-06-05

    申请号：US10567277

    申请日：2004-06-23

    申请人： Bengt-Arne Thorstensson ,  Keith Shaw ,  Thomas Wallin ,  Leif-Göran Ståhlgren

    发明人： Bengt-Arne Thorstensson ,  Keith Shaw ,  Thomas Wallin ,  Leif-Göran Ståhlgren

    IPC分类号： B01F17/14 ,  C07C211/63 ,  C07C211/22 ,  C08L95/00 ,  C09D195/00

    CPC分类号： C08K5/5205 ,  C08L95/005 ,  Y10S516/907 ,  Y10S516/908 ,  C08L95/00 ,  C08L2666/74

    摘要： The present invention relates to an aqueous quick-setting bitumen-aggregate mix suitable for cold pavement of roads, parking places, sidewalks and the like. The bitumen-aggregate mix is manufactured by mixing a mineral aggregate, water, a de-emulsifier, containing hydraulic cement, and a cationic oil-in-water bitumen emulsion, containing, as an emulsifier, a salt of a tertiary diamine and a phosphoric acid. The diamine has the formula (I), where one or two of the groups R1, R2, R4 and R5 designate a hydrocarbon group of 6–22, preferably 8–20 carbon atoms, and the remaining R1, R2, R4 and R5 groups are an alkyl group with 1–4 carbon atoms, and/or a group —(A)2H, where A is an alkyleneoxy group with 2–3 carbon atoms, and s is a number from 1–4, R3 is an alkylene group with 2–4 carbon atoms and n is a number from 0–2.

    摘要翻译： 本发明涉及一种适用于道路，停车位，人行道等的冷路面的水性快速凝固沥青骨料混合物。 沥青骨料混合物通过混合矿物骨料，水，含水硬性水泥的去乳化剂和阳离子水包油沥青乳液制成，所述乳化剂含有作为乳化剂的叔胺和磷酸盐 酸。 二胺具有式（I），其中R 1，R 2，R 4和R 3中的一个或两个 5个碳原子表示6-22个碳原子，优选8-20个碳原子的烃基，剩余的R 1，R 2，R 4， R 3和R 5基团是具有1-4个碳原子的烷基和/或基团 - （A）2 H，其中A是亚烷基氧基 具有2-3个碳原子，s是1-4的数，R 3是具有2-4个碳原子的亚烷基，n是0-2的数。