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    Lipid-based nitric oxide donors
    2.
    发明授权
    Lipid-based nitric oxide donors 有权
    基于脂质的一氧化氮供体

    公开(公告)号：US07696247B2

    公开(公告)日：2010-04-13

    申请号：US10885055

    申请日：2004-07-06

    申请人： Robert A. Herrmann ,  Wendy Naimark

    发明人： Robert A. Herrmann ,  Wendy Naimark

    IPC分类号： A61K31/20 ,  A01N33/26 ,  C07C205/00 ,  C07C207/00 ,  C07C241/00 ,  C07C243/00

    CPC分类号： A61L29/16 ,  A61K45/06 ,  A61L15/44 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/416 ,  C07C243/42 ,  C07J41/0055 ,  Y10T436/104165

    摘要： Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, and (f) sterol compounds of the formula: where R is a branched aliphatic chain of eight or more carbon atoms, wherein the lipid molecule is provided with a nitric-oxide containing group which comprises (a) a —S—N═O moiety, (b) a —O—N═O moiety, or (c) a a moiety. Also provided are methods of forming such nitric oxide releasing lipid molecules. Various pharmaceutical compositions, topical liquids and drug delivery systems comprising the nitric-oxide releasing lipid molecules are also described. Further provided are methods for therapeutically administering nitric oxide to patients, methods of treating or preventing various conditions, methods for promoting wound healing and methods of reducing the cells present in an atherosclerotic lesion, which methods utilize the nitric-oxide releasing lipid molecules.

    摘要翻译： 提供新的一氧化氮释放脂质分子，其包含选自（a）磷酸甘油酯，（b）具有鞘氨醇碱作为主链的脂质的脂质分子，（c）单酰基甘醇，（d）二酰基甘油，（e）糖基酰基甘油和（ f）下式的甾醇化合物：其中R是具有8个或更多个碳原子的支链脂族链，其中所述脂质分子具有含一氧化氮的基团，其包含（a）-S-N = O部分，（ b）-O-N = O部分，或（c）aa部分。 还提供了形成这种一氧化氮释放脂质分子的方法。 还描述了包含释放一氧化氮的脂质分子的各种药物组合物，局部液体和药物递送系统。 还提供了向患者治疗性给予一氧化氮的方法，治疗或预防各种病症的方法，促进伤口愈合的方法以及减少存在于动脉粥样硬化病变中的细胞的方法，该方法利用释放一氧化氮的脂质分子。

    Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists
    10.
    发明授权
    Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists 有权
    环戊胺和环己胺衍生物作为NK-1 / SSRI拮抗剂

    公开(公告)号：US07276631B2

    公开(公告)日：2007-10-02

    申请号：US11183700

    申请日：2005-07-18

    申请人： Yong-Jin Wu ,  Huan He

    发明人： Yong-Jin Wu ,  Huan He

    IPC分类号： C07C243/00 ,  A01N31/00

    CPC分类号： C07C217/52 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14

    摘要： The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compounds are useful for the useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.

    摘要翻译： 本公开涉及化学化合物及其在人类治疗中的用途。 本公开的具体实施方案涉及式（I）的化合物; 或其异构体，药学上可接受的盐或溶剂合物或包含所述化合物的药学上可接受的制剂可用于治疗或预防由速激肽介导的病症和/或选择性抑制5-羟色胺再摄取转运蛋白。 该化合物作为双重NK-1拮抗剂和选择性5-羟色胺再摄取抑制剂。