公开(公告)号：US3870710A

公开(公告)日：1975-03-11

申请号：US33041173

申请日：1973-02-07

Applicant: ROUSSEL UCLAF

Inventor： MARTEL JACQUES ,  TOROMANOFF EDMOND ,  BUENDIA JEAN

IPC: C07C59/90 ,  C07C405/00 ,  C07D303/42 ,  C07D309/12 ,  C07C69/74 ,  C07D7/04

CPC classification number: C07C59/90 ,  C07C405/00 ,  C07D303/42 ,  C07D309/12 ,  Y10S514/866

Abstract: WHEREIN R is selected from the group consisting of hydrogen and alkyl of 1 to 7 carbon atoms, R1 is selected from the group consisting of hydrogen and carbalkoxy of 1 to 7 alkyl carbon atoms, R2 is selected from the group consisting of hydrogen, carboxy and carbalkoxy of 1 to 7 alkyl carbon atoms, R3 is selected from the group consisting of hydrogen and Alpha tetrahydropyranyl, m is 3,4 or 5 and n is 2,3 or 4 with the proviso that when R1 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R2 is hydrogen and R3 is Alpha -tetrahydro pyranyl; when R2 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R1 is hydrogen and R3 is Alpha -tetrahydropyranyl and when R2 is carboxy, R and R1 are hydrogen and R3 is Alpha tetrahydropyranyl, which possess the physiological activity of prostaglandins, and salts thereof when R, R1, R2 and R3 are hydrogen, with non-toxic, pharmaceutically acceptable bases and their preparation.

Novel prostanoic acid derivatives of the formula

Abstract translation: 式WHEREIN R的新型前列腺烷酸衍生物选自氢和1至7个碳原子的烷基，R 1选自氢和1至7个烷基碳原子的烷氧基，R2选自 由1至7个碳原子的氢，羧基和烷氧基组成的基团，R 3选自氢和α-四氢吡喃基，m为3,4或5，n为2,3或4，条件是当 R1是烷氧基，R是1至7个碳原子的烷基，R2是氢，R3是α-四氢吡喃基; 当R 2为烷氧基时，R为1至7个碳原子的烷基，R 1为氢，R 3为α-四氢吡喃基，当R 2为羧基时，R 1和R 1为氢，R 3为具有前列腺素生理活性的α-四氢吡喃基， 当R，R 1，R 2和R 3为氢时，其盐为无毒，药学上可接受的碱及其制备。

公开(公告)号：US3538144A

公开(公告)日：1970-11-03

申请号：US3538144D

申请日：1967-10-16

Applicant: ROUSSEL UCLAF

Inventor： MARTEL JACQUES ,  TOROMANOFF EDMOND ,  HUYNH CHANH

IPC: C07C69/757 ,  C07C255/45 ,  C07C255/53 ,  C07C69/76

CPC classification number: C07C255/45 ,  C07C69/757 ,  C07C255/53

公开(公告)号：US3868402A

公开(公告)日：1975-02-25

申请号：US30679672

申请日：1972-11-15

Applicant: ROUSSEL UCLAF

Inventor： MARTEL JACQUES ,  TOROMANOFF EDMOND

IPC: C07C405/00 ,  C07D309/12 ,  C07C69/74

CPC classification number: C07D309/12 ,  C07C405/00

Abstract: Novel alkyl 3-(3''-OR-trans 1''-alkenyl)-cyclopentanone-2carboxylates of the formula

WHEREIN Alk is alkyl of 1 to 7 carbon atoms, R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 18 carbon atoms and Alpha -tetrahydropyranyl and m is 3, 4 or 5 which are intermediates for prostaglandins and their preparation and novel intermediates.

Abstract translation: 新的式（III-OR-反式1'-链烯基） - 环戊酮-2-羧酸烷基酯式为WHEREIN Alk是1至7个碳原子的烷基，R选自氢，有机 1至18个碳原子的羧酸和α-四氢吡喃基，m是3,4或5，它们是前列腺素的中间体及其制备和新型中间体。

公开(公告)号：US3865854A

公开(公告)日：1975-02-11

申请号：US28643972

申请日：1972-09-05

Applicant: ROUSSEL UCLAF

Inventor： HAINAUT DANIEL ,  TOROMANOFF EDMOND ,  DEMOUTE JEAN-PIERRE

IPC: C07C69/587 ,  C07C20060101 ,  C07C67/00 ,  C07C67/30 ,  C07C69/00 ,  C07C69/52 ,  C07D20060101 ,  C07D335/02 ,  C07C65/08

CPC classification number: C07C51/097 ,  Y10S424/12

Abstract: A process for the production of alkyl 3,11-dimethyl-7-ethyl2,6,10-tridecatrienoates starting from the S-oxide of 4-methyl5,6-dihydro-2H-thiapyran, 1-oxa-6-thia-spiro/2,5/octane and alkyl 3-methyl-4-halo-2-butenoate and the novel intermediates. The alkyl 3,11-dimethyl-7-ethyl-2,6,10-tridecatrienoates are intermediates in the synthesis of the juvenile hormone.

Abstract translation: 一种从4-甲基-5,6-二氢-2H-噻唑烷的1-氧化物，1-氧杂-6-S的氧化物制备3,11-二甲基-7-乙基-2,6,10-十三碳三烯酸烷基酯的方法 噻吩/ 2,5 /辛烷和3-甲基-4-卤代-2-丁烯酸烷基酯和新的中间体。 3,11-二甲基-7-乙基-2,6,10-十三碳三烯酸烷基酯是少年激素合成中的中间体。

公开(公告)号：US3870711A

公开(公告)日：1975-03-11

申请号：US40070973

申请日：1973-09-26

Applicant: ROUSSEL UCLAF

Inventor： MARTEL JACQUES ,  BUENDIA JEAN ,  TOROMANOFF EDMOND

IPC: C07C405/00 ,  C07D303/42 ,  C07D309/12 ,  C07D521/00 ,  C07D7/02

CPC classification number: C07D231/12 ,  C07C405/00 ,  C07D233/56 ,  C07D249/08 ,  C07D303/42 ,  C07D309/12

Abstract: Novel intermediates formed in the process for the preparation of derivatives of prostanoic acids of the prostaglandin A2 (PGA2) group of the formula

WHEREIN R is selected from the group consisting of hydrogen and lower alkyl, n is a whole number of 2,3 or 4 and m is a whole number of 3,4 or 5 and to novel intermediates produced in the said process.

Abstract translation: 在制备式WHEREIN R的前列腺素A2（PGA2）基的前列腺酸衍生物的方法中形成的新型中间体选自氢和低级烷基，n是整数2,3或4 并且m是3,4或5的整数，并且在所述方法中产生的新的中间体。

公开(公告)号：US3445499A

公开(公告)日：1969-05-20

申请号：US3445499D

申请日：1965-05-10

Applicant: ROUSSEL UCLAF

Inventor： MARTEL JACQUES ,  HUYNH CHANH ,  TOROMANOFF EDMOND ,  NOMINE GERARD

IPC: C07C317/04 ,  C07C317/22 ,  C07C147/08 ,  C07C51/09 ,  C07C147/06

CPC classification number: C07C317/22 ,  C07C317/04