公开(公告)号：US20200277406A1

公开(公告)日：2020-09-03

申请号：US16821537

申请日：2020-03-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

IPC: C07K19/00 ,  C07K16/32 ,  C07K16/18 ,  C07K16/28

Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

公开(公告)号：US20160194410A1

公开(公告)日：2016-07-07

申请号：US15079897

申请日：2016-03-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

IPC: C07K19/00

CPC classification number: C07K19/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/626 ,  C07K2317/92 ,  C07K2317/94

Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

Abstract translation: 式Aa'的结合剂：aSb：b'-B：X（n），其中A和B是一价结合剂，a：a以及b：b'是一个结合对，其中a' 并且a不干扰b与b'的结合，反之亦然，S是长度至少为1nm的间隔物：X表示共价或通过结合对结合至至少一个“ ，a，b，b'或S，（n）为整数且至少为1， - 表示共价键，连接体aSb的长度为6〜100nm。 还公开了生产这种结合剂及其某些用途的方法。

公开(公告)号：US20150355199A1

公开(公告)日：2015-12-10

申请号：US14835821

申请日：2015-08-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Alfred Engel ,  Andreas Gallusser ,  Johann Karl ,  Peter Kastner ,  Wolfgang Obermeier ,  Monika Soukupova

IPC: G01N33/68 ,  C07K16/18 ,  G01N33/543

CPC classification number: C07K16/18 ,  C07K14/472 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/54306 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/30 ,  G01N2800/52

Abstract: The present invention relates to an assay for specific detection of complement factor H-related protein 1 (CFHR1) in a sample from a subject, as well as kits and agents related thereto.

Abstract translation: 本发明涉及用于特异性检测来自受试者的样品中的补体因子H相关蛋白1（CFHR1）的测定，以及与其相关的试剂盒和试剂。

公开(公告)号：US20130289251A1

公开(公告)日：2013-10-31

申请号：US13923631

申请日：2013-06-21

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

IPC: C07K19/00

CPC classification number: C07K19/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/626 ,  C07K2317/92 ,  C07K2317/94

Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, - represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

Abstract translation: 式A-a'：aSb：b'-B：X（n）的结合剂，其中A以及B是单价键合物，a：a以及b：b'是结合对，其中 a'和a不干扰b与b'的结合，反之亦然，S是长度至少为1nm的间隔物：X表示与共价键或通过结合对键合到至少一个 a'，a，b，b'或S，（n）为整数且至少为1， - 表示共价键，连接体aSb的长度为6〜100nm。 还公开了生产这种结合剂及其某些用途的方法。