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    BINDING AGENT
    2.
    发明申请
    BINDING AGENT 审中-公开
    绑定代理

    公开(公告)号：US20130289251A1

    公开(公告)日：2013-10-31

    申请号：US13923631

    申请日：2013-06-21

    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00

    CPC classification number: C07K19/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/626 ,  C07K2317/92 ,  C07K2317/94

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, - represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    Abstract translation: 式A-a'：aSb：b'-B：X（n）的结合剂，其中A以及B是单价键合物，a：a以及b：b'是结合对，其中 a'和a不干扰b与b'的结合，反之亦然，S是长度至少为1nm的间隔物：X表示与共价键或通过结合对键合到至少一个 a'，a，b，b'或S，（n）为整数且至少为1， - 表示共价键，连接体aSb的长度为6〜100nm。 还公开了生产这种结合剂及其某些用途的方法。

    BINDING AGENT
    3.
    发明申请
    BINDING AGENT 审中-公开

    公开(公告)号：US20200277406A1

    公开(公告)日：2020-09-03

    申请号：US16821537

    申请日：2020-03-17

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00 ,  C07K16/32 ,  C07K16/18 ,  C07K16/28

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    BINDING AGENT
    4.
    发明申请
    BINDING AGENT 审中-公开
    绑定代理

    公开(公告)号：US20160194410A1

    公开(公告)日：2016-07-07

    申请号：US15079897

    申请日：2016-03-24

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00

    CPC classification number: C07K19/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/626 ,  C07K2317/92 ,  C07K2317/94

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    Abstract translation: 式Aa'的结合剂：aSb：b'-B：X（n），其中A和B是一价结合剂，a：a以及b：b'是一个结合对，其中a' 并且a不干扰b与b'的结合，反之亦然，S是长度至少为1nm的间隔物：X表示共价或通过结合对结合至至少一个“ ，a，b，b'或S，（n）为整数且至少为1， - 表示共价键，连接体aSb的长度为6〜100nm。 还公开了生产这种结合剂及其某些用途的方法。

    Reagents for Lysis of Bacterial Cells
    8.
    发明申请
    Reagents for Lysis of Bacterial Cells 审中-公开
    细菌细胞裂解试剂

    公开(公告)号：US20160264925A1

    公开(公告)日：2016-09-15

    申请号：US15161358

    申请日：2016-05-23

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christian Birkner ,  Herbert von der Eltz ,  Monika Soukopova

    IPC: C12N1/06 ,  C12N1/20

    CPC classification number: C12N1/06 ,  C12N1/20

    Abstract: The invention provides a composition containing an aqueous liquid phase, bacterial cells, and an ionic compound dissolved in the liquid phase. The ionic compound is selected from the group consisting of 1-butyl-3-methyl-imidazolium-thiocyanate, 1-butyl-3-methyl-imidazolium-2(2-methoxy-ethoxy)ethylsulfate, 1-methyl-1-[4-(3-methyl-3H-imidazol-1-ium)-but-1-yl]-3H-imidazolium-di(toluylsulfate), and 1-butyl-3-methyl-imidazolium-octylsulfate. The compositions of the invention are advantageously used for preparing lysates of biological cells, particularly bacterial cells.

    Abstract translation: 本发明提供一种含有水相液相，细菌细胞和溶于液相的离子化合物的组合物。 离子化合物选自1-丁基-3-甲基 - 咪唑鎓 - 硫氰酸酯，1-丁基-3-甲基 - 咪唑鎓-2（2-甲氧基 - 乙氧基）乙基硫酸酯，1-甲基-1- [4 - （3-甲基-3H-咪唑-1-基） - 丁-1-基] -3H-咪唑鎓 - 二（甲苯基硫酸盐）和1-丁基-3-甲基 - 咪唑鎓辛基硫酸盐。 本发明的组合物有利地用于制备生物细胞，特别是细菌细胞的裂解物。

    SET OF OLIGONUCLEOTIDE PROBES AS WELL AS METHODS AND USES THERETO
    9.
    发明申请
    SET OF OLIGONUCLEOTIDE PROBES AS WELL AS METHODS AND USES THERETO 有权
    作为方法和用途的一组寡核苷酸探针

    公开(公告)号：US20130203628A1

    公开(公告)日：2013-08-08

    申请号：US13862530

    申请日：2013-04-15

    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

    Inventor： Frank Bergmann ,  Walter Eberle ,  Thomas Fischer ,  Herbert von der Eltz

    IPC: C12Q1/68

    CPC classification number: C12Q1/6841 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2565/1025 ,  C12Q2563/107

    Abstract: The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes. Further, the present disclosure relates to a kit comprising the set of oligonucleotide probes and at least one further component.

    Abstract translation: 本公开内容涉及针对感兴趣的基因组靶序列的（或互补）部分的一组至少100个单链寡核苷酸探针。 本公开还涉及使用该组寡核苷酸探针检测感兴趣的基因组靶序列的方法和产生寡核苷酸探针组的方法。 此外，本公开涉及包含该组寡核苷酸探针和至少一种另外的组分的试剂盒。

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