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公开(公告)号：US20210061924A1
公开(公告)日：2021-03-04
申请号：US17069349
申请日：2020-10-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hartmut Duefel , Alfred Engel , Frank Kroner , Thomas Meier , Sandra Rutz , Michael Schraeml , Gloria Tabares , Ulrike Kurtkaya , Boris Pinchuk , Christina Zimmermann
IPC: C07K16/40 , G01N33/543
Abstract: The present invention relates to a novel monoclonal antibody that specifically binds to a conformation dependent epitope on human thymidine kinase 1 (hTK-1; SEQ ID NO:1), to methods for quantifying hTK-1 employing the antibody and to the use of the anti-hTK-1 antibody in quantifying hTK-1.
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公开(公告)号：US20210009668A1
公开(公告)日：2021-01-14
申请号：US17015662
申请日：2020-09-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Kroner , Michael Schraeml , Sarah Liedke
Abstract: The present invention relates to improved variant monoclonal antibodies binding to cardiac troponin T and having a better KD than the monoclonal antibody 12.1A11.11-7, produced by hybridoma clone 7.1 A 12.2-22 (ECACC 89060901) as deposited with European Collection of Animal Cell Cultures, GB. 5
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公开(公告)号：US20250043024A1
公开(公告)日：2025-02-06
申请号：US18772484
申请日：2024-07-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hartmut Duefel , Alfred Engel , Frank Kroner , Thomas Meier , Sandra Rutz , Michael Schraeml , Gloria Tabares , Ulrike Kurtkaya , Boris Pinchuk , Christina Zimmermann
IPC: C07K16/40 , G01N33/543
Abstract: The present invention relates to a novel monoclonal antibody that specifically binds to a conformation dependent epitope on human thymidine kinase 1 (hTK-1; SEQ ID NO:1), to methods for quantifying hTK-1 employing the antibody and to the use of the anti-hTK-1 antibody in quantifying hTK-1
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Patent Agency Ranking
公开(公告)号：US12077600B2
公开(公告)日：2024-09-03
申请号：US17069349
申请日：2020-10-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hartmut Duefel , Alfred Engel , Frank Kroner , Thomas Meier , Sandra Rutz , Michael Schraeml , Gloria Tabares , Ulrike Kurtkaya , Boris Pinchuk , Christina Zimmermann
IPC: G01N31/00 , C07K16/40 , G01N33/53 , G01N33/543
CPC classification number: C07K16/40 , G01N33/54326 , C07K2317/92
Abstract: The present invention relates to a novel monoclonal antibody that specifically binds to a conformation dependent epitope on human thymidine kinase 1 (hTK-1; SEQ ID NO:1), to methods for quantifying hTK-1 employing the antibody and to the use of the anti-hTK-1 antibody in quantifying hTK-1.
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公开(公告)号：US20210009993A1
公开(公告)日：2021-01-14
申请号：US17015719
申请日：2020-09-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Kroner , Michael Schraeml , Sarah Liedke
Abstract: The present invention relates to a novel method of generating libraries of polynucleotides encoding a framework region and at least one adjacent complementarity determining region (CDR) of an antibody of interest. These libraries are suitable for use in affinity maturation procedures in order to obtain maturated antibodies with improved characteristics compared to the parent antibody.
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公开(公告)号：US20190292535A1
公开(公告)日：2019-09-26
申请号：US16074128
申请日：2012-11-08
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventor： David Casagolda Vallribera , Frank Kroner , Michael Schraeml
Abstract: The present disclosure is directed to a library of chimeric polypeptides comprising one or more fragments from the peptidyl-prolyl cis/trans isomerase or FKBP family displaying one or more polypeptides on one or more FKBP members and its use in methods for the screening and selection of constrained peptide surrogates exhibiting binding activity versus predetermined target molecules.
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公开(公告)号：US10414818B2
公开(公告)日：2019-09-17
申请号：US15025230
申请日：2014-09-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Schraeml , David Casagolda Vallribera , Frank Kroner
IPC: C07K16/12 , G01N33/577
Abstract: The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.
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8.发明申请THERMUS THERMOPHILUS SLYD FKBP DOMAIN SPECIFIC ANTIBODIES 审中-公开THERMUS THERMOPHILUS SLYD FKBP域特异性抗体公开(公告)号：US20160237144A1
公开(公告)日：2016-08-18
申请号：US15025230
申请日：2014-09-22
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventor： Michael Schraeml , David Casagolda Vallribera , Frank Kroner
IPC: C07K16/12 , G01N33/577
CPC classification number: C07K16/1203 , C07K2317/34 , C07K2317/56 , C07K2317/92 , G01N33/577
Abstract: The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.
Abstract translation: 本说明书涉及抗栖热菌嗜热链球菌SlyD FKBP结构域抗体及其使用方法。
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