公开(公告)号：US11747244B2

公开(公告)日：2023-09-05

申请号：US16385712

申请日：2019-04-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Glauser ,  Dietmar Kappelhoff ,  Youssef Khayali

IPC: G01N1/34 ,  B01L3/00 ,  G01N1/40 ,  G01N35/00

CPC classification number: G01N1/34 ,  B01L3/502 ,  G01N1/405 ,  G01N1/4055 ,  G01N1/4077 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/143 ,  B01L2300/069 ,  B01L2300/0681 ,  G01N2001/4088 ,  G01N2035/00019 ,  G01N2035/00465 ,  G01N2035/00475

Abstract: A laboratory system and a method for separating interfering substances contained in test samples is presented. The laboratory system comprises separation vessels comprising solid surfaces and capturing molecules which are immobilized on the solid surfaces. The capturing molecules of the separation vessels are configured to bind interfering substances of laboratory tests of different analytical methods.

公开(公告)号：US20230160915A1

公开(公告)日：2023-05-25

申请号：US18149810

申请日：2023-01-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Glauser ,  Urs Vollenweider

IPC: G01N35/00 ,  G01N35/04

CPC classification number: G01N35/00712 ,  G01N35/04 ,  G01N2035/0401

Abstract: A computer implemented method to allocate control samples for validating a diagnostic test within a laboratory system is provided. The laboratory system comprises a storage, a transport system, and at least two analyzers. A total number of control sample aliquots and an aliquot volume for each control sample aliquot is determined based on a validation time schedule. Information is presented for distributing the total control sample volume into the determined total number of control sample aliquots with the determined aliquot volumes. Information is also presented for distributing the control sample aliquots to one or more of the at least two analyzers according to the validation time schedule.

公开(公告)号：US11579156B2

公开(公告)日：2023-02-14

申请号：US16897591

申请日：2020-06-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Glauser ,  Urs Vollenweider

IPC: G01N35/00 ,  G01N35/04

Abstract: A method to provide control samples for validating a diagnostic test within a laboratory system is presented. The laboratory system comprises an aliquoting device, a storage, a transport system, at least two analyzers, and a control unit. A total number of control sample aliquots and an aliquot volume for each control sample aliquot is determined based on a validation time schedule. A provided total control sample volume is aliquoted into the determined total number of control sample aliquots with the determined aliquot volumes. The generated control sample aliquots are transported to one or more of the at least two analyzers according to the validation time schedule.

公开(公告)号：US09606140B2

公开(公告)日：2017-03-28

申请号：US14286194

申请日：2014-05-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Geza Burghardt ,  Michael Glauser ,  Oliver Gutmann ,  Daniel Mueller ,  Edwin Oosterbroek ,  Roger Sandoz ,  Emad Sarofim ,  Goran Savatic

IPC: G01N21/75 ,  G01P15/02 ,  B01L3/00

CPC classification number: G01P15/02 ,  B01L3/5021 ,  B01L3/5453 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2400/0409

Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

公开(公告)号：US20240371479A1

公开(公告)日：2024-11-07

申请号：US18636375

申请日：2024-04-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Glauser ,  Oliver Gutmann ,  Gabriele Piero Janner ,  Emad Sarofim ,  Stephan Schweighauser ,  Marcel Thomann ,  Urs Vollenweider

IPC: G16H10/40

Abstract: A computer-implemented method for optimising an assignment of one or more medical samples to one or more analytical tests to be conducted on those medical samples. The method comprises the steps of: obtaining an initial assignment of the one or more medical samples to the one or more analytical tests; determining a compliance status for the or each medical sample, the compliance status indicating: (i) whether a sample quality metric of the or each medical sample violates an analytical test specification of the medical sample's assigned analytical test(s) in the initial assignment and/or (ii) whether the or each medical sample is unprocessable; and performing a mitigation action if one or more compliance status indicate: (i) that the sample quality metric of a given medical sample violates the analytical test specification and/or (ii) a given medical sample is unprocessable.