公开(公告)号：US20240329074A1

公开(公告)日：2024-10-03

申请号：US18601690

申请日：2024-03-11

申请人： Ventana Medical Systems, Inc.

发明人： Aaron Ewoniuk ,  Dylan Miller ,  Kevin Talucci

IPC分类号： G01N35/10 ,  B01L3/02 ,  G01F15/075 ,  G01F22/00 ,  G01N1/31 ,  G01N15/10 ,  G01N15/14 ,  G01N35/00

CPC分类号： G01N35/1016 ,  B01L3/0241 ,  G01F15/075 ,  G01F22/00 ,  G01N1/312 ,  G01N15/1459 ,  G01N35/00663 ,  G01N35/00722 ,  G01N35/1002 ,  B01L2200/061 ,  B01L2200/14 ,  B01L2200/143 ,  G01N2015/1027 ,  G01N2015/1493 ,  G01N2035/00673 ,  G01N2035/009

摘要： A system and method for dispense characterization is disclosed. According to particular embodiments of the dispense characterization system and method, volumes of dispensed liquids can be determined. In more particular embodiments, additional characteristics, and combinations of characteristics of a liquid dispensing event can be determined. Examples of additional characteristics that can be determined include the shape of the dispensing event, the velocity of the dispensing event, and the trajectory of the dispensing event. The dispense characterization system and method can be employed in automated biological sample analysis systems, and are particularly suited for monitoring liquid reagent dispensing events that deliver liquid reagents to a surface of a microscope slide holding a biological sample.

公开(公告)号：US20240290598A1

公开(公告)日：2024-08-29

申请号：US18657016

申请日：2024-05-07

申请人： Labcyte Inc.

发明人： Richard G. Stearns

IPC分类号： H01J49/04 ,  B01L3/00

CPC分类号： H01J49/0445 ,  B01L3/502 ,  B01L2200/06 ,  B01L2200/14 ,  B01L2400/0436

摘要： Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. In one embodiment, a first toneburst is applied to temporarily raise a mound or protuberance on a free surface of the fluid. After the mound has reached a certain state, at least two additional toneburst can be applied to the protuberance to sequentially eject multiple bursts of multiple droplets. In one embodiment, the state of the mound can be maintained by a sustained acoustic signal, during which time multiple additional tonebursts can be applied to sequentially eject multiple bursts of multiple droplets from the mound.

公开(公告)号：US12061193B2

公开(公告)日：2024-08-13

申请号：US17336858

申请日：2021-06-02

申请人： Purdue Research Foundation

发明人： Jacqueline Callihan Linnes ,  Laura Mae Jamicich ,  Elizabeth A. Phillips ,  Kristin M. Byers ,  Anna Bird

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54306 ,  B01L3/5023 ,  B01L3/527 ,  G01N33/54388 ,  G01N33/54393 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0406

摘要： This invention relates to an improved version of paper-based analytical device and method for chromatographic chemical or immunoassays. Particularly, this present invention discloses a device and a method for reducing smears and improving sharpness and intensity of test sample readout for a multi-step chemical assay or immunoassay by introducing two additional elements, a time-delay pad (2) and a mixer (1), to the conventional two-dimensional paper network device (2DPN).

公开(公告)号：US20240264183A1

公开(公告)日：2024-08-08

申请号：US18640413

申请日：2024-04-19

申请人： Beckman Coulter, Inc.

发明人： Wido MENHARDT ,  Matthew HANSON ,  Anthony CAMISA

IPC分类号： G01N35/00 ,  B01L9/06 ,  G16H10/40

CPC分类号： G01N35/00613 ,  B01L9/06 ,  G01N35/00712 ,  G01N35/00871 ,  G16H10/40 ,  B01L2200/14 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2200/185 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0663 ,  G01N2035/00752 ,  G01N2035/00851

摘要： A method of reducing quality problems associated with patient sample collection and delivery is provided. It is possible that the method can provide a chain of custody process to better track a sample from the initial point of sample collection to the final point of sample testing. Such a method can also include providing an alert to indicate a potential problem with the quality of the diagnostic test result when a measured parameter exceeds a threshold.

公开(公告)号：US12053780B2

公开(公告)日：2024-08-06

申请号：US17470615

申请日：2021-09-09

申请人： CUE HEALTH INC.

发明人： Ayub Khattak ,  Clinton Sever ,  Paul Nelson ,  Ryan Cooper ,  Thomas Congdon ,  Justin Demartino ,  Raphael Shapiro ,  Mark Duncan

IPC分类号： B01L3/00 ,  A61B10/00 ,  A61B10/02 ,  B65D83/00 ,  B65D83/04 ,  B65D83/08 ,  G01N27/327 ,  G01N33/543 ,  G01N35/00 ,  G01N35/10 ,  A61B5/157 ,  C12Q1/6825

CPC分类号： B01L3/508 ,  A61B10/0045 ,  A61B10/02 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/5029 ,  B01L3/523 ,  B65D83/005 ,  B65D83/04 ,  B65D83/0817 ,  B65D83/0858 ,  G01N27/3273 ,  G01N33/54366 ,  G01N35/0098 ,  G01N35/10 ,  A61B5/157 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/047 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  C12Q1/6825

摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US20230302442A1

公开(公告)日：2023-09-28

申请号：US18090579

申请日：2022-12-29

申请人： TECAN TRADING AG

发明人： Adrian SAGER

IPC分类号： B01L3/02

CPC分类号： B01L3/0275 ,  B01L2300/123 ,  B01L2200/026 ,  B01L2200/04 ,  B01L2300/06 ,  B01L2200/14 ,  B01L2200/12 ,  B01L2200/021

摘要： A pipette tip extension attachable to a pipette tip with the pipette tip extension having a proximal end, a distal end, and exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall having an outer side and inner side and forming at the proximal end a reception aperture for inserting a pipette tip, and at a distal end a dispense aperture. An inner cavity is enclosed by the inner side of the exterior wall and one or more distance elements connected to the inner side of the exterior wall. The distance element(s) being configured to position a pipette tip within the inner cavity and to establish fluid uptake area adjacent the inner side of the exterior wall with the fluid uptake area extending from the dispense aperture towards the reception aperture and being in fluid connection with the surrounding atmosphere at the reception aperture.

公开(公告)号：US20230285971A1

公开(公告)日：2023-09-14

申请号：US17734050

申请日：2022-04-30

申请人： Thunderbio innovation Ltd.

发明人： Hongbo ZHOU ,  Ruyuan SONG ,  Xiaonan XU

IPC分类号： B01L3/00

CPC分类号： B01L3/502761 ,  B01L2200/14 ,  B01L2200/0652 ,  B01L2300/08 ,  B01L2300/0832 ,  B01L2200/027

摘要： The present invention relates to the field of droplet microfluidics, particularly relates to a droplet sorting chip. The droplet sorting chip disclosed herein is provided with a cavity area, which can accommodate impurities such as fibers entering the droplet sorting chip, can effectively prevent clogging and collision and fusion of droplets caused by impurities, and ensure smooth droplet sorting.

公开(公告)号：US20230271175A1

公开(公告)日：2023-08-31

申请号：US18174710

申请日：2023-02-27

申请人： SYSMEX CORPORATION

发明人： Yuto SASAKI ,  Keiichiro SHOHMI ,  Kazuyuki IGUCHI

IPC分类号： B01L3/00

CPC分类号： B01L3/5021 ,  B01L3/50825 ,  B01L2200/025 ,  B01L2200/14 ,  B01L2300/042 ,  B01L2300/0609 ,  B01L2300/0848

摘要： A specimen preparation apparatus includes a holder that holds a sample container and a centrifuge tube, a centrifugation section that centrifuges a specimen stored in the centrifuge tube, a transfer unit that transfers the centrifuge tube between the holder and the centrifugation section, and a dispenser that dispenses a sample stored in the sample container or a specimen prepared based on a sample into the centrifuge tube held in the centrifugation section. The transfer unit transfers the centrifuge tube storing a centrifuged sample or specimen to the holder.

公开(公告)号：US11673141B2

公开(公告)日：2023-06-13

申请号：US17474544

申请日：2021-09-14

申请人： bioMerieux, Inc.

发明人： Joel Patrick Harrison ,  John Kenneth Korte ,  Jeffrey Edward Price

IPC分类号： G01N21/01 ,  G01N15/06 ,  G01N21/51 ,  G01N21/88 ,  G01N21/93 ,  B01L3/00 ,  G01N21/59 ,  G01N21/47 ,  G01N1/10 ,  G01N21/27 ,  G01N33/487 ,  G01N21/03

CPC分类号： B01L3/50853 ,  G01N1/10 ,  G01N15/06 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/4785 ,  G01N21/51 ,  G01N21/5907 ,  G01N21/8806 ,  G01N21/93 ,  G01N33/487 ,  G01N33/48735 ,  B01L2200/14 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/12 ,  G01N21/474 ,  G01N2015/0693 ,  G01N2021/0168 ,  G01N2021/0389 ,  G01N2021/4769 ,  G01N2021/598 ,  G01N2201/126 ,  G01N2201/12707

摘要： A method, computer program product, and apparatus are provided for controlling components of a detection device. The device may detect turbidity of liquid with sensors such as a density sensor and/or nephelometric sensor. A light modulation pattern may reduce or eliminate interference in sensor readings. Readings may be performed during off cycles of an illumination light to reduce interference but to provide improved visibility of a tube. Dark and light sensor readings may be performed with an emitter respectively off or on to account for ambient light in subsequent readings. Readings from the density sensor and/or nephelometric sensor may be used to calculate McFarland values. The device may be zeroed based on an emitter level that results in a sensor reading satisfying a predetermined criterion.

公开(公告)号：US20190234975A1

公开(公告)日：2019-08-01

申请号：US16262823

申请日：2019-01-30

申请人： LIFE TECHNOLOGIES CORPORATION

发明人： Shakila POTHINI ,  Hardeep SANGHA ,  Marc HABERSTROH ,  Puneet SURI ,  Damien LUK

IPC分类号： G01N35/00 ,  B01L9/00 ,  G06K19/07 ,  G06K7/10

CPC分类号： G01N35/00732 ,  B01L3/5085 ,  B01L3/54 ,  B01L3/545 ,  B01L9/00 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/025 ,  B01L2300/0627 ,  B01L2300/0829 ,  G01N35/00871 ,  G01N2035/00742 ,  G01N2035/00782 ,  G01N2035/00811 ,  G01N2035/00851 ,  G01N2035/00881 ,  G06K7/10366 ,  G06K19/0723 ,  G16H10/40 ,  G16H40/67 ,  G16H50/20

摘要： A system for performing a molecular analysis workflow includes a reaction holder or a reaction substrate, such as a multi-well reaction plate, with a reaction holder/substrate RFID tag, and/or a reagent container with a reagent container RFID tag, and an instrument and/or device that includes an RFID reader/writer operable to read and/or write information to and from the reaction holder/substrate RFID tag and/or the reagent container RFID tag. The reaction holder/substrate RFID tag and the reagent container RFID tag can be utilized separately or together to send and receive and store information, for example, for a workflow of a molecular analysis, such as a polymerase chain reaction (PCR).