公开(公告)号：US10180420B2

公开(公告)日：2019-01-15

申请号：US14963576

申请日：2015-12-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Carina Horn ,  Michael Marquant ,  Christine Nortmeyer ,  Volker Unkrig

IPC: G01N27/02 ,  G01N33/49 ,  G01N27/327 ,  G01N21/64 ,  G01N21/78 ,  G01N21/84 ,  G01N27/12 ,  G01N21/77

Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.

公开(公告)号：US20160091482A1

公开(公告)日：2016-03-31

申请号：US14963576

申请日：2015-12-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Carina Horn ,  Michael Marquant ,  Christine Nortmeyer ,  Volker Unkrig

IPC: G01N33/49 ,  G01N21/78 ,  G01N27/12 ,  G01N21/64

CPC classification number: G01N33/492 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8483 ,  G01N27/02 ,  G01N27/12 ,  G01N27/3274 ,  G01N2021/7786

Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.

Abstract translation: 公开了一种用于检测体液中的至少一种分析物的方法，包括执行光学测量，其中至少一种测试化学品接触体液。 测试化学品是适于执行至少一个检测反应的光学测试化学品，其中由于检测反应而改变至少一种可光学检测的性质以提供至少一种光学测量值。 产生至少一个阻抗测量，其中经由阻抗测量电极将至少一个交流电信号施加到体液，并记录至少一个应答信号，并且产生至少一个阻抗测量值。 执行至少一个评估步骤，其中使用至少一个评估算法，并且使用光学测量值和阻抗测量值来确定体液中分析物的浓度。

公开(公告)号：US20140302541A1

公开(公告)日：2014-10-09

申请号：US14310438

申请日：2014-06-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Carina Horn ,  Volker Unkrig

IPC: C12Q1/54

CPC classification number: C12Q1/54 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1486 ,  A61B2562/0295 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/525 ,  G01N2021/7786 ,  G01N2035/00108

Abstract: Methods, devices and test elements are disclosed for detecting at least one analyte in a sample. The methods, devices and test elements are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The methods, devices and test elements correct for an interfering variable such as temperature and or hematocrit in a test element system via a correction factor based upon diffusion of a diffusable label.

Abstract translation: 公开了用于检测样品中至少一种分析物的方法，装置和测试元件。 方法，装置和测试元件用于检测一种或多种分析物，例如体液中的代谢物，特别是葡萄糖。 方法，装置和测试元件通过基于可扩散标签的扩散的校正因子来校正测试元件系统中的干扰变量，例如温度和/或血细胞比容。