公开(公告)号：US09623440B2

公开(公告)日：2017-04-18

申请号：US13747667

申请日：2013-01-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Wolfgang Hofmann ,  Taghi Noormofidi ,  Doris Zahrl

IPC: B05D5/00 ,  B01L3/00 ,  G01N33/543

CPC classification number: B05D5/00 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/161 ,  G01N33/54393

Abstract: A method for at least partially applying a hydrophilic polymer to a measurement channel of a sensor cartridge is provided, which sensor cartridge can be replaceably inserted in an analyzer. The measurement channel comprises at least one sensor element. The method comprises inserting the sensor cartridge into the analyzer, introducing an aqueous solution containing chitosan or a chitosan derivative into the measurement channel of the sensor cartridge, and following a residence time replacing the aqueous chitosan solution with a gaseous or liquid medium, wherein residues of the chitosan or chitosan derivatives remain on the inside surface of the measurement channel and hydrophilize the surface.

公开(公告)号：US20130136657A1

公开(公告)日：2013-05-30

申请号：US13747667

申请日：2013-01-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Wolfgang Hofmann ,  Taghi Noormofidi ,  Doris Zahrl

IPC: B05D5/00

CPC classification number: B05D5/00 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/161 ,  G01N33/54393

Abstract: A method for at least partially applying a hydrophilic polymer to a measurement channel of a sensor cartridge is provided, which sensor cartridge can be replaceably inserted in an analyzer. The measurement channel comprises at least one sensor element. The method comprises inserting the sensor cartridge into the analyzer, introducing an aqueous solution containing chitosan or a chitosan derivative into the measurement channel of the sensor cartridge, and following a residence time replacing the aqueous chitosan solution with a gaseous or liquid medium, wherein residues of the chitosan or chitosan derivatives remain on the inside surface of the measurement channel and hydrophilize the surface.

Abstract translation: 提供了一种用于至少部分地将亲水性聚合物施加到传感器盒的测量通道的方法，该传感器盒可以可替换地插入到分析器中。 测量通道包括至少一个传感器元件。 该方法包括将传感器盒插入分析器中，将含有壳聚糖或壳聚糖衍生物的水溶液引入到传感器盒的测量通道中，并且在用气态或液体介质代替壳聚糖水溶液的停留时间之后， 壳聚糖或壳聚糖衍生物保留在测量通道的内表面上并使表面亲水化。

公开(公告)号：US09194852B2

公开(公告)日：2015-11-24

申请号：US14551758

申请日：2014-11-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Pfeiffer ,  Wolfgang Hofmann ,  Horst Ruether

IPC: G01N33/49 ,  G01N33/50 ,  G01N33/00 ,  B01F11/00

CPC classification number: G01N33/0006 ,  B01F11/0022 ,  B01F11/0034 ,  G01N33/4925 ,  Y10T436/102499 ,  Y10T436/209163 ,  Y10T436/25875

Abstract: A method and an apparatus for accelerating the equilibration of a fluid, typically the reference fluid of an analyzer, are provided, the surface of the fluid being in contact with a gas phase. The device can include a cassette, which can be exchangeably inserted into an analyzer and which holds at least one flexible, gas-tight bag, in which the fluid and the gas phase are accommodated. The cassette or the analyzer can include at least one transmitting element, which can be caused to vibrate and which mechanically contacts the flexible bag in order to input mechanical energy into the liquid in at least one wall region.

Abstract translation: 提供了用于加速流体（通常是分析器的参考流体）的平衡的方法和装置，流体的表面与气相接触。 该装置可以包括盒，其可以可交换地插入到分析器中并且容纳至少一个容纳流体和气相的柔性气密袋。 盒或分​​析器可以包括至少一个传输元件，其可以被引起振动并且机械地接触柔性袋，以便在至少一个壁区域中将机械能输入到液体中。

公开(公告)号：US20150079685A1

公开(公告)日：2015-03-19

申请号：US14551758

申请日：2014-11-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Pfeiffer ,  Wolfgang Hofmann ,  Horst Ruether

IPC: G01N33/00 ,  G01N33/49

CPC classification number: G01N33/0006 ,  B01F11/0022 ,  B01F11/0034 ,  G01N33/4925 ,  Y10T436/102499 ,  Y10T436/209163 ,  Y10T436/25875

Abstract: A method and an apparatus for accelerating the equilibration of a fluid, typically the reference fluid of an analyzer, are provided, the surface of the fluid being in contact with a gas phase. The device can comprise a cassette, which can be exchangeably inserted into an analyzer and which holds at least one flexible, gas-tight bag, in which the fluid and the gas phase are accommodated. The cassette or the analyzer can include at least one transmitting element, which can be caused to vibrate and which mechanically contacts the flexible bag in order to input mechanical energy into the liquid in at least one wall region.

Abstract translation: 提供了用于加速流体（通常是分析器的参考流体）的平衡的方法和装置，流体的表面与气相接触。 该装置可以包括盒，其可以可交换地插入到分析器中并且容纳至少一个容纳流体和气相的柔性气密袋。 盒或分​​析器可以包括至少一个传输元件，其可以被引起振动并且机械地接触柔性袋，以便在至少一个壁区域中将机械能输入到液体中。