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    Method, biomarker and diagnostic agent for detection of high-risk prostate cancer
    7.
    发明授权
    Method, biomarker and diagnostic agent for detection of high-risk prostate cancer 有权

    公开(公告)号：US11226334B2

    公开(公告)日：2022-01-18

    申请号：US16073217

    申请日：2017-02-03

    申请人： J-OIL MILLS, INC. ,  OSAKA UNIVERSITY

    发明人： Yuka Kobayashi ,  Kazutoshi Fujita ,  Norio Nonomura ,  Eiji Miyoshi

    IPC分类号： G01N33/493 ,  G01N33/574

    摘要： [Problem] To provide a method for detecting high-risk prostate cancer, for the purpose of providing useful information, such as necessity of biopsy, to a test-positive patient in a PSA test.
    [Solution] The method for detecting high-risk prostate cancer according to the present invention comprises reacting a PSA contained in a sample composed of urine collected from a human body which is suspected to be suffering from prostate cancer with (1) a fucose α1→6 affinitive lectin which has a characteristic property that the lectin has affinity expressed by a binding constant of 1.0×104 M−1 or more (at 25° C.) for an α1→6 fucose sugar chain No. 405. The fucose α1→6 affinitive lectin is preferably (2) a fucose α1→6 specific lectin which has a characteristic property that the lectin has a binding constant of 1.0×104 M−1 or less (at 25° C.) for a sugar chain No. 003 that does not contain α1→6 fucose and a glycolipid-type sugar chain No. 909 that does not contain α1→6 fucose.