公开(公告)号：US20190256827A1

公开(公告)日：2019-08-22

申请号：US16227279

申请日：2018-12-20

Applicant: STC.UNM

Inventor： Fu-Sen Liang ,  Tingjun Chen ,  Dan Gao

IPC: C12N9/10 ,  C12N9/22 ,  C12N15/11 ,  C12N15/85

Abstract: An epigenome editing system generally includes three exogenous coding regions. The first exogenous coding region encodes a first polypeptide that includes an epigenetic editing domain and a domain that, in the presence of an inducer, forms a complex with a second polypeptide. The second exogenous coding region encodes the second polypeptide, which includes a dCas9 domain and a domain that, in the presence of the inducer, forms a complex with the first polypeptide. The third exogenous coding region encodes an sgRNA sequence that targets the dCas9 domain to a genomic locus.

公开(公告)号：US10907219B2

公开(公告)日：2021-02-02

申请号：US15119506

申请日：2015-02-18

Applicant: STC.UNM ,  Fu-Sen Liang ,  Wei Wang

Inventor： Fu-Sen Liang ,  Wei Wang

IPC: C12Q1/68 ,  C12Q1/6897

Abstract: This disclosure describes compositions and methods that involve a first modular component and a second modular component. The first modular component includes a first target molecule coupled to a first dimerizing moiety. The second modular component includes a second target molecule coupled to a second dimerizing moiety. The first dimerizing moiety dimerizes with the second dimerizing moiety when the first dimerizing moiety binds a chemical induced proximity (CIP) inducer.

公开(公告)号：US10093929B2

公开(公告)日：2018-10-09

申请号：US15029307

申请日：2014-10-10

Applicant: STC.UNM

Inventor： Fu-Sen Liang

IPC: C07H21/04 ,  C07H21/02 ,  C12N15/113 ,  C12N15/11

Abstract: This disclosure describes modular miRNA regulator molecules and methods of using modular miRNA regulator molecules. Generally, the modular miRNA regulator molecules include a recognition module and an inhibition module. Generally, the recognition module includes a polynucleotide in which at least a portion of the polynucleotide recognizes at least a portion of a preselected pre-miRNA. Generally, the inhibition module includes a moiety that inhibits nuclease processing of the preselected pre-RNA to a mature RNA.

公开(公告)号：US20170226595A1

公开(公告)日：2017-08-10

申请号：US15119506

申请日：2015-02-18

Applicant: STC.UNM

Inventor： Fu-Sen Liang ,  Wei Wang

IPC: C12Q1/68

CPC classification number: C12Q1/6897 ,  C12N2510/00

Abstract: This disclosure describes compositions and methods that involve a first modular component and a second modular component. The first modular component includes a first target molecule coupled to a first dimerizing moiety. The second modular component includes a second target molecule coupled to a second dimerizing moiety. The first dimerizing moiety dimerizes with the second dimerizing moiety when the first dimerizing moiety binds a chemical induced proximity (CIP) inducer.