公开(公告)号：US20150133515A1

公开(公告)日：2015-05-14

申请号：US14534993

申请日：2014-11-06

Applicant: STC.UNM

Inventor： ALEXANDRE CHIGAEV ,  LARRY A. SKLAR

IPC: G01N33/50 ,  A61K31/42 ,  A61K31/357 ,  A61K31/197

CPC classification number: G01N33/5041 ,  A61K31/195 ,  A61K31/197 ,  A61K31/357 ,  A61K31/36 ,  A61K31/42 ,  G01N33/5055 ,  G01N33/68 ,  G01N2333/70546 ,  G01N2333/7055 ,  G01N2500/04 ,  G01N2500/10

Abstract: This invention relates generally to integrin ligand discovery and to a method of integrin ligand discovery based upon induction of ligand-induced epitopes. Such ligands have the potential to be active agent as anti-inflammatory, anti-angiogenesis and/or anti-thrombotic agents and for the treatment of integrin mediated diseases and/or conditions.

Abstract translation: 本发明一般涉及整联蛋白配体发现和基于诱导配体诱导表位的整联蛋白配体发现的方法。 这样的配体具有作为抗炎，抗血管生成和/或抗血栓形成剂的活性剂的潜力，并且用于治疗整联蛋白介导的疾病和/或病症。

公开(公告)号：US20160178504A1

公开(公告)日：2016-06-23

申请号：US15006817

申请日：2016-01-26

Applicant: STC.UNM

Inventor： LARRY A. SKLAR ,  BRUCE EDWARDS ,  FREDERICK KUCKUCK

IPC: G01N15/14 ,  G01N21/64

CPC classification number: G01N15/1436 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N21/6486 ,  G01N35/0099 ,  G01N35/085 ,  G01N35/1095 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1413 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2201/06113 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.

Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流动流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。