公开(公告)号：US20190219045A1

公开(公告)日：2019-07-18

申请号：US16366258

申请日：2019-03-27

申请人： SARTORIUS LAB INSTRUMENTS GMBH & CO. KG

发明人： Jonas BODE ,  Malte STAENDER

IPC分类号： F04B39/08 ,  F04B39/10

CPC分类号： F04B39/08 ,  A61M5/1408 ,  F04B39/10 ,  G01G17/04 ,  G01N35/085

摘要： A distributor head for a suction pump which includes a housing (12), a pump port (16) configured to apply a negative pressure, and a plurality of hollow needles (18). The hollow needles are fixed to the housing (12), are connected in a liquid-tight manner to the pump port (16), and are arranged parallel to and at a distance from one another. Individual connecting paths (34) of the hollow needles (18) to the pump port (16) include respective, independently operable control valves (36).

公开(公告)号：US20180193838A1

公开(公告)日：2018-07-12

申请号：US15861225

申请日：2018-01-03

申请人： The University of Chicago

发明人： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song Baca ,  Lewis Spencer Roach

IPC分类号： B01L3/00 ,  C12Q1/44 ,  B01F3/08 ,  B01F5/06 ,  B01F13/00 ,  C12P19/34 ,  B01J19/00 ,  G01N15/14 ,  G01N35/08 ,  B01L7/00 ,  B82Y30/00

CPC分类号： B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US09968933B2

公开(公告)日：2018-05-15

申请号：US15673955

申请日：2017-08-10

申请人： The University of Chicago

发明人： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song Baca ,  Lewis Spencer Roach

IPC分类号： B01L3/00 ,  B01L7/00 ,  B01J19/00 ,  B01F3/08 ,  B01F5/06 ,  B01F13/00 ,  G01N15/10 ,  B01F5/04

CPC分类号： B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US20180008984A1

公开(公告)日：2018-01-11

申请号：US15687856

申请日：2017-08-28

申请人： 10X Genomics, Inc.

发明人： Rajiv Bharadwaj ,  Kevin Ness ,  Debkishore Mitra ,  Donald Masquelier ,  Anthony Makarewicz ,  Christopher Hindson ,  Benjamin Hindson ,  Serge Saxonov

IPC分类号： B01L3/00 ,  B01L3/02 ,  G01N35/10 ,  G01N35/00 ,  G01N35/08

CPC分类号： B01L3/502761 ,  B01L3/0241 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2400/049 ,  B01L2400/086 ,  G01N35/085 ,  G01N2035/00237 ,  G01N2035/1034

摘要： The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.

公开(公告)号：US09851347B2

公开(公告)日：2017-12-26

申请号：US14403845

申请日：2013-07-05

申请人： Creoptix Ltd.

发明人： Kaspar Cottier

IPC分类号： G01N33/53 ,  G01N35/08

CPC分类号： G01N33/5302 ,  G01N35/085

摘要： A flow conduit system (100, 200a, 200b) suitable for biochemical sensing, the flow conduit system (100, 200a, 200b) having a first flow cell conduit (1) with one or more sensing areas for biochemical sensing; a first selector valve (4); a first inlet/outlet conduit (2) which fluidly connects the first flow cell conduit (1) to the first selector valve (4); a first injection conduit (6) having a first end and a second end; a second injection conduit (7) having a first end and a second end; a fluid injecting means (8) fluidly connected to the second ends of each of the first and second injection conduits (6, 7) so that the fluid injecting means can selectively inject fluids into the first and/or second injection conduits (6,7); wherein the first injection conduit (6) is fluidly connected, at its first end, to the first inlet/outlet conduit (2) by a valveless junction (9), and the second injection conduits (6) is fluidly connected, at its first end, to the first inlet/outlet conduit (2) by a valveless junction (9).

公开(公告)号：US09839893B2

公开(公告)日：2017-12-12

申请号：US14836432

申请日：2015-08-26

申请人： The University of Chicago

发明人： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song ,  Lewis Spencer Roach

IPC分类号： B01L3/00 ,  B01J19/00 ,  B01F5/06 ,  B01F13/00 ,  G01N35/08 ,  C12P19/34 ,  C12Q1/44 ,  B82Y30/00 ,  G01N15/14

CPC分类号： B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US09731295B2

公开(公告)日：2017-08-15

申请号：US14402055

申请日：2013-05-17

申请人： C2 DIAGNOSTICS

发明人： Henri Champseix

IPC分类号： G01N33/00 ,  B01L3/00 ,  G01N35/00 ,  G01N35/08 ,  G01N35/10

CPC分类号： B01L3/563 ,  B01L3/565 ,  G01N35/00029 ,  G01N35/085 ,  G01N35/1002 ,  G01N35/1095

摘要： A fluid connection device is provided for biological analysis apparatuses, intended to simultaneously connect a plurality of fluid conduits and at least one fluidic component including a connecting surface with a plurality of fluid ports, the device having: (i) a holding plate, (ii) removable attachment structure capable of pressing the holding plate against the connecting surface, (iii) connectors suitable for being fixed to the ends of the fluid conduits and provided with a seal suitable for allowing a sealed connection to be made between the connectors and the fluid ports, holding plate including through-openings opposite the fluid ports and being shaped in such a way as to be able to receive the connectors in through-openings and to hold them pressed against the connecting surface. A biological analysis apparatus implementing the device is also provided.

公开(公告)号：US09689786B2

公开(公告)日：2017-06-27

申请号：US14410019

申请日：2013-06-26

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE MONTPELLIER I ,  UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES

发明人： Hervé Cottet ,  Luca Cipelletti ,  Michel Martin ,  Jean-Philippe Biron

IPC分类号： G01N31/00 ,  G01N15/02 ,  G01N35/08

CPC分类号： G01N15/0205 ,  G01N15/02 ,  G01N15/0211 ,  G01N35/085

摘要： A method for determining the size distribution of a mixture of molecule or particle species including the steps of: injecting a sample of the mixture to be analyzed inside a capillary in which an eluent is flowing; transporting the sample injected along the capillary from an injection section to a detection section thereof, in experimental conditions suitable to generate a Taylor dispersion phenomenon that is measurable at the level of the detection section; generating, by a suitable sensor included in the detection section, a signal characteristic of the Taylor dispersion of the transported sample; processing the detection signal in order to obtain an experimental Taylor signal S(t); and analyzing the experimental Taylor signal Ŝ(t), wherein the step of analyzing an experimental Taylor signal Ŝ(t) of a sample of the mixture consists of searching an amplitude distribution P(G(c)) that allows the experimental Taylor signal Ŝ(t)′ to be broken down into a sum of Gaussian functions.

公开(公告)号：US09494613B2

公开(公告)日：2016-11-15

申请号：US13375968

申请日：2010-05-18

申请人： Christian Oberndorfer ,  Michael Winkler ,  Marco Zuern

发明人： Christian Oberndorfer ,  Michael Winkler ,  Marco Zuern

IPC分类号： G05D7/00 ,  G01N35/08 ,  B01F5/06 ,  B01F13/00 ,  B01L3/00 ,  G01N35/10 ,  G01N35/00

CPC分类号： G01N35/085 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2400/0487 ,  G01N35/1097 ,  G01N2035/00326

摘要： A modular flow injection analysis system has a sample connection, a reagent inflow and a media discharge. The analysis system is formed of a plurality of functional modules stacked one on top of the other. These functional modules include a metering module including a metering channel having an inlet and an outlet, a mixing module including a mixing channel having an inlet and an outlet, an analysis module including a media chamber connected to the outlet of the mixing channel, and a media control module. The modules are connected by aligned media channels. These media channels replace the conventional tube connections. They are connected automatically when the modules are fitted together.

摘要翻译： 模块化流动注射分析系统具有样品连接，试剂流入和介质放电。 分析系统由多个功能模块形成，多个功能模块彼此堆叠。 这些功能模块包括计量模块，其包括具有入口和出口的计量通道，混合模块包括具有入口和出口的混合通道，分析模块，包括连接到混合通道的出口的介质室，以及 媒体控制模块 模块通过对齐的媒体通道连接。 这些介质通道取代传统的管连接。 当模块安装在一起时，它们将自动连接。

公开(公告)号：US20150060614A1

公开(公告)日：2015-03-05

申请号：US14386964

申请日：2013-03-14

申请人： HORIBA ABX SAS

发明人： Nathalie Henon

IPC分类号： F16M11/04 ,  G01N15/14 ,  G01N15/02 ,  G01N35/08

CPC分类号： F16M11/043 ,  G01B5/0004 ,  G01N15/0205 ,  G01N15/1459 ,  G01N35/085 ,  G01N2015/149

摘要： The subject of the invention is a device for positioning an object in space, comprising at least 4 plates, each one able to move with respect to another of said plates which is contiguous with it along one of the 3 axes of space, it being possible for the movement of one plate with respect to another plate to be guided by a tenon/mortise assembly in which said tenon is secured to one of the plates and its mortise is produced in the other plate, the spatial orientation of each of the tenon/mortise assemblies being different from the other 2 and along one of the 3 axes of space.

摘要翻译： 本发明的主题是用于将物体定位在空间中的装置，包括至少4个板，每个板能够相对于沿着3个空间轴之一与其相邻的另一个板移动，这是可能的 对于一个板相对于另一个板的运动，由榫头/榫组件引导，其中所述榫头固定到其中一个板，并且在另一个板中产生其榫眼，每个榫头/ 榫眼组件与其他2和沿着3个空间轴之一不同。