公开(公告)号：US09561389B2

公开(公告)日：2017-02-07

申请号：US15179289

申请日：2016-06-10

Applicant: STC.UNM

Inventor： Shuang Luan ,  Lijun Ma ,  Zhe Chen

IPC: A61N5/00 ,  A61N5/10

CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.

Abstract translation: 基于光子的放射外科手术广泛用于治疗局部和局部肿瘤。 提高放射外科手术质量的关键是提高肿瘤内部高剂量区域到附近健康组织和结构的低剂量区域的剂量衰减率。 动态光子绘画（DPP）通过沿着动态轨迹移动光束源来处理目标物体进一步增加剂量衰减速率，其中光束源的速度，方向和均匀剂量率在照射期间不断变化。 DPP产生与质子Bragg峰值相当的剂量梯度，并优于GammaKnife®放射外科手术。

公开(公告)号：US09630023B2

公开(公告)日：2017-04-25

申请号：US14107541

申请日：2013-12-16

Applicant: STC.UNM

Inventor： Shuang Luan ,  Nathan Swanson ,  Lijun Ma

IPC: A61B6/00 ,  A61N5/10 ,  A61B90/10 ,  A61B34/10

CPC classification number: A61N5/1031 ,  A61B34/10 ,  A61B90/10 ,  A61B2090/101 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1084

Abstract: The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

公开(公告)号：US20140107394A1

公开(公告)日：2014-04-17

申请号：US14107541

申请日：2013-12-16

Applicant: STC.UNM

Inventor： Shuang Luan ,  Nathan Swanson ,  Lijun Ma

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61B34/10 ,  A61B90/10 ,  A61B2090/101 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1084

Abstract: The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

Abstract translation: 本发明是基于“剂量绘画”的概念，利用伽玛刀C和Perfexion单元上的机器人患者定位系统开发伽玛刀放射外科手术的动态方案和系统。 由伽玛刀单元创建的球形高剂量体积将被视为3D球形“画笔”，并且减少治疗计划以找到该“画笔”最佳路线来“绘制”3D肿瘤体积。 在剂量绘画概念下，伽玛刀放射外科手术变得动态，病人在机器人定位系统下连续移动。

公开(公告)号：US09827446B2

公开(公告)日：2017-11-28

申请号：US15388201

申请日：2016-12-22

Applicant: STC.UNM ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Shuang Luan ,  Lijun Ma ,  Zhe Chen

IPC: A61N5/00 ,  A61N5/10 ,  A61B6/00

CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.