公开(公告)号：US20140093901A1

公开(公告)日：2014-04-03

申请号：US13952439

申请日：2013-07-26

Applicant: Korea Advanced Institute Of Science and Technology ,  Samsung Electronics Co., Ltd.

Inventor： Kyu-sang LEE ,  Tae-yong KIM ,  Seung-bum SOHN ,  Hyun-min KOO ,  Jae-chan PARK ,  Sang-yup LEE

IPC: G06F19/12 ,  C12P7/42

CPC classification number: G16B5/00 ,  C12P7/42

Abstract: Use of a metabolic network model for analyzing metabolic characteristics of microorganisms for producing a metabolic product, such as 3HP enabling estimation of productivity and cell growth speed of microorganisms, optimizing new metabolic pathway, and providing transformed microorganisms that may produce a specific metabolic product with high efficiency.

Abstract translation: 使用代谢网络模型来分析用于产生代谢产物的微生物的代谢特征，例如3HP，其能够估计微生物的生产力和细胞生长速度，优化新的代谢途径，以及提供可产生具有高的代谢产物的转化微生物 效率。

公开(公告)号：US20140030781A1

公开(公告)日：2014-01-30

申请号：US13952410

申请日：2013-07-26

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kyu-sang LEE ,  Young-min LEE ,  Woo-yong LEE ,  Hyun-min KOO ,  Jin-woo KIM ,  Young-kyoung PARK ,  Jin-hwan PARK ,  Hwa-young CHO ,  Jae-chan PARK

IPC: C12P7/18 ,  C12N15/77

CPC classification number: C12P7/18 ,  C12N9/0006 ,  C12N15/52 ,  C12N15/77 ,  C12Y101/01037 ,  C12Y101/05004 ,  Y02P20/52

Abstract: A recombinantly modified Corynebacterium glutamicum microorganism with an improved 1,4-butanediol (1,4-BDO) productivity relative to an unmodified Corynebacterium glutamicum microorganism, wherein activity of an enzyme catalyzing a conversion reaction between malate and oxaloacetate is inactivated or reduced relative to an unmodified Corynebacterium glutamicum microorganism, as well as a method of making and using same.

Abstract translation: 相对于未修饰的谷氨酸棒杆菌微生物，具有改进的1,4-丁二醇（1,4-BDO）生产力的重组修饰的谷氨酸棒杆菌微生物，其中催化苹果酸和草酰乙酸之间的转化反应的酶的活性相对于 未经修饰的谷氨酸棒杆菌微生物，以及其制备和使用方法。

公开(公告)号：US20140257773A1

公开(公告)日：2014-09-11

申请号：US14200438

申请日：2014-03-07

Applicant: Samsung Electronics Co., Ltd.

Inventor： So-young LEE ,  So-jeong YUN ,  Tae-yong KIM ,  Jae-chan PARK ,  Jin-woo PARK ,  Kyu-sang LEE

IPC: G06F17/50

CPC classification number: G16C20/30

Abstract: Provided is a method of generating a toxicity prediction model for a microorganism, a method of predicting the toxicity of a chemical substance to a microorganism using the toxicity prediction model, and a method of assigning priorities to biosynthetic pathways for a target material using the toxicity prediction method.

Abstract translation: 提供了生成微生物的毒性预测模型的方法，使用毒性预测模型来预测化学物质对微生物的毒性的方法，以及使用毒性预测为靶物质生物合成途径赋予优先权的方法 方法。