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    DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE
    1.
    发明申请
    DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE 有权
    用于生物组织的内部注射用于组织的装置和方法

    公开(公告)号：US20100063475A1

    公开(公告)日：2010-03-11

    申请号：US12621037

    申请日：2009-11-18

    申请人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    发明人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    IPC分类号： A61M31/00 ,  A61M5/32

    CPC分类号： A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00247 ,  A61B2017/00876 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M5/32 ,  A61M2025/0086 ,  A61M2025/0087

    摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

    摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以平移到与轴垂直的针驱动力​​。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

    Devices and methods for interstitial injection of biologic agents into tissue
    2.
    发明授权
    Devices and methods for interstitial injection of biologic agents into tissue 有权
    将生物制剂间插注入组织的装置和方法

    公开(公告)号：US07744562B2

    公开(公告)日：2010-06-29

    申请号：US11545197

    申请日：2006-10-10

    申请人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    发明人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    IPC分类号： A61M5/30 ,  A61M31/00 ,  A61B18/18

    CPC分类号： A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00247 ,  A61B2017/00876 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M5/32 ,  A61M2025/0086 ,  A61M2025/0087

    摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

    摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以平移到与轴垂直的针驱动力​​。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

    Devices and methods for interstitial injection of biologic agents into tissue
    3.
    发明授权
    Devices and methods for interstitial injection of biologic agents into tissue 有权
    将生物制剂间插注入组织的装置和方法

    公开(公告)号：US08273072B2

    公开(公告)日：2012-09-25

    申请号：US12621037

    申请日：2009-11-18

    申请人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    发明人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    IPC分类号： A61M31/00

    CPC分类号： A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00247 ,  A61B2017/00876 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M5/32 ,  A61M2025/0086 ,  A61M2025/0087

    摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

    摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以平移到与轴垂直的针驱动力​​。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

    Cardiac mapping instrument with shapeable electrode
    9.
    发明授权
    Cardiac mapping instrument with shapeable electrode 有权
    具有可塑电极的心脏测绘仪

    公开(公告)号：US08623010B2

    公开(公告)日：2014-01-07

    申请号：US12480926

    申请日：2009-06-09

    申请人： Jon M. Ocel ,  Roderick E. Briscoe ,  David E. Francischelli ,  Scott E. Jahns ,  James R. Keogh ,  Katherine S. Jolly ,  Matthew D. Bonner

    发明人： Jon M. Ocel ,  Roderick E. Briscoe ,  David E. Francischelli ,  Scott E. Jahns ,  James R. Keogh ,  Katherine S. Jolly ,  Matthew D. Bonner

    IPC分类号： A61B18/14

    CPC分类号： A61B5/042 ,  A61B5/7475 ,  A61B18/14 ,  A61B2017/2927 ,  A61B2018/1472 ,  A61N1/056

    摘要： An instrument including an elongated shaft and a non-conductive handle is disclosed. The shaft defines a proximal section and a distal section. The distal section forms an electrically conductive tip. Further, the shaft is adapted to be transitionable from a straight state to a first bent state. The shaft is capable of independently maintaining the distinct shapes associated with the straight state and the first bent state. The handle is rigidly coupled to the proximal section of the shaft. The instrument is useful for epicardial pacing and/or mapping of the heart for temporary pacing on a beating heart, for optimizing the placement of ventricular leads for the treatment of patients with congestive heart failure and ventricular dysynchrony and/or for use in surgical ablation procedures.

    摘要翻译： 公开了一种包括细长轴和非导电手柄的仪器。 轴限定近端部分和远端部分。 远侧部分形成导电尖端。 此外，轴适于从直状态转变到第一弯曲状态。 轴能够独立地保持与直线状态和第一弯曲状态相关联的不同形状。 手柄刚性地联接到轴的近端部分。 该仪器可用于心脏起搏和/或心脏在心脏跳动中临时起搏的作用，以优化用于治疗患有充血性心力衰竭和心室异常不适和/或用于外科手术切除手术的患者的心室导线的放置 。