公开(公告)号：US09804157B1

公开(公告)日：2017-10-31

申请号：US14206612

申请日：2014-03-12

Applicant: SENOMYX, INC.

Inventor： Guy Servant ,  Nicole Servant

IPC: G01N33/567 ,  G01N33/566

CPC classification number: G01N33/566 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20

Abstract: This invention relates to assays which screen for compounds that modulate taste elicited by the T1R2/T1R3 sweet taste receptor which include a novel counter screen to eliminate false positives. In addition, the invention contemplates assays which screen for compounds that modulate taste elicited by the T1R1/T1R3 umami taste receptor which include a novel counter screen to eliminate false positives. Preferably the assays are conducted in high throughput format thereby enabling the screening of many hundreds of different compounds whereby the counter screen significantly improves assay efficiency. Further, the invention relates to the use of the compounds identified in the subject screening assays to modulate T1R associated taste perception.

公开(公告)号：US10281467B2

公开(公告)日：2019-05-07

申请号：US15724407

申请日：2017-10-04

Applicant: SENOMYX, INC.

Inventor： Guy Servant ,  Nicole Servant

IPC: G01N33/566

Abstract: This invention relates to assays which screen for compounds that modulate taste elicited by the T1R2/T1R3 sweet taste receptor which include a novel counter screen to eliminate false positives. In addition, the invention contemplates assays which screen for compounds that modulate taste elicited by the T1R1/T1R3 umami taste receptor which include a novel counter screen to eliminate false positives. Preferably the assays are conducted in high throughput format thereby enabling the screening of many hundreds of different compounds whereby the counter screen significantly improves assay efficiency. Further, the invention relates to the use of the compounds identified in the subject screening assays to modulate T1R associated taste perception.

公开(公告)号：US20190277845A1

公开(公告)日：2019-09-12

申请号：US16363106

申请日：2019-03-25

Applicant: Senomyx, Inc.

Inventor： Guy Servant ,  Nicole Servant

IPC: G01N33/566

Abstract: This invention relates to assays which screen for compounds that modulate taste elicited by the T1R2/T1R3 sweet taste receptor which include a novel counter screen to eliminate false positives. In addition, the invention contemplates assays which screen for compounds that modulate taste elicited by the T1R1/T1R3 umami taste receptor which include a novel counter screen to eliminate false positives. Preferably the assays are conducted in high throughput format thereby enabling the screening of many hundreds of different compounds whereby the counter screen significantly improves assay efficiency. Further, the invention relates to the use of the compounds identified in the subject screening assays to modulate T1R associated taste perception.

公开(公告)号：US20180106801A1

公开(公告)日：2018-04-19

申请号：US15724407

申请日：2017-10-04

Applicant: Senomyx, Inc.

Inventor： Guy SERVANT ,  Nicole Servant

IPC: G01N33/566

CPC classification number: G01N33/566 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20

Abstract: This invention relates to assays which screen for compounds that modulate taste elicited by the T1R2/T1R3 sweet taste receptor which include a novel counter screen to eliminate false positives. In addition, the invention contemplates assays which screen for compounds that modulate taste elicited by the T1R1/T1R3 umami taste receptor which include a novel counter screen to eliminate false positives. Preferably the assays are conducted in high throughput format thereby enabling the screening of many hundreds of different compounds whereby the counter screen significantly improves assay efficiency. Further, the invention relates to the use of the compounds identified in the subject screening assays to modulate T1R associated taste perception.

公开(公告)号：US20170119032A1

公开(公告)日：2017-05-04

申请号：US15336579

申请日：2016-10-27

Applicant: Senomyx, Inc.

Inventor： Andrew Patron ,  Rama Manam ,  Justin Colquitt ,  Nicole Servant ,  Chris Edano Noriega ,  Jeffrey R. Hammaker ,  Nicole Gonsalves

IPC: A23L27/20 ,  A23L2/52 ,  A23P10/20 ,  C07J17/00

CPC classification number: A23L27/204 ,  A23L2/385 ,  A23L2/52 ,  A23L2/60 ,  A23L27/00 ,  A23L27/36 ,  A23P10/20 ,  A23V2002/00 ,  C07J9/00 ,  C07J17/005

Abstract: Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods of increasing the sweet taste of ingestible compositions. Furthermore, methods for preparing the compounds are also disclosed.