-
公开(公告)号:US20150011565A1
公开(公告)日:2015-01-08
申请号:US14373355
申请日:2013-01-25
发明人: Thomas David McCarthy , Alan Naylor
IPC分类号: C07D295/185 , C07D231/12
CPC分类号: C07D241/04 , C07D231/12 , C07D243/08 , C07D295/185 , C07D403/04 , C07D413/04 , C07D413/06
摘要: The present invention relates to heterocyclic compounds useful for antagonizing angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperazine and diazepine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.
摘要翻译: 本发明涉及可用于拮抗血管紧张素II型2型(AT2)受体的杂环化合物。 更具体地,本发明涉及哌嗪和二氮杂化合物,其含有它们的组合物及其在治疗或预防与AT2受体功能相关的病症或疾病的方法中的用途,包括神经性疼痛,炎性疼痛,与神经元超敏反应相关的病症,神经传导速度受损,细胞 增生障碍,与骨吸收和骨形成之间的不平衡相关的疾病以及与异常神经再生有关的疾病。
-
公开(公告)号:US20150218180A1
公开(公告)日:2015-08-06
申请号:US14373357
申请日:2013-01-25
发明人: Thomas David McCarthy , Alan Naylor
IPC分类号: C07D491/056 , C07D211/60 , C07D401/04 , C07D471/04
CPC分类号: C07D491/056 , C07D211/60 , C07D401/04 , C07D471/04 , C07D491/048 , C07D495/04
摘要: The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.
摘要翻译: 本发明涉及可用于拮抗血管紧张素II型2型(AT2)受体的杂环化合物。 更具体地,本发明涉及哌啶化合物,含有它们的组合物及其在治疗或预防与AT2受体功能相关的病症或疾病的方法中的用途,包括神经性疼痛,炎性疼痛,与神经元超敏反应相关的病症,神经传导速度受损,细胞增殖紊乱 ,与骨吸收和骨形成之间的不平衡相关的疾病以及与异常神经再生相关的疾病。
-
公开(公告)号:US20140378430A1
公开(公告)日:2014-12-25
申请号:US14370737
申请日:2013-01-04
发明人: Thomas David McCarthy , Alan Naylor
IPC分类号: C07D498/10 , C07D209/42 , C07D413/04 , C07D401/04 , C07D403/04 , C07D401/12 , C07D409/04 , C07D205/04 , C07D207/14 , C07D207/16 , C07D471/10
CPC分类号: C07D498/10 , C07D205/04 , C07D207/14 , C07D207/16 , C07D207/22 , C07D209/18 , C07D209/42 , C07D209/94 , C07D401/04 , C07D401/12 , C07D403/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D498/04
摘要: The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.
摘要翻译: 本发明涉及可用于拮抗血管紧张素II型2型(AT2)受体的杂环化合物。 更具体地说,本发明涉及吡咯烷和氮杂环丁烷化合物,含有它们的组合物及其在治疗或预防与AT2受体功能相关的病症或疾病的方法中的用途,包括神经性疼痛,炎性疼痛,与神经元超敏反应相关的病症,神经传导速度受损,细胞 增生障碍,与骨吸收和骨形成之间的不平衡相关的疾病以及与异常神经再生有关的疾病。
-
-