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    Heterocyclic compounds and methods for their use
    1.
    发明申请
    Heterocyclic compounds and methods for their use 有权
    杂环化合物及其使用方法

    公开(公告)号：US20150218180A1

    公开(公告)日：2015-08-06

    申请号：US14373357

    申请日：2013-01-25

    申请人： Thomas David McCarthy ,  Alan Naylor ,  Spinifex Pharmaceuticals Pty Ltd

    发明人： Thomas David McCarthy ,  Alan Naylor

    IPC分类号： C07D491/056 ,  C07D211/60 ,  C07D401/04 ,  C07D471/04

    CPC分类号： C07D491/056 ,  C07D211/60 ,  C07D401/04 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

    摘要： The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

    摘要翻译： 本发明涉及可用于拮抗血管紧张素II型2型（AT2）受体的杂环化合物。 更具体地，本发明涉及哌啶化合物，含有它们的组合物及其在治疗或预防与AT2受体功能相关的病症或疾病的方法中的用途，包括神经性疼痛，炎性疼痛，与神经元超敏反应相关的病症，神经传导速度受损，细胞增殖紊乱 ，与骨吸收和骨形成之间的不平衡相关的疾病以及与异常神经再生相关的疾病。

    Heterocyclic Compounds and Methods For Their Use
    4.
    发明申请
    Heterocyclic Compounds and Methods For Their Use 审中-公开
    杂环化合物及其使用方法

    公开(公告)号：US20150011565A1

    公开(公告)日：2015-01-08

    申请号：US14373355

    申请日：2013-01-25

    申请人： Spinifex Pharmaceuticals Pty Ltd

    发明人： Thomas David McCarthy ,  Alan Naylor

    IPC分类号： C07D295/185 ,  C07D231/12

    CPC分类号： C07D241/04 ,  C07D231/12 ,  C07D243/08 ,  C07D295/185 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06

    摘要： The present invention relates to heterocyclic compounds useful for antagonizing angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperazine and diazepine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

    摘要翻译： 本发明涉及可用于拮抗血管紧张素II型2型（AT2）受体的杂环化合物。 更具体地，本发明涉及哌嗪和二氮杂化合物，其含有它们的组合物及其在治疗或预防与AT2受体功能相关的病症或疾病的方法中的用途，包括神经性疼痛，炎性疼痛，与神经元超敏反应相关的病症，神经传导速度受损，细胞 增生障碍，与骨吸收和骨形成之间的不平衡相关的疾病以及与异常神经再生有关的疾病。

    Contraceptive composition
    9.
    发明授权
    Contraceptive composition 有权
    避孕组合物

    公开(公告)号：US08193248B2

    公开(公告)日：2012-06-05

    申请号：US12294024

    申请日：2007-03-21

    申请人： Thomas David McCarthy

    发明人： Thomas David McCarthy

    IPC分类号： A01N37/18 ,  A61K31/16

    CPC分类号： A61K31/785 ,  Y10S977/754

    摘要： The present invention relates to a contraceptive composition including an effective amount of a dendrimer compound including one or more naphthyl disulphonic acid surface groups, or a pharmaceutically acceptable salt or solvate of the dendrimer compound; and a pharmaceutically acceptable carrier, excipient and/or diluent therefor. The contraceptive composition may also exhibit antimicrobial activity. The invention also relates to a method of selectively reducing or preventing conception in a female animal, including a human, which method includes administering to the animal an effective amount of a contraceptive composition which composition includes an effective amount of a dendrimer compound including one or more naphthyl disulphonic acid surface groups, or a pharmaceutically acceptable salt or solvate of the dendrimer compound; and a pharmaceutically acceptable carrier, excipient and/or diluent therefor.

    摘要翻译： 本发明涉及一种避孕组合物，其包含有效量的包含一个或多个萘基二磺酸表面基团的树枝状大分子化合物，或其树枝状大分子化合物的药学上可接受的盐或溶剂合物; 和其药学上可接受的载体，赋形剂和/或稀释剂。 避孕组合物还可以表现出抗微生物活性。 本发明还涉及在女性动物（包括人）中选择性地减少或预防受孕的方法，该方法包括向动物施用有效量的避孕组合物，该组合物包含有效量的包括一种或多种的树突状化合物 萘基二磺酸表面基团，或其树枝状大分子化合物的药学上可接受的盐或溶剂合物; 和其药学上可接受的载体，赋形剂和/或稀释剂。

    DELIVERY SYSTEM
    10.
    发明申请
    DELIVERY SYSTEM 有权
    输送系统

    公开(公告)号：US20100252050A1

    公开(公告)日：2010-10-07

    申请号：US12090580

    申请日：2006-02-01

    申请人： Owen Timothy Grogan ,  Thomas David McCarthy ,  Scott Andrew Henderson

    发明人： Owen Timothy Grogan ,  Thomas David McCarthy ,  Scott Andrew Henderson

    IPC分类号： A61F6/04 ,  A61K31/785 ,  A61P31/00 ,  A61P15/16 ,  A61P31/18 ,  A61P31/22

    CPC分类号： A61K9/0034 ,  A01N41/04

    摘要： A microbicidal delivery system including: a microbicidal composition including a microbicidal compound including a dendrimer including one or more surface groups of formula (IV); a microbicidally active derivative thereof, or pharmaceutically acceptable salt or solvate thereof; and a carrier, excipient or diluent therefor; and a prophylactic device; the microbicidal composition being carried on a surface of the prophylactic device and being compatible therewith.

    摘要翻译： 一种杀菌剂输送系统，包括：杀菌组合物，其包含包含一种或多种式（IV）表面基团的树枝状大分子的杀菌化合物; 其杀微生物活性衍生物或其药学上可接受的盐或溶剂合物; 及其载体，赋形剂或稀释剂; 和预防装置; 所述杀微生物组合物携带在所述预防装置的表面上并与之相容。