利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

74 条记录 (耗时 0.034 秒)

    Heterocyclic compounds and methods for their use
    1.
    发明申请
    Heterocyclic compounds and methods for their use 有权
    杂环化合物及其使用方法

    公开(公告)号：US20150218180A1

    公开(公告)日：2015-08-06

    申请号：US14373357

    申请日：2013-01-25

    申请人： Thomas David McCarthy ,  Alan Naylor ,  Spinifex Pharmaceuticals Pty Ltd

    发明人： Thomas David McCarthy ,  Alan Naylor

    IPC分类号： C07D491/056 ,  C07D211/60 ,  C07D401/04 ,  C07D471/04

    CPC分类号： C07D491/056 ,  C07D211/60 ,  C07D401/04 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

    摘要： The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

    摘要翻译： 本发明涉及可用于拮抗血管紧张素II型2型（AT2）受体的杂环化合物。 更具体地，本发明涉及哌啶化合物，含有它们的组合物及其在治疗或预防与AT2受体功能相关的病症或疾病的方法中的用途，包括神经性疼痛，炎性疼痛，与神经元超敏反应相关的病症，神经传导速度受损，细胞增殖紊乱 ，与骨吸收和骨形成之间的不平衡相关的疾病以及与异常神经再生相关的疾病。

    Heterocyclic Compounds and Methods For Their Use
    2.
    发明申请
    Heterocyclic Compounds and Methods For Their Use 审中-公开
    杂环化合物及其使用方法

    公开(公告)号：US20150011565A1

    公开(公告)日：2015-01-08

    申请号：US14373355

    申请日：2013-01-25

    申请人： Spinifex Pharmaceuticals Pty Ltd

    发明人： Thomas David McCarthy ,  Alan Naylor

    IPC分类号： C07D295/185 ,  C07D231/12

    CPC分类号： C07D241/04 ,  C07D231/12 ,  C07D243/08 ,  C07D295/185 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06

    摘要： The present invention relates to heterocyclic compounds useful for antagonizing angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperazine and diazepine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

    摘要翻译： 本发明涉及可用于拮抗血管紧张素II型2型（AT2）受体的杂环化合物。 更具体地，本发明涉及哌嗪和二氮杂化合物，其含有它们的组合物及其在治疗或预防与AT2受体功能相关的病症或疾病的方法中的用途，包括神经性疼痛，炎性疼痛，与神经元超敏反应相关的病症，神经传导速度受损，细胞 增生障碍，与骨吸收和骨形成之间的不平衡相关的疾病以及与异常神经再生有关的疾病。

    Pyrimidine derivatives as selective inhibitors of COX-2
    9.
    发明授权
    Pyrimidine derivatives as selective inhibitors of COX-2 失效
    嘧啶衍生物作为COX-2的选择性抑制剂

    公开(公告)号：US06780870B2

    公开(公告)日：2004-08-24

    申请号：US10182788

    申请日：2002-07-31

    申请人： Malcolm Clive Carter ,  Alan Naylor ,  Jeremy John Payne ,  Neil Anthony Pegg

    发明人： Malcolm Clive Carter ,  Alan Naylor ,  Jeremy John Payne ,  Neil Anthony Pegg

    IPC分类号： C07D23942

    CPC分类号： C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

    摘要： The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl; R3 is C1-6alkyl or NH2; R4 is H or C1-6alkyl; A is a 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R5; R5 is halogen, C1-6alkyl, C1-6alkyl substituted by one ore more F, C1-6alkoxy, C1-6alkoxy substituted by one or more F, SO2NH2 or SO2C1-6alkyl; and n is 1 to 4.

    摘要翻译： 本发明提供式（I）化合物及其药学上可接受的衍生物，其中：R 1和R 2独立地选自H或C 1-6烷基; R 3是C 1-6烷基或NH 2; R 4是H或C 1-6烷基; A是5或6元芳基或被一个或多个R 5取代的5或6元芳基; R 5是卤素，C 1 -C 6烷基， 被一个或多个F，C 1-6烷氧基，被一个或多个F，SO 2 NH 2或SO 2 C 1-6烷基取代的C 1-6烷氧基取代的C 1-6烷基; andn是1到4。

    Chemical compounds
    10.
    发明授权
    Chemical compounds 失效

    公开(公告)号：US5023255A

    公开(公告)日：1991-06-11

    申请号：US493250

    申请日：1990-03-14

    申请人： Frank Ellis ,  Alan Naylor ,  Christopher J. Wallis ,  Ian Waterhouse

    发明人： Frank Ellis ,  Alan Naylor ,  Christopher J. Wallis ,  Ian Waterhouse

    IPC分类号： C12N9/99 ,  A61K31/53 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C281/02 ,  C07C281/06 ,  C07D233/64 ,  C07D253/06 ,  C07D281/02 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

    CPC分类号： C07D253/06

    摘要： Triazine derivatives of formula (I) ##STR1## or salts thereof, whereinR.sup.1 represents a halogen atom or a group selected from hydroxy; C.sub.1-8 alkyl C.sub.1-6 alkoxy; C.sub.1-3 alkoxy C.sub.1-3 alkoxy; phenoxy or phenyl C.sub.1-3 alkoxy, wherein the phenyl group is optionally substituted by a halogen atom or a group selected from C.sub.1-3 alkyl, C.sub.1-3 alkoxy, or hydroxy; fluoro C.sub.1-3 alkyl; cyano; --CO.sub.2 R.sup.3, wherein R.sup.3 represents a hydrogen atom or a C.sub.1-4 alkyl group; --CONR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 each independently represents a hydrogen atom or a C.sub.1-4 alkyl group, or, together with the nitrogen atom to which they are attached, form a saturated 5- to 7- membered ring, which ring optionally contains one or more atoms selected from an oxygen or a sulphur atom, or a group selected from --NH-- or --N(CH.sub.3)--; andR.sup.2 represents a hydrogen or halogen atom, or a group selected from hydroxy, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;are inhibitors of the enzyme 5-lipoxygenase.Processes for preparing the triazine derivatives of formula (I) and compositions containing them are also described.