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公开(公告)号：US07803760B2
公开(公告)日：2010-09-28
申请号：US12106882
申请日：2008-04-21
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
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2.发明授权公开(公告)号：US07507707B2
公开(公告)日：2009-03-24
申请号：US10498639
申请日：2001-12-14
申请人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
发明人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
IPC分类号： A61K31/00
CPC分类号： A61K31/437 , A61K31/00 , A61K31/138 , A61K31/277 , A61K31/352 , A61K31/4196 , A61K31/44 , A61K31/4535 , A61K31/502 , A61K31/519 , A61K31/522 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
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公开(公告)号：US20080293622A1
公开(公告)日：2008-11-27
申请号：US12106882
申请日：2008-04-21
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. Macnamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. Macnamee
IPC分类号： A61K38/24 , A61K31/4196 , A61P15/00
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
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公开(公告)号：US07078236B2
公开(公告)日：2006-07-18
申请号：US11169183
申请日：2005-06-28
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
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公开(公告)号：US06953774B2
公开(公告)日：2005-10-11
申请号：US10014812
申请日：2001-12-14
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K31/00 , A61K31/137 , A61K38/24
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase type 4.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是4型磷酸二酯酶抑制剂。
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公开(公告)号：US07364910B2
公开(公告)日：2008-04-29
申请号：US11456033
申请日：2006-07-06
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
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7.发明申请公开(公告)号：US20050148501A1
公开(公告)日：2005-07-07
申请号：US10498639
申请日：2001-12-14
申请人： Stephen Palmer , Mark Tepper , Sean Mckenna , Michael Macnamee , Aliza Eshkol
发明人： Stephen Palmer , Mark Tepper , Sean Mckenna , Michael Macnamee , Aliza Eshkol
IPC分类号： A61K45/00 , A61K31/00 , A61K31/138 , A61K31/192 , A61K31/277 , A61K31/44 , A61K31/444 , A61K31/502 , A61K31/519 , A61K38/22 , A61K38/24 , A61K45/06 , A61P15/08 , A61P43/00
CPC分类号： A61K31/437 , A61K31/00 , A61K31/138 , A61K31/277 , A61K31/352 , A61K31/4196 , A61K31/44 , A61K31/4535 , A61K31/502 , A61K31/519 , A61K31/522 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
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公开(公告)号：US20060293222A1
公开(公告)日：2006-12-28
申请号：US11456033
申请日：2006-07-06
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael MacNamee
IPC分类号： A61K38/24
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译： 本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。 另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。 优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。
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公开(公告)号：US20060003925A1
公开(公告)日：2006-01-05
申请号：US11169183
申请日：2005-06-28
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael MacNamee
IPC分类号： A61K38/24
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
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公开(公告)号：US20080014172A1
公开(公告)日：2008-01-17
申请号：US11596416
申请日：2005-05-31
申请人： Ann Clark , David Kagan , Stephen Palmer
发明人： Ann Clark , David Kagan , Stephen Palmer
CPC分类号： G01N33/6863 , A61K38/09 , A61K38/20 , A61K45/06 , C07K16/241 , G01N33/543 , G01N33/56966 , G01N33/6869 , G01N2333/495 , G01N2500/00 , G01N2800/364 , A61K2300/00
摘要： The present invention is directed to methods for ameliorating reproductive disorders. More specifically, the present invention describes methods and compositions for using IL-17 in the treatment of various infertility-related defects.
摘要翻译： 本发明涉及改善生殖障碍的方法。 更具体地，本发明描述了用于治疗各种不育症相关缺陷的用于使用IL-17的方法和组合物。
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