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    Process for isolation of hepatoprotective agent “oleanolic acid” from Lantana camera
    4.
    发明授权
    Process for isolation of hepatoprotective agent “oleanolic acid” from Lantana camera 失效
    从Lantana相机中分离肝保护剂“齐墩果酸”的方法

    公开(公告)号：US06884908B2

    公开(公告)日：2005-04-26

    申请号：US10815095

    申请日：2004-03-30

    申请人： Santosh Kumar Srivastava ,  Merajuddin Khan ,  Suman Preet Singh Khanuja

    发明人： Santosh Kumar Srivastava ,  Merajuddin Khan ,  Suman Preet Singh Khanuja

    IPC分类号： C11B1/04 ,  C11B1/10 ,  C11B3/00 ,  C11B7/00 ,  C07C61/12

    CPC分类号： C11B3/006 ,  C11B1/04 ,  C11B1/10 ,  C11B7/0025 ,  C11B7/0075

    摘要： Accordingly the present invention provides an improved and economical process for the isolation of oleanolic acid from the roots of Lantana camara, which comprises of drying, grinding and defattening of Lantana camara roots with light petroleum followed by over night extractions at room temperature (30-40° C.) three times with a single solvent selected from CH2Cl2, CHCl3, EtOAc, ether, acetone, MeOH, EtOH etc., removal of solvent under vacuum at 35-45° C., precipitation of crude extract and repeated partial crystallization of precipitate with a single solvent selected from CH2Cl2, CHCl3, EtOAc, ether, acetone, MeOH, EtOH, H2O and others resulting in the isolation of oleanolic acid with 1% yield.

    摘要翻译： 因此，本发明提供了一种用于从马齿苋根中分离齐墩果酸的改进和经济的方法，其包括用轻质石油干燥，研磨和降解马缨丹的根，然后在室温下过夜（30-40℃） ℃，使用选自CH 2 Cl 2，CHCl 3 3，EtOAc，乙醚，丙酮，MeOH，EtOH的单一溶剂三次 等等，在35-45℃下真空除去溶剂，沉淀粗提取物并用选自CH 2 Cl 2的单一溶剂重结晶沉淀物， CHCl 3 3，EtOAc，乙醚，丙酮，MeOH，EtOH，H 2 O 2等，其结果以1％产率分离齐墩果酸。