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    PROCESS FOR PREPARING BREVIFOLIOL
    5.
    发明申请
    PROCESS FOR PREPARING BREVIFOLIOL 有权
    制备BREVIFOLIOL的方法

    公开(公告)号：US20080039641A1

    公开(公告)日：2008-02-14

    申请号：US11548166

    申请日：2006-10-10

    申请人： Sunil Chattopadhyay ,  Sachin Srivastava ,  Arvind Negi ,  Ranganathan Tirupadiripuliyur ,  Ankur Garg ,  Suman Khanuja

    发明人： Sunil Chattopadhyay ,  Sachin Srivastava ,  Arvind Negi ,  Ranganathan Tirupadiripuliyur ,  Ankur Garg ,  Suman Khanuja

    IPC分类号： C07D305/00

    CPC分类号： C07C67/56 ,  C07C2603/30 ,  C07C69/78

    摘要： The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.

    摘要翻译： 本发明提供了一种通过首先用醇优选在20-40℃的温度下提取植物的干燥和粉碎的叶来生产属于紫杉属的植物的式I的抗癌紫杉烷类短纤维醇的方法 C.然后。 浓缩溶剂以获得醇提取物。 然后将所得醇提物用吸附剂吸附，然后将所得吸附材料在20-50℃的温度范围内干燥4-48小时。 然后将干燥的吸附材料用脂肪族溶剂和氯化溶剂的组合连续萃取并浓缩，得到残余物。 使用柱色谱法如硅胶，佛罗里达和硅酸对残余物进行粗分馏，然后用合适的吸附剂进行色谱以得到短纤维醇。

    Dynamic Morphology Based Atrial Automatic Threshold
    8.
    发明申请
    Dynamic Morphology Based Atrial Automatic Threshold 审中-公开
    基于动态形态的心房自动阈值

    公开(公告)号：US20130013019A1

    公开(公告)日：2013-01-10

    申请号：US13612077

    申请日：2012-09-12

    申请人： Derek D. Bohn ,  Ankur Garg ,  Eric K. Enrooth

    发明人： Derek D. Bohn ,  Ankur Garg ,  Eric K. Enrooth

    IPC分类号： A61N1/37

    CPC分类号： A61N1/371 ,  A61N1/3712

    摘要： Methods and systems for performing capture threshold tests are described. During an initialization procedure a capture detection interval and capture detection threshold are determined based on peak values of cardiac signals sensed following the supracapture threshold initialization pulses. Following initialization, a plurality of pacing pulses to the atrium are delivered and the peak values of the cardiac signals sensed following each of the plurality of pacing pulses are determined. The peak values are compared to the pacing artifact threshold and the capture detection threshold. A timing of each of the peak values is compared to the capture detection interval. For each pacing pulse, discrimination between a captured response, a noncaptured response, and a fusion response is based on the peak value and timing comparisons.

    摘要翻译： 描述用于执行捕获阈值测试的方法和系统。 在初始化过程期间，捕获检测间隔和捕获检测阈值是基于超标准阈值初始化脉冲之后感测的心脏信号的峰值来确定的。 在初始化之后，传送到心房的多个起搏脉冲，并且确定在多个起搏脉冲之后检测到的心脏信号的峰值。 将峰值与起搏伪像阈值和捕获检测阈值进行比较。 将每个峰值的定时与捕获检测间隔进行比较。 对于每个起搏脉冲，捕获的响应，非捕获响应和融合响应之间的区别基于峰值和时序比较。

    Atrial Capture Verification
    9.
    发明申请
    Atrial Capture Verification 有权
    心房拍摄验证

    公开(公告)号：US20090306737A1

    公开(公告)日：2009-12-10

    申请号：US12540902

    申请日：2009-08-13

    申请人： Geng Zhang ,  Ankur Garg ,  Douglas R. Daum

    发明人： Geng Zhang ,  Ankur Garg ,  Douglas R. Daum

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3712 ,  A61N1/3622 ,  A61N1/3714

    摘要： Methods and systems for classifying cardiac responses to pacing stimulation and/or preventing retrograde cardiac conduction are described. Following delivery of a pacing pulse to an atrium of the patient's heart during a cardiac cycle, the system senses in the atrium for a retrograde P-wave. The system classifies the atrial response to the pacing pulse based on detection of the retrograde P-wave. The system may also sense for an atrial evoked response and utilize the atrial evoked response in classifying the cardiac pacing response.

    摘要翻译： 描述了用于将心脏反应分类为起搏刺激和/或预防逆行心脏传导的方法和系统。 在心脏周期内将起搏脉搏递送到患者心脏的心房后，系统在心房感测逆行P波。 该系统基于逆行P波的检测将起搏脉冲的心房响应分类。 该系统还可以感知心房诱发反应并且利用心房诱发反应来分类心脏起搏反应。

    Process for preparing brevifoliol
    10.
    发明授权
    Process for preparing brevifoliol 有权
    短纤维酚的制备方法

    公开(公告)号：US07579491B2

    公开(公告)日：2009-08-25

    申请号：US11548166

    申请日：2006-10-10

    申请人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Arvind Singh Negi ,  Ranganathan Santha Kumar Tirupadiripuliyur ,  Ankur Garg ,  Suman Preet Singh Khanuja

    发明人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Arvind Singh Negi ,  Ranganathan Santha Kumar Tirupadiripuliyur ,  Ankur Garg ,  Suman Preet Singh Khanuja

    IPC分类号： C07D305/00 ,  A61K36/13

    CPC分类号： C07C67/56 ,  C07C2603/30 ,  C07C69/78

    摘要： The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.

    摘要翻译： 本发明提供了一种通过首先用醇优选在20-40℃的温度下提取植物的干燥和粉碎的叶来生产属于紫杉属的植物的式I的抗癌紫杉烷类短纤维醇的方法 C.然后。 浓缩溶剂以获得醇提取物。 然后将所得醇提物用吸附剂吸附，然后将所得吸附材料在20-50℃的温度范围内干燥4-48小时。 然后将干燥的吸附材料用脂肪族溶剂和氯化溶剂的组合连续萃取并浓缩，得到残余物。 使用柱色谱法如硅胶，佛罗里达和硅酸对残余物进行粗分馏，然后用合适的吸附剂进行色谱以得到短纤维醇。