公开(公告)号：US10435399B2

公开(公告)日：2019-10-08

申请号：US16049359

申请日：2018-07-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masahiro Ito ,  Hideyuki Sugiyama ,  Osamu Kubo ,  Fumiaki Kikuchi ,  Takeshi Yasui ,  Keiko Kakegawa ,  Zenichi Ikeda ,  Tohru Miyazaki ,  Yasuyoshi Arikawa ,  Tomohiro Okawa ,  Jinichi Yonemori ,  Akinori Toita ,  Takuto Kojima ,  Yasutomi Asano ,  Ayumu Sato ,  Hironobu Maezaki ,  Shinobu Sasaki ,  Hironori Kokubo ,  Misaki Homma ,  Minoru Sasaki ,  Yasuhiro Imaeda

IPC: C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  C07D487/04 ,  A61P25/28 ,  C07D471/04

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US08933069B2

公开(公告)日：2015-01-13

申请号：US14223329

申请日：2014-03-24

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Misaki Homma ,  Yuya Oguro

IPC: A61K31/00 ,  C07D495/04 ,  C07D498/20

CPC classification number: A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D495/04 ,  C07D498/20

Abstract: Provided is a compound useful for the prophylaxis or treatment of cancer.The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

Abstract translation: 提供一种可用于预防或治疗癌症的化合物。 本发明涉及由式（I）表示的化合物：其中式中的每个符号如本说明书中所定义，或其盐或其前药，其可用于预防或治疗癌症。

公开(公告)号：US11746109B2

公开(公告)日：2023-09-05

申请号：US16088096

申请日：2017-03-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kentaro Iwata ,  Masahiro Mizuno ,  Kazuhiro Maeda ,  Tsuneo Yasuma ,  Misaki Homma ,  Yuya Oguro ,  Naohiro Taya ,  Lei Zhu ,  John Daniel Bailey ,  Marianne Langston ,  Siddhesh Dinanath Patil ,  Shruti Gour ,  Lilly Roy

IPC: C07D471/08 ,  A61K9/48

CPC classification number: C07D471/08 ,  A61K9/485 ,  A61K9/4858 ,  C07B2200/13

Abstract: The present disclosure relates to crystalline forms of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one hemihydrate (Compound 1) and/or tautomers thereof, wherein Compound 1 has the structure: (I)·0.5H2O; processes for preparing crystalline forms of Compound 1 and/or tautomers thereof; pharmaceutical compositions comprising the crystalline forms; methods of inhibiting a cell division cycle 7 in a mammal comprising administering the crystalline forms; and methods of treating a cell division cycle 7 mediated cancer in a mammal comprising administering the crystalline forms or a pharmaceutical composition comprising the crystalline forms.

公开(公告)号：US09388195B2

公开(公告)日：2016-07-12

申请号：US14566157

申请日：2014-12-10

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Misaki Homma ,  Toru Miyazaki ,  Yuya Oguro ,  Osamu Kurasawa

IPC: C07D495/04 ,  C07D498/20

CPC classification number: A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D495/04 ,  C07D498/20

Abstract: Provided is a compound useful for the prophylaxis or treatment of cancer.The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

公开(公告)号：US08921354B2

公开(公告)日：2014-12-30

申请号：US14223259

申请日：2014-03-24

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Misaki Homma ,  Toru Miyazaki

IPC: A61K31/00 ,  C07D495/04 ,  C07D498/20

CPC classification number: A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D495/04 ,  C07D498/20

Abstract: Provided is a compound useful for the prophylaxis or treatment of cancer.The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

公开(公告)号：US12084436B2

公开(公告)日：2024-09-10

申请号：US17426971

申请日：2020-01-29

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Masahiro Ito ,  Takeshi Yamamoto ,  Keiko Kakegawa ,  Hideyuki Sugiyama ,  Tohru Miyazaki ,  Yasuyoshi Arikawa ,  Tomohiro Okawa ,  Jinichi Yonemori ,  Osamu Kubo ,  Akinori Toita ,  Takuto Kojima ,  Fumiaki Kikuchi ,  Minoru Sasaki ,  Misaki Homma ,  Yasuhiro Imaeda ,  Hironobu Maezaki ,  Shiinobu Sasaki ,  Ayumu Sato ,  Hirotaka Kamitani ,  Yasutomi Asano ,  Hironori Kokubo ,  Masato Yoshikawa

IPC: C07D413/10 ,  C07D271/06 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D413/10 ,  C07D271/06 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I):




wherein each symbol is as described in the description, or a salt thereof.

公开(公告)号：US09655900B2

公开(公告)日：2017-05-23

申请号：US15176893

申请日：2016-06-08

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Misaki Homma ,  Toru Miyazaki ,  Yuya Oguro ,  Osamu Kurasawa

IPC: A61K31/519 ,  C07D495/04 ,  C07D498/20 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55

CPC classification number: A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D495/04 ,  C07D498/20

Abstract: Provided is a compound useful for the prophylaxis or treatment of cancer.The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.