公开(公告)号：US12084436B2

公开(公告)日：2024-09-10

申请号：US17426971

申请日：2020-01-29

申请人： Takeda Pharmaceutical Company Limited

发明人： Masahiro Ito ,  Takeshi Yamamoto ,  Keiko Kakegawa ,  Hideyuki Sugiyama ,  Tohru Miyazaki ,  Yasuyoshi Arikawa ,  Tomohiro Okawa ,  Jinichi Yonemori ,  Osamu Kubo ,  Akinori Toita ,  Takuto Kojima ,  Fumiaki Kikuchi ,  Minoru Sasaki ,  Misaki Homma ,  Yasuhiro Imaeda ,  Hironobu Maezaki ,  Shiinobu Sasaki ,  Ayumu Sato ,  Hirotaka Kamitani ,  Yasutomi Asano ,  Hironori Kokubo ,  Masato Yoshikawa

IPC分类号： C07D413/10 ,  C07D271/06 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D413/10 ,  C07D271/06 ,  C07D413/14 ,  C07D417/14

摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I):




wherein each symbol is as described in the description, or a salt thereof.

公开(公告)号：US11584737B2

公开(公告)日：2023-02-21

申请号：US17042394

申请日：2019-03-28

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Koji Ono ,  Masahiro Ito ,  Toshio Tanaka ,  Moriteru Asano ,  Takaharu Hirayama ,  Jun Fujimoto ,  Nobuki Sakauchi ,  Yasuhiro Hirata ,  Akinori Toita ,  Nao Morishita ,  Hironori Kokubo ,  Yasuhiro Imaeda ,  Hironobu Maezaki ,  Douglas Robert Cary ,  Ryo Mizojiri ,  Nobuo Cho ,  Hiroshi Banno ,  Hidekazu Tokuhara ,  Yasuyoshi Arikawa

IPC分类号： C07D401/14 ,  C07D403/14 ,  A61P35/00 ,  C07D213/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D471/10 ,  C07D487/10 ,  C07D495/10

摘要： Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US10435399B2

公开(公告)日：2019-10-08

申请号：US16049359

申请日：2018-07-30

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Masahiro Ito ,  Hideyuki Sugiyama ,  Osamu Kubo ,  Fumiaki Kikuchi ,  Takeshi Yasui ,  Keiko Kakegawa ,  Zenichi Ikeda ,  Tohru Miyazaki ,  Yasuyoshi Arikawa ,  Tomohiro Okawa ,  Jinichi Yonemori ,  Akinori Toita ,  Takuto Kojima ,  Yasutomi Asano ,  Ayumu Sato ,  Hironobu Maezaki ,  Shinobu Sasaki ,  Hironori Kokubo ,  Misaki Homma ,  Minoru Sasaki ,  Yasuhiro Imaeda

IPC分类号： C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  C07D487/04 ,  A61P25/28 ,  C07D471/04

摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09221836B2

公开(公告)日：2015-12-29

申请号：US14665237

申请日：2015-03-23

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Takanobu Kuroita ,  Yasuhiro Imaeda ,  Kouichi Iwanaga ,  Naohiro Taya ,  Hidekazu Tokuhara

IPC分类号： A61K31/445 ,  C07D401/12 ,  C07D495/04 ,  C07D233/90 ,  C07D401/14 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D405/14

CPC分类号： C07D401/12 ,  C07D233/90 ,  C07D401/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04

摘要： Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.